血浆Quaking和环氧合酶-2水平预测冠心病患者行经皮冠状动脉介入术后支架内再狭窄

目的:经皮冠状动脉介入术(percutaneous coronary intervention,PCI)是治疗冠心病的重要手段之一,支架植入术后发生的支架内再狭窄(in-stent restenosis,ISR)是影响冠心病患者PCI术后远期疗效及预后的重要因素.本研究旨在探讨血浆Quaking(QKI)、环氧合酶-2(cyclooxygenase-2,COX-2)水平与冠心病患者PCI术后ISR的相关性.方法:连续选取2019年9月至2020年9月在中南大学湘雅医院心血管内科行冠状动脉造影并行支架植入术的冠心病患者218例,选取同期在体检中心体检的与冠心病患者基线资料相匹配的35例个体作为对...

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Published in中南大学学报（医学版） Vol. 47; no. 6; pp. 739 - 747
Main Authors 王萍, 匡圆圆, 刘昱博, 张银妆, 高浩东, 马琦琳
Format Journal Article
LanguageChinese
Published 中南大学湘雅医院心血管内科,国家老年疾病临床医学研究中心(湘雅医院),长沙410008%长沙市第一医院心内科,长沙410005 2022
Subjects
经皮冠状动脉介入治疗
冠心病
Quaking
支架内再狭窄
主要不良心血管事件
环氧合酶-2
Online AccessGet full text
ISSN1672-7347
DOI10.11817/j.issn.1672-7347.2022.210716

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Abstract 目的:经皮冠状动脉介入术(percutaneous coronary intervention,PCI)是治疗冠心病的重要手段之一,支架植入术后发生的支架内再狭窄(in-stent restenosis,ISR)是影响冠心病患者PCI术后远期疗效及预后的重要因素.本研究旨在探讨血浆Quaking(QKI)、环氧合酶-2(cyclooxygenase-2,COX-2)水平与冠心病患者PCI术后ISR的相关性.方法:连续选取2019年9月至2020年9月在中南大学湘雅医院心血管内科行冠状动脉造影并行支架植入术的冠心病患者218例,选取同期在体检中心体检的与冠心病患者基线资料相匹配的35例个体作为对照组.入院后收集两组患者的临床资料,采用酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)测定血浆QKI、COX-2水平.术后12个月复查冠心病患者的冠状动脉造影,根据是否发生ISR将218例冠心病患者分为无再狭窄组(NISR组,n=160)与再狭窄组(ISR组,n=58).比较NISR组与ISR组的一般资料及冠状动脉临床指标,采用多因素logistic回归分析ISR的影响因素.记录1年内主要不良心血管事件(major adverse cardiovascular events,MACE)发生情况,并据此将58例PCI术后ISR患者分为未发生MACE组(34例)与发生MACE组(24例),比较两组的血浆QKI、COX-2水平,采用受试者操作特征(receiver operating characteristic,ROC)曲线探究血浆QKI、COX-2水平对PCI术后ISR及MACE的诊断价值.结果:与对照组相比,冠心病组COX-2及QKI水平明显下降(均P<0.001).与NISR组相比,ISR组超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)、糖化血红蛋白(glycosylated hemoglobin,HbAlc)显著升高(均P<0.001),COX-2及QKI水平明显下降(均P<0.001).血浆COX-2与hs-CRP水平呈负相关(r=?0.385,P=0.003).多因素logistic回归分析发现血浆高水平QKI、COX-2是冠心病患者PCI术后ISR的保护因素,高水平hs-CRP是危险因素.ROC曲线分析显示:
AbstractList 目的:经皮冠状动脉介入术(percutaneous coronary intervention,PCI)是治疗冠心病的重要手段之一,支架植入术后发生的支架内再狭窄(in-stent restenosis,ISR)是影响冠心病患者PCI术后远期疗效及预后的重要因素.本研究旨在探讨血浆Quaking(QKI)、环氧合酶-2(cyclooxygenase-2,COX-2)水平与冠心病患者PCI术后ISR的相关性.方法:连续选取2019年9月至2020年9月在中南大学湘雅医院心血管内科行冠状动脉造影并行支架植入术的冠心病患者218例,选取同期在体检中心体检的与冠心病患者基线资料相匹配的35例个体作为对照组.入院后收集两组患者的临床资料,采用酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)测定血浆QKI、COX-2水平.术后12个月复查冠心病患者的冠状动脉造影,根据是否发生ISR将218例冠心病患者分为无再狭窄组(NISR组,n=160)与再狭窄组(ISR组,n=58).比较NISR组与ISR组的一般资料及冠状动脉临床指标,采用多因素logistic回归分析ISR的影响因素.记录1年内主要不良心血管事件(major adverse cardiovascular events,MACE)发生情况,并据此将58例PCI术后ISR患者分为未发生MACE组(34例)与发生MACE组(24例),比较两组的血浆QKI、COX-2水平,采用受试者操作特征(receiver operating characteristic,ROC)曲线探究血浆QKI、COX-2水平对PCI术后ISR及MACE的诊断价值.结果:与对照组相比,冠心病组COX-2及QKI水平明显下降(均P<0.001).与NISR组相比,ISR组超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)、糖化血红蛋白(glycosylated hemoglobin,HbAlc)显著升高(均P<0.001),COX-2及QKI水平明显下降(均P<0.001).血浆COX-2与hs-CRP水平呈负相关(r=?0.385,P=0.003).多因素logistic回归分析发现血浆高水平QKI、COX-2是冠心病患者PCI术后ISR的保护因素,高水平hs-CRP是危险因素.ROC曲线分析显示:
Author 刘昱博
高浩东
匡圆圆
马琦琳
王萍
张银妆
AuthorAffiliation 中南大学湘雅医院心血管内科,国家老年疾病临床医学研究中心(湘雅医院),长沙410008%长沙市第一医院心内科,长沙410005
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Author_FL LIU Yubo
WANG Ping
ZHANG Yinzhuang
MA Qilin
KUANG Yuanyuan
GAO Haodong
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DocumentTitle_FL Levels of plasma Quaking and cyclooxygenase-2 predict in-stent restenosis in patients with coronary artery disease after percutaneous coronary intervention
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Keywords 经皮冠状动脉介入治疗
冠心病
Quaking
支架内再狭窄
主要不良心血管事件
环氧合酶-2
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PublicationTitle 中南大学学报（医学版）
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Snippet 目的:经皮冠状动脉介入术(percutaneous coronary intervention,PCI)是治疗冠心病的重要手段之一,支架植入术后发生的支架内再狭窄(in-stent restenosis,ISR)是影响冠心病患...
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Title 血浆Quaking和环氧合酶-2水平预测冠心病患者行经皮冠状动脉介入术后支架内再狭窄
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