二氢杨梅素及其酰化衍生物对肝细胞氧化损伤的保护作用
目的:考察二氢杨梅素(DHM)及其衍生物对肝细胞氧化损伤的保护作用.方法:建立L02细胞过氧化氢损伤模型,通过酶法酰化修饰DHM得到不同亲脂性的DHM衍生物,再通过测定活性氧(ROS)、乳酸脱氢酶(LDH)、丙二醛(MDA)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)水平、线粒体膜电位和Caspase 3水平评估DHM及其衍生物对肝损伤细胞的保护作用.结果:除3-O-月桂酰化二氢杨梅素外,其余衍生物处理后的肝损伤细胞中活性氧(ROS)、乳酸脱氢酶(LDH)的释放和丙二醛(MDA)水平显著降低,抗氧化酶系水平升高,线粒体膜电位升高,Caspase 3水平降...
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| Published in | 食品与机械 Vol. 38; no. 6; pp. 30 - 150 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
江南大学食品科学与技术国家重点实验室,江苏无锡 214122%江南大学食品学院,江苏无锡 214122
01.06.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1003-5788 |
| DOI | 10.13652/j.spjx.1003.5788.2022.60036 |
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| Abstract | 目的:考察二氢杨梅素(DHM)及其衍生物对肝细胞氧化损伤的保护作用.方法:建立L02细胞过氧化氢损伤模型,通过酶法酰化修饰DHM得到不同亲脂性的DHM衍生物,再通过测定活性氧(ROS)、乳酸脱氢酶(LDH)、丙二醛(MDA)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)水平、线粒体膜电位和Caspase 3水平评估DHM及其衍生物对肝损伤细胞的保护作用.结果:除3-O-月桂酰化二氢杨梅素外,其余衍生物处理后的肝损伤细胞中活性氧(ROS)、乳酸脱氢酶(LDH)的释放和丙二醛(MDA)水平显著降低,抗氧化酶系水平升高,线粒体膜电位升高,Caspase 3水平降低,其中 3-O-辛酰化二氢杨梅素的保护效果最好.结论:中等链长二氢杨梅素衍生物有较好的护肝效果. |
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| AbstractList | 目的:考察二氢杨梅素(DHM)及其衍生物对肝细胞氧化损伤的保护作用.方法:建立L02细胞过氧化氢损伤模型,通过酶法酰化修饰DHM得到不同亲脂性的DHM衍生物,再通过测定活性氧(ROS)、乳酸脱氢酶(LDH)、丙二醛(MDA)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)水平、线粒体膜电位和Caspase 3水平评估DHM及其衍生物对肝损伤细胞的保护作用.结果:除3-O-月桂酰化二氢杨梅素外,其余衍生物处理后的肝损伤细胞中活性氧(ROS)、乳酸脱氢酶(LDH)的释放和丙二醛(MDA)水平显著降低,抗氧化酶系水平升高,线粒体膜电位升高,Caspase 3水平降低,其中 3-O-辛酰化二氢杨梅素的保护效果最好.结论:中等链长二氢杨梅素衍生物有较好的护肝效果. |
| Author | 朱松 李玥 杜宝双 陈尚卫 |
| AuthorAffiliation | 江南大学食品科学与技术国家重点实验室,江苏无锡 214122%江南大学食品学院,江苏无锡 214122 |
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| Author_FL | CHEN Shang-wei LI Yue DU Bao-shuang ZHU Song |
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| Keywords | 衍生物 二氢杨梅素 氧化损伤 肝细胞 |
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| Publisher | 江南大学食品科学与技术国家重点实验室,江苏无锡 214122%江南大学食品学院,江苏无锡 214122 |
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| Title | 二氢杨梅素及其酰化衍生物对肝细胞氧化损伤的保护作用 |
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