不同侧张力性气胸对猪血流动力学的影响
R561.4; 目的 探讨不同侧张力性气胸对猪血流动力学的影响,为优化气胸现场一线救治流程提供数据支持.方法 12只巴马猪随机分为左侧张力性气胸组与右侧张力性气胸组,每组6只.通过脉搏指示连续心输出量监测(PICCO)技术在气胸及以1 mmHg为单位逐渐增大的胸膜腔压力下采集相关指标,包括血流动力学指标[全心射血分数(GEF)、心输出量(CO)、全心舒张末容量(GEDV)、胸腔内血容量(ITBV)、每搏量(SV)、平均动脉压(MAP)]、基础生命体征指标[心率(HR)、舒张压(DBP)、收缩压(SBP)]及动脉血气指标[氧分压(PO2)、二氧化碳分压(PCO2)],随后使用X线片进行纵隔定位....
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| Published in | 解放军医学杂志 Vol. 49; no. 8; pp. 897 - 904 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
解放军医学院,北京 100853%锦州医科大学解放军总医院第三医学中心研究生培养基地,北京 100039%首都医科大学基础医学院,北京 100069%解放军总医院第三医学中心超声科,北京 100039%解放军总医院第三医学中心急诊科,北京 100039
28.08.2024
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0577-7402 |
| DOI | 10.11855/j.issn.0577-7402.0229.2024.0530 |
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| Abstract | R561.4; 目的 探讨不同侧张力性气胸对猪血流动力学的影响,为优化气胸现场一线救治流程提供数据支持.方法 12只巴马猪随机分为左侧张力性气胸组与右侧张力性气胸组,每组6只.通过脉搏指示连续心输出量监测(PICCO)技术在气胸及以1 mmHg为单位逐渐增大的胸膜腔压力下采集相关指标,包括血流动力学指标[全心射血分数(GEF)、心输出量(CO)、全心舒张末容量(GEDV)、胸腔内血容量(ITBV)、每搏量(SV)、平均动脉压(MAP)]、基础生命体征指标[心率(HR)、舒张压(DBP)、收缩压(SBP)]及动脉血气指标[氧分压(PO2)、二氧化碳分压(PCO2)],随后使用X线片进行纵隔定位.通过两组之间互相比较及组内前后比较的方式探究其差异性.结果 通过比较血流动力学变化及X线片检查结果,12只巴马猪张力性气胸模型均构建成功.血流动力学分析结果显示,左侧张力性气胸在胸膜腔压力为8 mmHg时,与同侧气胸时相比,SBP、DBP、MAP、CO、GEF、SV、GEDV及ITBV明显下降(P<0.05).右侧张力性气胸在胸膜腔压力为3 mmHg时,与同侧气胸时相比,SBP、DBP、MAP、SV、GEDV及ITBV明显下降(P<0.05).血气分析结果显示,左侧张力性气胸(胸膜腔压力为8 mmHg)及右侧张力性气胸(胸膜腔压力为3 mmHg)时,与各自同侧气胸时相比,PO2明显降低(P<0.05),PCO2明显升高(P<0.05).结论 不同侧张力性气胸存在差异性,在较小的胸膜腔压力下右侧张力性气胸较左侧更易导致严重后果.进行张力性气胸相关实验时可根据实际情况构建不同侧张力性气胸模型. |
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| AbstractList | R561.4; 目的 探讨不同侧张力性气胸对猪血流动力学的影响,为优化气胸现场一线救治流程提供数据支持.方法 12只巴马猪随机分为左侧张力性气胸组与右侧张力性气胸组,每组6只.通过脉搏指示连续心输出量监测(PICCO)技术在气胸及以1 mmHg为单位逐渐增大的胸膜腔压力下采集相关指标,包括血流动力学指标[全心射血分数(GEF)、心输出量(CO)、全心舒张末容量(GEDV)、胸腔内血容量(ITBV)、每搏量(SV)、平均动脉压(MAP)]、基础生命体征指标[心率(HR)、舒张压(DBP)、收缩压(SBP)]及动脉血气指标[氧分压(PO2)、二氧化碳分压(PCO2)],随后使用X线片进行纵隔定位.通过两组之间互相比较及组内前后比较的方式探究其差异性.结果 通过比较血流动力学变化及X线片检查结果,12只巴马猪张力性气胸模型均构建成功.血流动力学分析结果显示,左侧张力性气胸在胸膜腔压力为8 mmHg时,与同侧气胸时相比,SBP、DBP、MAP、CO、GEF、SV、GEDV及ITBV明显下降(P<0.05).右侧张力性气胸在胸膜腔压力为3 mmHg时,与同侧气胸时相比,SBP、DBP、MAP、SV、GEDV及ITBV明显下降(P<0.05).血气分析结果显示,左侧张力性气胸(胸膜腔压力为8 mmHg)及右侧张力性气胸(胸膜腔压力为3 mmHg)时,与各自同侧气胸时相比,PO2明显降低(P<0.05),PCO2明显升高(P<0.05).结论 不同侧张力性气胸存在差异性,在较小的胸膜腔压力下右侧张力性气胸较左侧更易导致严重后果.进行张力性气胸相关实验时可根据实际情况构建不同侧张力性气胸模型. |
| Abstract_FL | Objective To explore the effects of different side tension pneumothorax on hemodynamics in pigs,providing data support for the optimization of on-site first-aid procedures for pneumothorax.Methods Twelve Bama pigs were randomly divided into left-sided tension pneumothorax group and right-sided tension pneumothorax group(6 in each group).During the occurrence of pneumothorax and as the pleural pressure gradually increases by 1 mmHg increments,the key indicators were collected using pulse indicator continuous cardiac output(PICCO)technology:hemodynamic indicators[global ejection fraction(GEF),cardiac output(CO),global end-diastolic volume(GEDV),intrathoracic blood volume(ITBV),stroke