帕金森病发病机制研究进展
R742.5; 帕金森病是中老年人常见的神经系统慢性炎性变性疾病,以黑质中多巴胺能神经元减少和路易小体形成为主要病理基础,其常见临床表现有静止性震颤、运动迟缓、肌张力增强和姿势步态异常等.该病发病机制十分复杂,可能与年龄、环境、遗传、氧化应激及线粒体功能障碍等多种因素有关.本文综述了导致多巴胺能神经元变性的α-突触核蛋白、氧化应激、线粒体功能障碍,以及富含亮氨酸的重复激酶2(LRRK2)基因突变等因素在帕金森病发病过程中作用机制的相关研究进展,以期为帕金森病的基础和临床研究提供参考....
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| Published in | 解放军医学杂志 Vol. 48; no. 8; pp. 983 - 992 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
山西中医药大学基础医学院/神经生物学研究中心,山西晋中 030619%山西大同大学脑科学研究所,山西大同037009%复旦大学华山医院神经病学研究所,上海 200025
2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0577-7402 |
| DOI | 10.11855/j.issn.0577-7402.0303.2023.0224 |
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| Abstract | R742.5; 帕金森病是中老年人常见的神经系统慢性炎性变性疾病,以黑质中多巴胺能神经元减少和路易小体形成为主要病理基础,其常见临床表现有静止性震颤、运动迟缓、肌张力增强和姿势步态异常等.该病发病机制十分复杂,可能与年龄、环境、遗传、氧化应激及线粒体功能障碍等多种因素有关.本文综述了导致多巴胺能神经元变性的α-突触核蛋白、氧化应激、线粒体功能障碍,以及富含亮氨酸的重复激酶2(LRRK2)基因突变等因素在帕金森病发病过程中作用机制的相关研究进展,以期为帕金森病的基础和临床研究提供参考. |
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| AbstractList | R742.5; 帕金森病是中老年人常见的神经系统慢性炎性变性疾病,以黑质中多巴胺能神经元减少和路易小体形成为主要病理基础,其常见临床表现有静止性震颤、运动迟缓、肌张力增强和姿势步态异常等.该病发病机制十分复杂,可能与年龄、环境、遗传、氧化应激及线粒体功能障碍等多种因素有关.本文综述了导致多巴胺能神经元变性的α-突触核蛋白、氧化应激、线粒体功能障碍,以及富含亮氨酸的重复激酶2(LRRK2)基因突变等因素在帕金森病发病过程中作用机制的相关研究进展,以期为帕金森病的基础和临床研究提供参考. |
| Author | 马存根 贾璐 肖琪 徐磊 樊慧杰 李艳荣 肖保国 柴智 孙芮芮 尉杰忠 |
| AuthorAffiliation | 山西中医药大学基础医学院/神经生物学研究中心,山西晋中 030619%山西大同大学脑科学研究所,山西大同037009%复旦大学华山医院神经病学研究所,上海 200025 |
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| Author_FL | Xiao Qi Xiao Bao-Guo Ma Cun-Gen Fan Hui-Jie Xu Lei Sun Rui-Rui Chai Zhi Li Yan-Rong Jia Lu Wei Jie-Zhong |
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| Keywords | Parkinson's disease α-突触核蛋白 氧化应激 帕金森病 线粒体功能障碍 mitochondrial dysfunction LRRK2 gene mutation α-synuclein oxidative stress LRRK2基因突变 |
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