焦虑、抑郁评分对白癜风治疗效果影响的前瞻性临床研究

R758.4+1; 目的:探讨焦虑、抑郁对白癜风患者药物治疗效果的影响.方法:培训过的医务处干事作为心理研究员依据汉密尔顿焦虑量表14项(HAMA-14)和汉密尔顿抑郁量表24项(HAMD-24)在白癜风患者治疗前对其进行焦虑、抑郁评分.皮肤科医师依据病情及患者治疗意愿对白癜风患者进行分组,分为单纯外涂药物治疗(外涂治疗组,n=72)和外涂药物+口服中药或西药联合治疗(联合治疗组,n=128).将联合治疗组进一步分为联合活血合剂组(n=47)、联合甘草酸苷组(n=35)、联合活血合剂+甘草酸苷组(n=27)及联合泼尼松组(n=19).活血合剂为复旦大学附属中山医院自制中药制剂,30 mL/次、...

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Published in中国临床医学 Vol. 28; no. 6; pp. 934 - 938
Main Authors 胡飞飞, 袁虹, 季梅, 杨荞榕, 高地, 隗祎
Format Journal Article
LanguageChinese
Published 复旦大学附属中山医院皮肤科,上海 200032%复旦大学附属中山医院医务二处,上海 200032%上海市奉贤区皮肤病防治所,上海 201408 2021
Subjects
白癜风;焦虑;抑郁;心理干预
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ISSN1008-6358
DOI10.12025/j.issn.1008-6358.2021.20210970

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Abstract R758.4+1; 目的:探讨焦虑、抑郁对白癜风患者药物治疗效果的影响.方法:培训过的医务处干事作为心理研究员依据汉密尔顿焦虑量表14项(HAMA-14)和汉密尔顿抑郁量表24项(HAMD-24)在白癜风患者治疗前对其进行焦虑、抑郁评分.皮肤科医师依据病情及患者治疗意愿对白癜风患者进行分组,分为单纯外涂药物治疗(外涂治疗组,n=72)和外涂药物+口服中药或西药联合治疗(联合治疗组,n=128).将联合治疗组进一步分为联合活血合剂组(n=47)、联合甘草酸苷组(n=35)、联合活血合剂+甘草酸苷组(n=27)及联合泼尼松组(n=19).活血合剂为复旦大学附属中山医院自制中药制剂,30 mL/次、每日2次口服;甘草酸苷50 mg/次,每日3次口服;泼尼松20 mg/次、每日1次口服.进行为期3个月的临床治疗观察,对各组进行疗效指数评估,分析焦虑、抑郁评分和疗效指数的相关性.结果:纳入200例,男性69例、女性131例.外涂治疗组稳定期65例,进展期7例;联合治疗组稳定期44例,进展期84例.200例患者均完成了为期3个月的临床观察,观察期内均未出现严重不良反应.Spearman相关系数分析结果显示,焦虑、抑郁与各治疗方法疗效指数均负相关(P<0.05).结论:对于白癜风患者,无论是单纯应用外涂药物还是外涂药物联合口服中药或西药联合治疗,焦虑、抑郁状态均会降低疗效.
AbstractList R758.4+1; 目的:探讨焦虑、抑郁对白癜风患者药物治疗效果的影响.方法:培训过的医务处干事作为心理研究员依据汉密尔顿焦虑量表14项(HAMA-14)和汉密尔顿抑郁量表24项(HAMD-24)在白癜风患者治疗前对其进行焦虑、抑郁评分.皮肤科医师依据病情及患者治疗意愿对白癜风患者进行分组,分为单纯外涂药物治疗(外涂治疗组,n=72)和外涂药物+口服中药或西药联合治疗(联合治疗组,n=128).将联合治疗组进一步分为联合活血合剂组(n=47)、联合甘草酸苷组(n=35)、联合活血合剂+甘草酸苷组(n=27)及联合泼尼松组(n=19).活血合剂为复旦大学附属中山医院自制中药制剂,30 mL/次、每日2次口服;甘草酸苷50 mg/次,每日3次口服;泼尼松20 mg/次、每日1次口服.进行为期3个月的临床治疗观察,对各组进行疗效指数评估,分析焦虑、抑郁评分和疗效指数的相关性.结果:纳入200例,男性69例、女性131例.外涂治疗组稳定期65例,进展期7例;联合治疗组稳定期44例,进展期84例.200例患者均完成了为期3个月的临床观察,观察期内均未出现严重不良反应.Spearman相关系数分析结果显示,焦虑、抑郁与各治疗方法疗效指数均负相关(P<0.05).结论:对于白癜风患者,无论是单纯应用外涂药物还是外涂药物联合口服中药或西药联合治疗,焦虑、抑郁状态均会降低疗效.
Author 袁虹
季梅
杨荞榕
高地
隗祎
胡飞飞
AuthorAffiliation 复旦大学附属中山医院皮肤科,上海 200032%复旦大学附属中山医院医务二处,上海 200032%上海市奉贤区皮肤病防治所,上海 201408
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YANG Qiao-rong
JI Mei
HU Fei-fei
YUAN Hong
WEI Yi
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Snippet R758.4+1; 目的:探讨焦虑、抑郁对白癜风患者药物治疗效果的影响.方法:培训过的医务处干事作为心理研究员依据汉密尔顿焦虑量表14项(HAMA-14)和汉密尔顿抑郁量表24...
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Title 焦虑、抑郁评分对白癜风治疗效果影响的前瞻性临床研究
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