volume(SV),mean arterial pressure(MAP)],basic vital signs[heart rate(HR),diastolic blood pressure(DBP),systolic blood pressure(SBP)],and arterial blood gas parameters[partial pressure of oxygen(PO2),partial pressure of carbon dioxide(PCO2)].Mediastinal localization was subsequently performed using radiographs.Differences were investigated through comparison between the two groups and within each group before and after the procedure.Results By comparing the hemodynamic changes and X-ray examination results,twelve Bama pigs tension pneumothorax models were successfully constructed.Hemodynamic analysis showed that in left-sided tension pneumothorax model when the pleural pressure reached 8 mmHg,SBP,DBP,MAP,CO,GEF,SV,GEDV and ITBV were significantly lower than those during the occurrence of ipsilateral pneumothorax(P<0.05).In right-sided tension pneumothorax model,when the pleural pressure reached about 3 mmHg,SBP,DBP,MAP,SV,GEDV,and ITBV were significantly lower than those during the occurrence of ipsilateral pneumothorax(P<0.05).Blood gas analysis showed that at 8 mmHg for left-sided and 3 mmHg for right-sided tension pneumothorax,compared with the occurrence of their respective ipsilateral pneumothorax,PO2 was significantly lower(P<0.05)and PCO2 was significantly higher(P<0.05).Conclusions There are different effects on hemodynamics in different side tension pneumothorax.Compared with left tension pneumothorax,right tension pneumothorax can lead to serious consequences under a smaller pleural pressure.Different side tension pneumothorax models can be constructed according to the actual situation when performing pneumothorax related experiments. |
| Author | 刘鹏飞 陈思羽 黄河山 豆梦杰 陈威 吕发勤 |
| AuthorAffiliation | 解放军医学院,北京 100853%锦州医科大学解放军总医院第三医学中心研究生培养基地,北京 100039%首都医科大学基础医学院,北京 100069%解放军总医院第三医学中心超声科,北京 100039%解放军总医院第三医学中心急诊科,北京 100039 |
| AuthorAffiliation_xml | – name: 解放军医学院,北京 100853%锦州医科大学解放军总医院第三医学中心研究生培养基地,北京 100039%首都医科大学基础医学院,北京 100069%解放军总医院第三医学中心超声科,北京 100039%解放军总医院第三医学中心急诊科,北京 100039 |
| Author_FL | Liu Peng-Fei Lyu Fa-Qin Huang He-Shan Dou Meng-Jie Chen Si-Yu Chen Wei |
| Author_FL_xml | – sequence: 1 fullname: Huang He-Shan – sequence: 2 fullname: Liu Peng-Fei – sequence: 3 fullname: Dou Meng-Jie – sequence: 4 fullname: Chen Si-Yu – sequence: 5 fullname: Lyu Fa-Qin – sequence: 6 fullname: Chen Wei |
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| DocumentTitle_FL | Effects of different side tension pneumothorax on hemodynamic in pigs |
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| Keywords | 自主呼吸 动物模型 animal model tension pneumothorax autonomous respiration hemodynamics 张力性气胸 血流动力学 |
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| Snippet | R561.4; 目的 探讨不同侧张力性气胸对猪血流动力学的影响,为优化气胸现场一线救治流程提供数据支持.方法 12只巴马猪随机分为左侧张力性气胸组与右侧张力性气胸组,每组6只.通过脉搏指示连续心输出量监测(PICCO)技术在气胸及以1... |
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| Title | 不同侧张力性气胸对猪血流动力学的影响 |
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