肝癌患者肝移植术前使用PD-1抑制剂对移植后排斥反应的影响

R735.7; 目的:观察肝癌患者肝移植术前使用PD-1抑制剂对肝移植术后排斥反应的影响.方法:选取2019年1月1日至2019年12月31日在复旦大学附属中山医院行肝移植且移植前接受过PD-1抑制剂治疗的肝癌患者,共12例.检测其术后早期他克莫司药物浓度,观察移植术后排斥反应发生情况.结果:术后第1周和第2周他克莫司浓度分别为(5.14±2.68)ng/mL和(8.41±5.73)ng/mL.16.7％(2/12)患者发生细胞性排斥.结论:肝移植术前使用PD-1抑制剂的肝癌患者,其移植术后排斥反应的发生率未见明显增加....

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Published in中国临床医学 Vol. 27; no. 3; pp. 444 - 447
Main Authors 崔春晓, 杨柳晓, 王颖, 黄俊峰, 黄晓武, 樊嘉, 周俭, 王婷
Format Journal Article
LanguageChinese
Published 复旦大学附属中山医院肝移植重症监护室,上海,200032%复旦大学附属中山医院(肝癌研究所)肝外科,上海,200032 01.06.2020
Subjects
PD-1抑制剂
肝移植
排斥
肝癌
Online AccessGet full text
ISSN1008-6358
DOI10.12025/j.issn.1008-6358.2020.20201005

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Abstract R735.7; 目的:观察肝癌患者肝移植术前使用PD-1抑制剂对肝移植术后排斥反应的影响.方法:选取2019年1月1日至2019年12月31日在复旦大学附属中山医院行肝移植且移植前接受过PD-1抑制剂治疗的肝癌患者,共12例.检测其术后早期他克莫司药物浓度,观察移植术后排斥反应发生情况.结果:术后第1周和第2周他克莫司浓度分别为(5.14±2.68)ng/mL和(8.41±5.73)ng/mL.16.7％(2/12)患者发生细胞性排斥.结论:肝移植术前使用PD-1抑制剂的肝癌患者,其移植术后排斥反应的发生率未见明显增加.
AbstractList R735.7; 目的:观察肝癌患者肝移植术前使用PD-1抑制剂对肝移植术后排斥反应的影响.方法:选取2019年1月1日至2019年12月31日在复旦大学附属中山医院行肝移植且移植前接受过PD-1抑制剂治疗的肝癌患者,共12例.检测其术后早期他克莫司药物浓度,观察移植术后排斥反应发生情况.结果:术后第1周和第2周他克莫司浓度分别为(5.14±2.68)ng/mL和(8.41±5.73)ng/mL.16.7％(2/12)患者发生细胞性排斥.结论:肝移植术前使用PD-1抑制剂的肝癌患者,其移植术后排斥反应的发生率未见明显增加.
Author 樊嘉
王婷
黄俊峰
王颖
黄晓武
崔春晓
杨柳晓
周俭
AuthorAffiliation 复旦大学附属中山医院肝移植重症监护室,上海,200032%复旦大学附属中山医院(肝癌研究所)肝外科,上海,200032
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Author_FL YANG Liu-xiao
HUANG Jun-feng
CUI Chun-xiao
HUANG Xiao-wu
ZHOU Jian
WANG Ting
WANG Ying
FAN Jia
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肝移植
排斥
肝癌
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Snippet R735.7; 目的:观察肝癌患者肝移植术前使用PD-1抑制剂对肝移植术后排斥反应的影响.方法:选取2019年1月1日至2019年12月31日在复旦大学附属中山医院行肝移植且移植前接受...
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StartPage 444
Title 肝癌患者肝移植术前使用PD-1抑制剂对移植后排斥反应的影响
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