sPD-1和sPD-Ls在结缔组织病发病机制中的作用
膜结合型程序性死亡受体1(membrane-bound programmed cell death-1,mPD-1)及膜结合型程序性死亡受体配体(membrane-bound programmed cell death-ligands,mPD-Ls)存在可溶性形式,分别为可溶性程序性死亡受体1(soluble programmed cell death-1,sPD-1)和可溶性程序性死亡受体配体(soluble programmed cell death-ligands,sPD-Ls)[包括可溶性程序性死亡受体配体1(soluble programmed cell death-ligand 1...
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| Published in | 中南大学学报（医学版） Vol. 48; no. 3; pp. 444 - 454 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
蚌埠医学院慢性疾病免疫学基础与临床安徽省重点实验室,安徽 蚌埠 233030
2023
蚌埠医学院第一附属医院风湿免疫科,安徽 蚌埠233099%蚌埠医学院临床医学系,安徽 蚌埠 233030%蚌埠医学院人体解剖学教研室,安徽 蚌埠 233030%蚌埠医学院组织学与胚胎学教研室,安徽 蚌埠 233030 蚌埠医学院显微形态实验中心,安徽 蚌埠 233030%蚌埠医学院第一附属医院风湿免疫科,安徽 蚌埠233099 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-7347 |
| DOI | 10.11817/j.issn.1672-7347.2023.220263 |
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| Abstract | 膜结合型程序性死亡受体1(membrane-bound programmed cell death-1,mPD-1)及膜结合型程序性死亡受体配体(membrane-bound programmed cell death-ligands,mPD-Ls)存在可溶性形式,分别为可溶性程序性死亡受体1(soluble programmed cell death-1,sPD-1)和可溶性程序性死亡受体配体(soluble programmed cell death-ligands,sPD-Ls)[包括可溶性程序性死亡受体配体1(soluble programmed cell death-ligand 1,sPD-L1)和可溶性程序性死亡受体配体2(soluble programmed cell death-ligand 2,sPD-L2)].sPD-1和sPD-L2主要由PD-1 mRNA的选择性剪接异构体翻译产生,而sPD-L1则是由基质金属蛋白酶(matrix metalloproteinases,MMPs)剪切膜结合型程序性死亡受体配体1(membrane-bound programmed cell death-ligand 1,mPD-L1)产生.sPD-1和sPD-Ls通过阻断mPD-1/mPD-L1通路在自身免疫调节中起重要作用,而结缔组织病(connective tissue disease,CTD)是由自身免疫反应等引起的一类疾病,并且多种自身免疫性疾病在发生、发展过程中均可出现mPD-1/mPD-L1的功能异常.故sPD-1和sPD-Ls通过阻断mPD-1/mPD-L1通路,在由自身免疫反应引起的CTD发病机制中起重要作用.了解sPD-1和sPD-Ls在CTD中的作用机制和临床价值对改善患者的生活质量具有重要的现实意义. |
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| AbstractList | 膜结合型程序性死亡受体1(membrane-bound programmed cell death-1,mPD-1)及膜结合型程序性死亡受体配体(membrane-bound programmed cell death-ligands,mPD-Ls)存在可溶性形式,分别为可溶性程序性死亡受体1(soluble programmed cell death-1,sPD-1)和可溶性程序性死亡受体配体(soluble programmed cell death-ligands,sPD-Ls)[包括可溶性程序性死亡受体配体1(soluble programmed cell death-ligand 1,sPD-L1)和可溶性程序性死亡受体配体2(soluble programmed cell death-ligand 2,sPD-L2)].sPD-1和sPD-L2主要由PD-1 mRNA的选择性剪接异构体翻译产生,而sPD-L1则是由基质金属蛋白酶(matrix metalloproteinases,MMPs)剪切膜结合型程序性死亡受体配体1(membrane-bound programmed cell death-ligand 1,mPD-L1)产生.sPD-1和sPD-Ls通过阻断mPD-1/mPD-L1通路在自身免疫调节中起重要作用,而结缔组织病(connective tissue disease,CTD)是由自身免疫反应等引起的一类疾病,并且多种自身免疫性疾病在发生、发展过程中均可出现mPD-1/mPD-L1的功能异常.故sPD-1和sPD-Ls通过阻断mPD-1/mPD-L1通路,在由自身免疫反应引起的CTD发病机制中起重要作用.了解sPD-1和sPD-Ls在CTD中的作用机制和临床价值对改善患者的生活质量具有重要的现实意义. |
| Author | 周明骏 王元元 谢长好 何豪华 代丽 谢卓贝 汤迎凯 何晓宇 |
| AuthorAffiliation | 蚌埠医学院第一附属医院风湿免疫科,安徽 蚌埠233099%蚌埠医学院临床医学系,安徽 蚌埠 233030%蚌埠医学院人体解剖学教研室,安徽 蚌埠 233030%蚌埠医学院组织学与胚胎学教研室,安徽 蚌埠 233030;蚌埠医学院显微形态实验中心,安徽 蚌埠 233030%蚌埠医学院第一附属医院风湿免疫科,安徽 蚌埠233099;蚌埠医学院慢性疾病免疫学基础与临床安徽省重点实验室,安徽 蚌埠 233030 |
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| Author_FL | XIE Zhuobei XIE Changhao TANG Yingkai WANG Yuanyuan HE Xiaoyu ZHOU Mingjun HE Haohua DAI Li |
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| DocumentTitle_FL | Role of sPD-1 and sPD-Ls in the pathogenesis of connective tissue disease |
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| Keywords | 发病机制 可溶性程序性死亡受体配体 可溶性程序性死亡受体1 结缔组织病 |
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| Snippet | 膜结合型程序性死亡受体1(membrane-bound programmed cell death-1,mPD-1)及膜结合型程序性死亡受体配体(membrane-bound programmed cell death-ligands,mPD-Ls)存在可溶... |
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| Title | sPD-1和sPD-Ls在结缔组织病发病机制中的作用 |
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