糖化血红蛋白变异指数对2型糖尿病患者发生高尿酸血症的预测价值研究
R587.1; 背景 糖化血红蛋白变异指数(HGI)是一种衡量血红蛋白糖化程度的简易指标,与糖尿病微血管和大血管病变等多种慢性并发症密切相关,但目前国内外关于HGI与2型糖尿病(T2DM)患者高尿酸血症(HUA)发生情况的关系研究较少.目的 探讨HGI对T2DM患者发生HUA的预测价值.方法 选取2017年1月至2021年1月于西南医科大学附属医院内分泌科就诊并建立档案的符合研究标准的1194例T2DM患者为研究对象.记录患者基本信息、体格检查指标、实验室检查指标,计算HGI.根据HGI三分位数法将研究对象分为低HGI组(HGI<-0.94％)、中HGI组(-0.94％≤HGI<0...
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| Published in | 中国全科医学 Vol. 25; no. 6; pp. 693 - 698 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
646000 四川省泸州市,西南医科大学附属医院内分泌科
20.02.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1007-9572 |
| DOI | 10.12114/j.issn.1007-9572.2021.02.126 |
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| Abstract | R587.1; 背景 糖化血红蛋白变异指数(HGI)是一种衡量血红蛋白糖化程度的简易指标,与糖尿病微血管和大血管病变等多种慢性并发症密切相关,但目前国内外关于HGI与2型糖尿病(T2DM)患者高尿酸血症(HUA)发生情况的关系研究较少.目的 探讨HGI对T2DM患者发生HUA的预测价值.方法 选取2017年1月至2021年1月于西南医科大学附属医院内分泌科就诊并建立档案的符合研究标准的1194例T2DM患者为研究对象.记录患者基本信息、体格检查指标、实验室检查指标,计算HGI.根据HGI三分位数法将研究对象分为低HGI组(HGI<-0.94％)、中HGI组(-0.94％≤HGI<0.27％)和高HGI组(HGI≥0.27％).采用多因素Logistic回归分析探究T2DM患者发生HUA的影响因素.绘制HGI联合临床指标预测T2DM患者发生HUA的受试者工作特征(ROC)曲线.结果 低HGI组、中HGI组和高HGI组T2DM患者HUA的发生率分别为17.09％(68/398)、27.14％(108/398)和31.66％(126/398).中HGI组和高HGI组患者HUA发生率均高于低HGI组(χ2值分别为11.672、22.928,P<0.01).多因素Logistic回归分析结果显示,年龄〔OR=1.048,95％CI(1.029,1.067)〕、皮下脂肪面积(SFA)〔OR=1.006,95％CI(1.001,1.010)〕、三酰甘油(TG)〔OR=1.096,95％CI(1.034,1.161)〕、高密度脂蛋白胆固醇(HDL-C)〔OR=0.560,95％CI(0.326,0.961)〕、HGI〔OR=1.360,95％CI(1.208,1.531)〕是T2DM患者发生HUA的独立影响因素(P<0.05).校正年龄、SFA、TG、HDL-C影响因素后的多因素Logistic回归分析结果显示,中HGI组患者发生HUA的风险是低HGI组的1.855倍〔95％CI(1.283,2.681),P<0.001〕,高HGI组患者发生HUA的风险是低HGI组的2.192倍〔95％CI(1.530,3.141),P<0.001〕.HGI联合临床指标〔Logit(P)=-4.549+0.618×中HGI组+0.785×高HGI组+0.039×年龄+0.008×SFA+0.088×TG-0.750×HDL-C〕诊断T2DM患者 |
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| AbstractList | R587.1; 背景 糖化血红蛋白变异指数(HGI)是一种衡量血红蛋白糖化程度的简易指标,与糖尿病微血管和大血管病变等多种慢性并发症密切相关,但目前国内外关于HGI与2型糖尿病(T2DM)患者高尿酸血症(HUA)发生情况的关系研究较少.目的 探讨HGI对T2DM患者发生HUA的预测价值.方法 选取2017年1月至2021年1月于西南医科大学附属医院内分泌科就诊并建立档案的符合研究标准的1194例T2DM患者为研究对象.记录患者基本信息、体格检查指标、实验室检查指标,计算HGI.根据HGI三分位数法将研究对象分为低HGI组(HGI<-0.94％)、中HGI组(-0.94％≤HGI<0.27％)和高HGI组(HGI≥0.27％).采用多因素Logistic回归分析探究T2DM患者发生HUA的影响因素.绘制HGI联合临床指标预测T2DM患者发生HUA的受试者工作特征(ROC)曲线.结果 低HGI组、中HGI组和高HGI组T2DM患者HUA的发生率分别为17.09％(68/398)、27.14％(108/398)和31.66％(126/398).中HGI组和高HGI组患者HUA发生率均高于低HGI组(χ2值分别为11.672、22.928,P<0.01).多因素Logistic回归分析结果显示,年龄〔OR=1.048,95％CI(1.029,1.067)〕、皮下脂肪面积(SFA)〔OR=1.006,95％CI(1.001,1.010)〕、三酰甘油(TG)〔OR=1.096,95％CI(1.034,1.161)〕、高密度脂蛋白胆固醇(HDL-C)〔OR=0.560,95％CI(0.326,0.961)〕、HGI〔OR=1.360,95％CI(1.208,1.531)〕是T2DM患者发生HUA的独立影响因素(P<0.05).校正年龄、SFA、TG、HDL-C影响因素后的多因素Logistic回归分析结果显示,中HGI组患者发生HUA的风险是低HGI组的1.855倍〔95％CI(1.283,2.681),P<0.001〕,高HGI组患者发生HUA的风险是低HGI组的2.192倍〔95％CI(1.530,3.141),P<0.001〕.HGI联合临床指标〔Logit(P)=-4.549+0.618×中HGI组+0.785×高HGI组+0.039×年龄+0.008×SFA+0.088×TG-0.750×HDL-C〕诊断T2DM患者 |
| Author | 李航 柳怡莹 万沁 林洁 刘遥 |
| AuthorAffiliation | 646000 四川省泸州市,西南医科大学附属医院内分泌科 |
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| Author_FL | LIN Jie LI Hang LIU Yiying LIU Yao WAN Qin |
| Author_FL_xml | – sequence: 1 fullname: LI Hang – sequence: 2 fullname: LIU Yiying – sequence: 3 fullname: LIU Yao – sequence: 4 fullname: LIN Jie – sequence: 5 fullname: WAN Qin |
| Author_xml | – sequence: 1 fullname: 李航 – sequence: 2 fullname: 柳怡莹 – sequence: 3 fullname: 刘遥 – sequence: 4 fullname: 林洁 – sequence: 5 fullname: 万沁 |
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| Keywords | 糖尿病,2型;高尿酸血症;糖化血红蛋白变异指数;预测价值 |
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