食管鳞状细胞癌中微管不稳定蛋白stathmin表达及其与预后的关系
R36; 目的 探讨微管不稳定蛋白stathmin在食管鳞状细胞癌中的表达水平及其与临床病理特征、预后的关系.方法 收集2007年1月至2010年12月在复旦大学附属中山医院手术切除的496例食管鳞状细胞癌患者的临床病理资料,采用免疫组织化学法检测肿瘤组织stathmin的表达情况,分析其表达差异与患者临床病理特征和预后的关系.结果 496例食管鳞状细胞癌患者中,266例为Ⅰ～Ⅱ期,230例为Ⅲ～Ⅳ期.Stathmin蛋白不表达、低表达和高表达的比例分别为2.4％、87.1％和10.5％.Stathmin高表达与肿瘤分化差相关(P=0.040).生存分析发现:stathmin高表达组患者的无疾...
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| Published in | 中国临床医学 Vol. 30; no. 1; pp. 85 - 90 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
复旦大学附属中山医院病理科,上海 200032
01.02.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-6358 |
| DOI | 10.12025/j.issn.1008-6358.2023.20222294 |
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| Abstract | R36; 目的 探讨微管不稳定蛋白stathmin在食管鳞状细胞癌中的表达水平及其与临床病理特征、预后的关系.方法 收集2007年1月至2010年12月在复旦大学附属中山医院手术切除的496例食管鳞状细胞癌患者的临床病理资料,采用免疫组织化学法检测肿瘤组织stathmin的表达情况,分析其表达差异与患者临床病理特征和预后的关系.结果 496例食管鳞状细胞癌患者中,266例为Ⅰ～Ⅱ期,230例为Ⅲ～Ⅳ期.Stathmin蛋白不表达、低表达和高表达的比例分别为2.4％、87.1％和10.5％.Stathmin高表达与肿瘤分化差相关(P=0.040).生存分析发现:stathmin高表达组患者的无疾病生存期(disease free survival,DFS)和总生存期(overall survival,OS)与不表达/低表达组相比,有预后差的趋势,但差异无统计学意义(DFS:P=0.159;OS:P=0.176).在Ⅰ～Ⅱ期患者中,stathmin高表达组比stathmin不表达/低表达组的预后差(DFS:P=0.032;OS:P=0.018);但是在Ⅲ～Ⅳ期患者中,stathmin高表达组与stathmin不表达/低表达组的预后差异无统计学意义(DFS:P=0.785;OS:P=0.613).Ⅰ～Ⅱ期中stathmin高表达患者的预后,与Ⅲ～Ⅳ期stathmin不表达/低表达患者或者高表达患者差异无统计学意义.结论 Ⅰ～Ⅱ期食管鳞状细胞癌中,stathmin高表达的患者预后差. |
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| AbstractList | R36; 目的 探讨微管不稳定蛋白stathmin在食管鳞状细胞癌中的表达水平及其与临床病理特征、预后的关系.方法 收集2007年1月至2010年12月在复旦大学附属中山医院手术切除的496例食管鳞状细胞癌患者的临床病理资料,采用免疫组织化学法检测肿瘤组织stathmin的表达情况,分析其表达差异与患者临床病理特征和预后的关系.结果 496例食管鳞状细胞癌患者中,266例为Ⅰ～Ⅱ期,230例为Ⅲ～Ⅳ期.Stathmin蛋白不表达、低表达和高表达的比例分别为2.4％、87.1％和10.5％.Stathmin高表达与肿瘤分化差相关(P=0.040).生存分析发现:stathmin高表达组患者的无疾病生存期(disease free survival,DFS)和总生存期(overall survival,OS)与不表达/低表达组相比,有预后差的趋势,但差异无统计学意义(DFS:P=0.159;OS:P=0.176).在Ⅰ～Ⅱ期患者中,stathmin高表达组比stathmin不表达/低表达组的预后差(DFS:P=0.032;OS:P=0.018);但是在Ⅲ～Ⅳ期患者中,stathmin高表达组与stathmin不表达/低表达组的预后差异无统计学意义(DFS:P=0.785;OS:P=0.613).Ⅰ～Ⅱ期中stathmin高表达患者的预后,与Ⅲ～Ⅳ期stathmin不表达/低表达患者或者高表达患者差异无统计学意义.结论 Ⅰ～Ⅱ期食管鳞状细胞癌中,stathmin高表达的患者预后差. |
| Author | 宿杰阿克苏 任磊 徐磊 蒋冬先 王海星 彭睿 侯英勇 |
| AuthorAffiliation | 复旦大学附属中山医院病理科,上海 200032 |
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| Author_FL | REN Lei HOU Ying-yong AKESU Su-jie WANG Hai-xing PENG Rui XU Lei JIANG Dong-xian |
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| Keywords | 预后 食管鳞状细胞癌 肿瘤分期 stathmin蛋白 |
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