两性离子多肽改善GLP-1生物活性的粗粒化分子模拟

O617; 以胰高血糖素样肽-1(GLP-1)与多肽的混合体系作为研究对象,利用粗粒化分子模拟对其作用模式进行研究.结果显示,3种混合体系都有利于GLP-1形成螺旋结构.其中,两性离子五肽VPKEG具有较强亲水性,在GLP-1周围形成疏松的保护层;而两性离子五肽VPREG与GLP-1形成较多静电作用;对照组五肽VPGAG具有较强疏水性,形成致密聚集体,未能给GLP-1提供足够保护.赖氨酸、谷氨酸组合让两性离子五肽VPKEG具备了恰当的亲疏水性和静电作用,既能维持GLP-1构象,也可避免被免疫蛋白识别,赋予其"隐身"特性....

Full description

Saved in:
Bibliographic Details
Published in功能高分子学报 Vol. 34; no. 3; pp. 260 - 268
Main Authors 滕家曼, 刘玉婷, 朱国梁, 谌庄琳, 陈彦涛
Format Journal Article
LanguageChinese
Published 深圳大学化学与环境工程学院,深圳市环境化学与生态修复重点实验室,广东 深圳 518071 2021
Subjects
分子模拟
两性离子多肽
胰高血糖素样肽-1
Online AccessGet full text
ISSN1008-9357
DOI10.14133/j.cnki.1008-9357.20210118002

