肺黏膜相关淋巴组织淋巴瘤临床特征及预后分析
R733.4; 目的:探讨肺黏膜相关淋巴组织(mucosa-associated lymphoid tissue,MALT)淋巴瘤的临床特征及预后.方法:回顾性分析2013年1月至2020年6月复旦大学附属中山医院血液科收治的77例初发肺M A L T淋巴瘤患者的临床资料.结果:77例肺MALT淋巴瘤患者,男性32例(41.6％),女性45例(58.4％),中位发病年龄为59(24～85)岁.肺占位患者32例(41.6％),症状起病患者45例(58.4％),主要表现为肺部非特异性症状.AnnArbor分期为Ⅰ期14例(18.2％)、Ⅱ期3例(3.9％)、Ⅲ期1例(1.3％)、Ⅳ期59例(76....
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| Published in | 中国临床医学 Vol. 28; no. 5; pp. 765 - 770 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
复旦大学附属中山医院血液科,上海 200032
01.10.2021
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-6358 |
| DOI | 10.12025/j.issn.1008-6358.2021.20210713 |
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| Abstract | R733.4; 目的:探讨肺黏膜相关淋巴组织(mucosa-associated lymphoid tissue,MALT)淋巴瘤的临床特征及预后.方法:回顾性分析2013年1月至2020年6月复旦大学附属中山医院血液科收治的77例初发肺M A L T淋巴瘤患者的临床资料.结果:77例肺MALT淋巴瘤患者,男性32例(41.6％),女性45例(58.4％),中位发病年龄为59(24～85)岁.肺占位患者32例(41.6％),症状起病患者45例(58.4％),主要表现为肺部非特异性症状.AnnArbor分期为Ⅰ期14例(18.2％)、Ⅱ期3例(3.9％)、Ⅲ期1例(1.3％)、Ⅳ期59例(76.6％).15例无治疗指征而观察随访,19例手术治疗,3例接受抗炎治疗,43例接受化疗治疗(化疗方案主要包括RC、R-CHOP、R2、BR等),2例患者拒绝治疗.一线治疗后最佳疗效,25例(32.5％)完全缓解,31例(40.2％)部分缓解,16例(20.8％)疾病稳定,2例(2.6％)病情进展,总体反应率72.7％.结束治疗后继续随访过程中,14例患者复发进展.随访截止时间为2020年11月20日,中位随访时间为35.3(5.5～96.0)个月,中位OS及PFS均未达到,5年OS率和PFS率分别为95.1％ 和73.2％.AnnArbor分期Ⅰ/Ⅱ期和Ⅲ/Ⅳ期患者的OS和PFS差异无统计学意义(P=0.455、0.834).接受局部治疗(主要是手术)与接受全身治疗(化疗)的患者相比,接受化疗组患者远期PFS更好(P=0.004).对于Ⅰ/Ⅱ期患者单独进行了不同治疗方案的PFS分析,趋势同整体人群相当.53例患者可计算POD24,7例患者POD24阳性,POD24对预后差异有统计学意义(P=0.046).结论:肺MALT淋巴瘤总体预后较好,不同疾病分期OS、PFS差异无统计学意义.接受全身化疗可能为患者带来更长的获益,而单纯手术治疗可能与较差的PFS相关.POD24阳性与肺MALT淋巴瘤不良预后相关. |
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| AbstractList | R733.4; 目的:探讨肺黏膜相关淋巴组织(mucosa-associated lymphoid tissue,MALT)淋巴瘤的临床特征及预后.方法:回顾性分析2013年1月至2020年6月复旦大学附属中山医院血液科收治的77例初发肺M A L T淋巴瘤患者的临床资料.结果:77例肺MALT淋巴瘤患者,男性32例(41.6％),女性45例(58.4％),中位发病年龄为59(24～85)岁.肺占位患者32例(41.6％),症状起病患者45例(58.4％),主要表现为肺部非特异性症状.AnnArbor分期为Ⅰ期14例(18.2％)、Ⅱ期3例(3.9％)、Ⅲ期1例(1.3％)、Ⅳ期59例(76.6％).15例无治疗指征而观察随访,19例手术治疗,3例接受抗炎治疗,43例接受化疗治疗(化疗方案主要包括RC、R-CHOP、R2、BR等),2例患者拒绝治疗.一线治疗后最佳疗效,25例(32.5％)完全缓解,31例(40.2％)部分缓解,16例(20.8％)疾病稳定,2例(2.6％)病情进展,总体反应率72.7％.结束治疗后继续随访过程中,14例患者复发进展.随访截止时间为2020年11月20日,中位随访时间为35.3(5.5～96.0)个月,中位OS及PFS均未达到,5年OS率和PFS率分别为95.1％ 和73.2％.AnnArbor分期Ⅰ/Ⅱ期和Ⅲ/Ⅳ期患者的OS和PFS差异无统计学意义(P=0.455、0.834).接受局部治疗(主要是手术)与接受全身治疗(化疗)的患者相比,接受化疗组患者远期PFS更好(P=0.004).对于Ⅰ/Ⅱ期患者单独进行了不同治疗方案的PFS分析,趋势同整体人群相当.53例患者可计算POD24,7例患者POD24阳性,POD24对预后差异有统计学意义(P=0.046).结论:肺MALT淋巴瘤总体预后较好,不同疾病分期OS、PFS差异无统计学意义.接受全身化疗可能为患者带来更长的获益,而单纯手术治疗可能与较差的PFS相关.POD24阳性与肺MALT淋巴瘤不良预后相关. |
| Author | 施淼颉 魏征 袁玲 王志梅 承璐雅 柯杨 刘澎 庄静丽 王伟光 季丽莉 程志祥 |
| AuthorAffiliation | 复旦大学附属中山医院血液科,上海 200032 |
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| Author_FL | WEI Zheng LIU Peng SHI Miao-jie JI Li-li CHENG Zhi-xiang KE Yang YUAN Ling WANG Zhi-mei ZHUANG Jing-li WANG Wei-guang CHENG Lu-ya |
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| Author_xml | – sequence: 1 fullname: 施淼颉 – sequence: 2 fullname: 魏征 – sequence: 3 fullname: 庄静丽 – sequence: 4 fullname: 王伟光 – sequence: 5 fullname: 王志梅 – sequence: 6 fullname: 柯杨 – sequence: 7 fullname: 程志祥 – sequence: 8 fullname: 袁玲 – sequence: 9 fullname: 季丽莉 – sequence: 10 fullname: 承璐雅 – sequence: 11 fullname: 刘澎 |
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| Keywords | 肺黏膜相关淋巴组织淋巴瘤;临床特征;手术;化疗;POD24 |
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| Title | 肺黏膜相关淋巴组织淋巴瘤临床特征及预后分析 |
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