蒿本内酯对葡聚糖硫酸钠诱导的溃疡性结肠炎小鼠的改善作用
R459.3; 目的:探究蒿本内酯(ligustilide,Lig)对葡聚糖硫酸钠(dextran sodium sulfate,DSS)诱导溃疡性结肠炎(ulcerative colitis,UC)小鼠的改善作用及机制.方法:将 60只雄性SPF级C57BL/6小鼠随机分成 6组,分别为空白组、DSS组、阳性药柳氮磺吡啶(sulfasalazine,SASP)组、Lig低、中、高剂量组.DSS组小鼠自由饮用3%DSS水溶液 7d复制UC模型,同时对Lig低、中、高剂量组小鼠灌胃给予药物干预治疗.通过记录小鼠每日体重和结肠长度,检测疾病活动指数(disease activity index,D...
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| Published in | 食品工业科技 Vol. 45; no. 4; pp. 321 - 327 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
许昌职业技术学医疗卫生学院,河南许昌 461000%河南科技大学食品与生物工程学院,河南洛阳 471000
01.02.2024
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1002-0306 |
| DOI | 10.13386/j.issn1002-0306.2023040055 |
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| Abstract | R459.3; 目的:探究蒿本内酯(ligustilide,Lig)对葡聚糖硫酸钠(dextran sodium sulfate,DSS)诱导溃疡性结肠炎(ulcerative colitis,UC)小鼠的改善作用及机制.方法:将 60只雄性SPF级C57BL/6小鼠随机分成 6组,分别为空白组、DSS组、阳性药柳氮磺吡啶(sulfasalazine,SASP)组、Lig低、中、高剂量组.DSS组小鼠自由饮用3%DSS水溶液 7d复制UC模型,同时对Lig低、中、高剂量组小鼠灌胃给予药物干预治疗.通过记录小鼠每日体重和结肠长度,检测疾病活动指数(disease activity index,DAI)评分,采用酶联免疫吸附测定试剂盒定量检测血清中TNF-α、IL-6和IL-1β的表达水平,检测结肠中TLR4/NF-κB蛋白表达水平,并结合苏木素-伊红染色实验,探究Lig对小鼠UC的作用及机制.结果:与空白组比较,DSS组小鼠体重显著减轻(P<0.05),结肠长度显著缩短(P<0.05),DAI评分显著升高(P<0.05),肠道出现大量炎症性浸润现象,且结肠组织中TNF-α、IL-6和IL-1β表达水平显著升高(P<0.05);与DSS组比较,Lig中剂量组和高剂量组小鼠的肠道组织中TNF-α、IL-6和IL-1β的表达以及TLR4/NF-κB信号均被显著抑制(P<0.05),表明Lig中剂量组和高剂量组小鼠肠道损伤得到显著改善.结论:Lig能有效改善DSS诱导的小鼠UC,其机制可能是抑制NF-κB信号通路的激活. |
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| AbstractList | R459.3; 目的:探究蒿本内酯(ligustilide,Lig)对葡聚糖硫酸钠(dextran sodium sulfate,DSS)诱导溃疡性结肠炎(ulcerative colitis,UC)小鼠的改善作用及机制.方法:将 60只雄性SPF级C57BL/6小鼠随机分成 6组,分别为空白组、DSS组、阳性药柳氮磺吡啶(sulfasalazine,SASP)组、Lig低、中、高剂量组.DSS组小鼠自由饮用3%DSS水溶液 7d复制UC模型,同时对Lig低、中、高剂量组小鼠灌胃给予药物干预治疗.通过记录小鼠每日体重和结肠长度,检测疾病活动指数(disease activity index,DAI)评分,采用酶联免疫吸附测定试剂盒定量检测血清中TNF-α、IL-6和IL-1β的表达水平,检测结肠中TLR4/NF-κB蛋白表达水平,并结合苏木素-伊红染色实验,探究Lig对小鼠UC的作用及机制.结果:与空白组比较,DSS组小鼠体重显著减轻(P<0.05),结肠长度显著缩短(P<0.05),DAI评分显著升高(P<0.05),肠道出现大量炎症性浸润现象,且结肠组织中TNF-α、IL-6和IL-1β表达水平显著升高(P<0.05);与DSS组比较,Lig中剂量组和高剂量组小鼠的肠道组织中TNF-α、IL-6和IL-1β的表达以及TLR4/NF-κB信号均被显著抑制(P<0.05),表明Lig中剂量组和高剂量组小鼠肠道损伤得到显著改善.结论:Lig能有效改善DSS诱导的小鼠UC,其机制可能是抑制NF-κB信号通路的激活. |
| Abstract_FL | Objective:To research the therapeutic effects and mechanisms of ligustilide(Lig)in improving dextran sodium sulfate(DSS)-induced ulcerative colitis(UC)in mice.Methods:Intervention of lig was delivered in sixty male SPF C57 BL/6 mice and the mice were differentiated in six groups according to the dose of lig as:Control group,DSS group,positive control group(treated with sulfasalazine,SASP),low-dose lig group,medium-dose lig group,and high-dose lig group.The UC in DSS mice was induced by a 3%DSS solution through oral administration for 7 days,in the meanwhile,the low,medium,and high-dose lig groups were received gavage feeding of lig and oral administration of 3%DSS solution.Before and after the intervention,the body weight,colon length,and the disease activity index(DAI)score were collected for assessment of UC.Furthermore,the expression levels of TLR4/NF-κB proteins in colon and serum TNF-α,IL-6,and IL-1β were quantitatively measured using enzyme-linked immunosorbent(ELISA)assays.Additionally,histological exam-ination was performed to investigate the effects and mechanisms of lig in improving UC in mice by hematoxylin-eosin staining.Results:Compared to the control group,significantly reduced body weight(P<0.05),shorter colon length(P<0.05),increased DAI score(P<0.05).And there was a large amount of inflammatory infiltration in the intestine,the expression level of TNF-α,IL-6,and IL-1β in the colon significantly increased(P<0.05).Compared with DSS group,significant suppression of the TLR4/NF-κB signaling pathway in the intestinal tissue,serum TNF-α,IL-6,and IL-1β expression(P<0.05)were observed in the medium and high-dose lig groups,which indicated a significant improvement in intestinal damage.Conclusion:Lig would be able to effectively improve DSS-induced UC in mice.Moreover,the results showed that the mechanism of lig improving DSS-induced UC was possibly involved with the inhibition of the NF-κB signaling pathway. |
| Author | 马金亮 马广礼 夏晓培 |
| AuthorAffiliation | 许昌职业技术学医疗卫生学院,河南许昌 461000%河南科技大学食品与生物工程学院,河南洛阳 471000 |
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| Author_FL | MA Jinliang MA Guangli XIA Xiaopei |
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| ClassificationCodes | R459.3 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| DocumentTitle_FL | Improving Effect of Ligustilide on Dextran Sodium Sulfate-induced Ulcerative Colitis |
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| Keywords | 蒿本内酯 inflammatory factor 溃疡性结肠炎 葡聚糖硫酸钠 炎症因子 ulcerative colitis dextran sodium sulfate ligustilide |
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