Cover

Abstract O617; 以胰高血糖素样肽-1(GLP-1)与多肽的混合体系作为研究对象,利用粗粒化分子模拟对其作用模式进行研究.结果显示,3种混合体系都有利于GLP-1形成螺旋结构.其中,两性离子五肽VPKEG具有较强亲水性,在GLP-1周围形成疏松的保护层;而两性离子五肽VPREG与GLP-1形成较多静电作用;对照组五肽VPGAG具有较强疏水性,形成致密聚集体,未能给GLP-1提供足够保护.赖氨酸、谷氨酸组合让两性离子五肽VPKEG具备了恰当的亲疏水性和静电作用,既能维持GLP-1构象,也可避免被免疫蛋白识别,赋予其"隐身"特性.
AbstractList O617; 以胰高血糖素样肽-1(GLP-1)与多肽的混合体系作为研究对象,利用粗粒化分子模拟对其作用模式进行研究.结果显示,3种混合体系都有利于GLP-1形成螺旋结构.其中,两性离子五肽VPKEG具有较强亲水性,在GLP-1周围形成疏松的保护层;而两性离子五肽VPREG与GLP-1形成较多静电作用;对照组五肽VPGAG具有较强疏水性,形成致密聚集体,未能给GLP-1提供足够保护.赖氨酸、谷氨酸组合让两性离子五肽VPKEG具备了恰当的亲疏水性和静电作用,既能维持GLP-1构象,也可避免被免疫蛋白识别,赋予其"隐身"特性.
Author 滕家曼
谌庄琳
朱国梁
刘玉婷
陈彦涛
AuthorAffiliation 深圳大学化学与环境工程学院,深圳市环境化学与生态修复重点实验室,广东 深圳 518071
AuthorAffiliation_xml – name: 深圳大学化学与环境工程学院,深圳市环境化学与生态修复重点实验室,广东 深圳 518071
Author_FL LIU Yuting
TENG Jiaman
SHEN Zhuanglin
ZHU Guoliang
CHEN Yantao
Author_FL_xml – sequence: 1
  fullname: TENG Jiaman
– sequence: 2
  fullname: LIU Yuting
– sequence: 3
  fullname: ZHU Guoliang
– sequence: 4
  fullname: SHEN Zhuanglin
– sequence: 5
  fullname: CHEN Yantao
Author_xml – sequence: 1
  fullname: 滕家曼
– sequence: 2
  fullname: 刘玉婷
– sequence: 3
  fullname: 朱国梁
– sequence: 4
  fullname: 谌庄琳
– sequence: 5
  fullname: 陈彦涛
BookMark eNo9TztLw1AYvUMFa-3PEFwSv_vIfYylaBUCOuhcbpKb0Cq3YBDFSaSIooNIqdClCMXH4FIclOK_MYk_w_jA6cA5h_NYQBXbswahJQwuZpjSla4b2t2OiwGko6gnXAIEA8YSgFRQ9Z-fR_U07QRQSsAkF1XU-Hid5CcPxf0se77OJqPP0_d88JYN-y1_y8HFYFxcPOUvs2_LqF9Mb4vpTXY1zM7PSnv-eJdfjhfRXKz3UlP_wxraWVvdbq47_mZro9nwnRQD5Q6OGI2wiDRXShAWEMIJFySIhSnXEE9RGYeGh0QTHIgwoEZQraSnJTNAFaM1tPybe6htrG3S7vYO9m3Z2E5sEh8fBT-fKQCnX4aMZBo
ClassificationCodes O617
ContentType Journal Article
Copyright Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 2B.
4A8
92I
93N
PSX
TCJ
DOI 10.14133/j.cnki.1008-9357.20210118002
DatabaseName Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
DocumentTitle_FL Coarse-Grained Molecular Simulation of Zwitterionic Polypeptides on Improving the Bioactivity of Glucagon-Like Peptide-1(GLP-1)
EndPage 268
ExternalDocumentID gngfzxb202103006
GrantInformation_xml – fundername: (广东省自然科学基金); (深圳市科技计划项目)
  funderid: (广东省自然科学基金); (深圳市科技计划项目)
GroupedDBID -02
2B.
4A8
5XA
5XC
92E
92I
93N
ABDBF
ABJNI
ACGFS
ACUHS
ALMA_UNASSIGNED_HOLDINGS
CCEZO
CDRFL
CW9
P2P
PSX
TCJ
TGP
U1G
U5L
ID FETCH-LOGICAL-s1036-1d43d17da699724b2262672bf7e01125938fce6c2a21b7cb3e73a985a84e03943
ISSN 1008-9357
IngestDate Thu May 29 04:30:55 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords 分子模拟
两性离子多肽
胰高血糖素样肽-1
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-s1036-1d43d17da699724b2262672bf7e01125938fce6c2a21b7cb3e73a985a84e03943
PageCount 9
ParticipantIDs wanfang_journals_gngfzxb202103006
PublicationCentury 2000
PublicationDate 2021
PublicationDateYYYYMMDD 2021-01-01
PublicationDate_xml – year: 2021
  text: 2021
PublicationDecade 2020
PublicationTitle 功能高分子学报
PublicationTitle_FL Journal of Functional Polymers
PublicationYear 2021
Publisher 深圳大学化学与环境工程学院,深圳市环境化学与生态修复重点实验室,广东 深圳 518071
Publisher_xml – name: 深圳大学化学与环境工程学院,深圳市环境化学与生态修复重点实验室,广东 深圳 518071
SSID ssib001104867
ssj0037587
ssib008679450
ssib051370211
ssib002258405
Score 2.250645
Snippet O617; 以胰高血糖素样肽-1(GLP-1)与多肽的混合体系作为研究对象,利用粗粒化分子模拟对其作用模式进行研究.结果显示,3种混合体系都有利于GLP-1形成螺旋结构.其中,两性离子...
SourceID wanfang
SourceType Aggregation Database
StartPage 260
Title 两性离子多肽改善GLP-1生物活性的粗粒化分子模拟
URI https://d.wanfangdata.com.cn/periodical/gngfzxb202103006
Volume 34
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVEBS
  databaseName: EBSCOhost Academic Search Ultimate
  issn: 1008-9357
  databaseCode: ABDBF
  dateStart: 20170401
  customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn
  isFulltext: true
  dateEnd: 99991231
  titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn
  omitProxy: true
  ssIdentifier: ssj0037587
  providerName: EBSCOhost
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LaxRBEB7CBtSL-MQ3EexT2DjT0zPdfezezBpExEMCwUuY18YgrGASkJxEgih6EAkRcglC8HHwEjwowX_j7vozrKqZ2R3MEtTLUvR8_VV1VdOv7Yfj3Oi4SsdKdZqxkLIpMuE1odNLm1mSQVsYatyqi7st7oZzC-L2YrA40bhf27W0vpbMpBtjz5X8T1QhDeKKp2T_IbJDUkgAGeILvxBh-P2rGLNIMKuYESwKccuCkSySzITMWhYFzMwy7ZIgmDYsUkxxZmcRrCGjxk8aMopbd-41PcwKybqNgtLMaARaQWQ1emBSAgXLmZaVwJFMtZAPBVAV1kwImQEzPeKxoKI-JCa8Ib2QyycDQTvA1DgqEqCISGWYCaoaQ8ZCpoAgEbME0ZbZ1ghCdMgLJYywkIjVzMo6i24x65FvbOktw5nyRhDFrItlBYitnAGmWb--hMJHiydkmqxIgd0vg4IOHZan5r4yhYILdhbWmjZ94ugj1AyBDijcCn06yqWZ1gjjrfF6LVWDsZxHGFDWDKoHyqNPbXRzURBFMVOSBEnVTJdx0BGF05QOgxTA88J5GkkKLbo1fdjc6cBTbvF2Ttlx4jYa7ReXjVc9a7lMvVJfeCm6yeINiXLExYuHlQ515jC-8qk3T7sPV2aGGmYwhHR1octHo5jh3tLl7nJn40lCIJ9u45_kuFbXcCaNnbXt0WTBo-sma4NZGIzXej-8ilKM_vMPPF8C53ADmQ8zbXq6qbLrmMMqq28eZTMdD-x24u5ybSQ7f8o5WU5Bp0zRnpx2JjYenHGOt6qXH8865ue3vf7Tj4MPB70vb3p7O7-e_ehvfe9tb1I7MdjaHbz83P96gJCdzcH-u8H-297r7d6L5wDvf3rff7V7zlloR_OtuWb51Epz1cMryb1M-JknszjEg_QigUkZDyVPOjIHq3mgfdVJ8zDlMfcSmSZ-Lv1YqyBWInd9LfzzTqP7qJtfcKbcPHeTRLohTzwR5x3thipLuS9llupUy4vO9bL4S2VTurr0Z8wu_QXmsnMC5WI59IrTWHu8nl-FCcJacq2M9G-Wj8Fk
linkProvider EBSCOhost
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E4%B8%A4%E6%80%A7%E7%A6%BB%E5%AD%90%E5%A4%9A%E8%82%BD%E6%94%B9%E5%96%84GLP-1%E7%94%9F%E7%89%A9%E6%B4%BB%E6%80%A7%E7%9A%84%E7%B2%97%E7%B2%92%E5%8C%96%E5%88%86%E5%AD%90%E6%A8%A1%E6%8B%9F&rft.jtitle=%E5%8A%9F%E8%83%BD%E9%AB%98%E5%88%86%E5%AD%90%E5%AD%A6%E6%8A%A5&rft.au=%E6%BB%95%E5%AE%B6%E6%9B%BC&rft.au=%E5%88%98%E7%8E%89%E5%A9%B7&rft.au=%E6%9C%B1%E5%9B%BD%E6%A2%81&rft.au=%E8%B0%8C%E5%BA%84%E7%90%B3&rft.date=2021&rft.pub=%E6%B7%B1%E5%9C%B3%E5%A4%A7%E5%AD%A6%E5%8C%96%E5%AD%A6%E4%B8%8E%E7%8E%AF%E5%A2%83%E5%B7%A5%E7%A8%8B%E5%AD%A6%E9%99%A2%2C%E6%B7%B1%E5%9C%B3%E5%B8%82%E7%8E%AF%E5%A2%83%E5%8C%96%E5%AD%A6%E4%B8%8E%E7%94%9F%E6%80%81%E4%BF%AE%E5%A4%8D%E9%87%8D%E7%82%B9%E5%AE%9E%E9%AA%8C%E5%AE%A4%2C%E5%B9%BF%E4%B8%9C+%E6%B7%B1%E5%9C%B3+518071&rft.issn=1008-9357&rft.volume=34&rft.issue=3&rft.spage=260&rft.epage=268&rft_id=info:doi/10.14133%2Fj.cnki.1008-9357.20210118002&rft.externalDocID=gngfzxb202103006
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fgngfzxb%2Fgngfzxb.jpg