化疗早期最大标准摄取值变化率Deauville评分联合C－myc基因重排对弥漫性大B细胞淋巴瘤的预后预测价值
目的:探讨化疗早期 18F－脱氧葡萄糖(FDG)正电子发射型计算机断层扫描(PET/CT)显像最大标准摄取值变化率(ΔSUVmax%)、Deauville评分和C－myc基因重排对弥漫性大B细胞淋巴瘤(DLBCL)的预后预测价值。 方法:2010年9月至2016年12月山西省肿瘤医院收治的、经病理证实的原发DLBCL患者83例，分别于化疗前1周和化疗早期(34例在化疗1个周期后的17~21 d，49例在化疗2个周期后的17~21 d)行 18F－FDG PET/CT扫描。勾画感兴趣区，计算治疗前后ΔSUVmax%。采用Deauville 5分法对患者化疗早期的PET/CT图像进行评分。采用原位...
Saved in:
| Published in | 中华肿瘤杂志 Vol. 44; no. 8; pp. 858 - 864 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
山西省肿瘤医院PET/CT室，太原 030013%山西省肿瘤医院血液科，太原 030013%山西省肿瘤医院病理科，太原 030013
23.08.2022
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-3766 |
| DOI | 10.3760/cma.j.cn112152-20200515-00452 |
Cover
| Abstract | 目的:探讨化疗早期
18F－脱氧葡萄糖(FDG)正电子发射型计算机断层扫描(PET/CT)显像最大标准摄取值变化率(ΔSUVmax%)、Deauville评分和C－myc基因重排对弥漫性大B细胞淋巴瘤(DLBCL)的预后预测价值。
方法:2010年9月至2016年12月山西省肿瘤医院收治的、经病理证实的原发DLBCL患者83例，分别于化疗前1周和化疗早期(34例在化疗1个周期后的17~21 d，49例在化疗2个周期后的17~21 d)行
18F－FDG PET/CT扫描。勾画感兴趣区，计算治疗前后ΔSUVmax%。采用Deauville 5分法对患者化疗早期的PET/CT图像进行评分。采用原位荧光杂交检测C－myc基因重排情况。随访时间为36~111个月，研究终点为无进展生存时间(PFS)。采用受试者工作特征(ROC)曲线分析、
χ2检验、Spearman相关分析、Log rank检验、Cox比例风险模型进行统计分析。
结果:83例DLBCL患者中，19例在随访期内进展。化疗早期预测肿瘤进展的最佳界值ΔSUVmax%为62.59%，Deauville评分取5分，两种方法的灵敏度、特异度、准确性差异均无统计学意义(均
P>0.05)。化疗早期ΔSUVmax%与Deauville评分、C－myc基因重排均呈负相关(
rs分别为－0.889和－0.862，均
P<0.001)，Deauville评分与C－myc基因重排呈正相关(
rs＝0.781，
P<0.001)。ΔSUVmax%≥62.59%组(57例)和<62.59%组(26例)的中位PFS分别为59.0和16.0个月，差异有统计学意义(
P<0.001)。Deauville评分<5分组(61例)和＝5分组(22例)的中位PFS分别为59.0和15.0个月，两组差异有统计学意义(
P<0.001)。C－myc基因重排阴性组(62例)和阳性组(21例)的中位PFS分别为59.0和15.0个月，两组差异有统计学意义(
P<0.001)。ΔSUVmax%<62.59%并Deauvulle评分＝5分组、ΔSUVmax%<62.59%并C－myc基因重排阳性组、Deauville评分＝5分并C－myc基因重排阳性组患者的中位PFS分别为15.5、15.0和13.5个月，明显差于其他亚组(均
P<0.001)。
结论:化疗早期ΔSUVmax%、Deauville评分和C－m |
|---|---|
| AbstractList | 目的:探讨化疗早期
18F－脱氧葡萄糖(FDG)正电子发射型计算机断层扫描(PET/CT)显像最大标准摄取值变化率(ΔSUVmax%)、Deauville评分和C－myc基因重排对弥漫性大B细胞淋巴瘤(DLBCL)的预后预测价值。
方法:2010年9月至2016年12月山西省肿瘤医院收治的、经病理证实的原发DLBCL患者83例，分别于化疗前1周和化疗早期(34例在化疗1个周期后的17~21 d，49例在化疗2个周期后的17~21 d)行
18F－FDG PET/CT扫描。勾画感兴趣区，计算治疗前后ΔSUVmax%。采用Deauville 5分法对患者化疗早期的PET/CT图像进行评分。采用原位荧光杂交检测C－myc基因重排情况。随访时间为36~111个月，研究终点为无进展生存时间(PFS)。采用受试者工作特征(ROC)曲线分析、
χ2检验、Spearman相关分析、Log rank检验、Cox比例风险模型进行统计分析。
结果:83例DLBCL患者中，19例在随访期内进展。化疗早期预测肿瘤进展的最佳界值ΔSUVmax%为62.59%，Deauville评分取5分，两种方法的灵敏度、特异度、准确性差异均无统计学意义(均
P>0.05)。化疗早期ΔSUVmax%与Deauville评分、C－myc基因重排均呈负相关(
rs分别为－0.889和－0.862，均
P<0.001)，Deauville评分与C－myc基因重排呈正相关(
rs＝0.781，
P<0.001)。ΔSUVmax%≥62.59%组(57例)和<62.59%组(26例)的中位PFS分别为59.0和16.0个月，差异有统计学意义(
P<0.001)。Deauville评分<5分组(61例)和＝5分组(22例)的中位PFS分别为59.0和15.0个月，两组差异有统计学意义(
P<0.001)。C－myc基因重排阴性组(62例)和阳性组(21例)的中位PFS分别为59.0和15.0个月，两组差异有统计学意义(
P<0.001)。ΔSUVmax%<62.59%并Deauvulle评分＝5分组、ΔSUVmax%<62.59%并C－myc基因重排阳性组、Deauville评分＝5分并C－myc基因重排阳性组患者的中位PFS分别为15.5、15.0和13.5个月，明显差于其他亚组(均
P<0.001)。
结论:化疗早期ΔSUVmax%、Deauville评分和C－m |
| Abstract_FL | Objective:To explore the prognostic value of the maximum standardized uptake value reduction proportion (ΔSUVmax%) on
18F-fluorodeoxyglucose (FDG) positron emission tomography combined with computed tomography (PET/CT) imaging, Deauville scores and C-myc gene rearrangement for the prediction of diffuse large B-cell lymphoma (DLBCL) in early chemotherapy.
Methods:A total of 83 primary patients with pathologically confirmed DLBCL admitted in Shanxi Provincial Cancer Hospital from September 2010 to December 2016 underwent
18F-FDG PET/CT 1 week before and after early chemotherapy. The patients underwent post-chemotherapy examinations between 17 to 21 days after one cycle (
n=34) or two cycles (
n=49). The region of interest (ROI) was drawn and the ΔSUVmax% was calculated. Deauville 5-point scale was used to score the PET/CT imaging in early chemotherapy. Fluorescence in situ hybridization (FISH) was used to detect C-myc gene rearrangement. The follow-up time was from 36 to 111 months. The primary end-point of the study was progression-free survival (PFS). Receiver operating characteristic (ROC) analysis,
χ2 test, Spearman correlation analysis, Log rank test, and Cox regression analysis were used to analyze the data.
Results:Of 83 DLBCL patients, 19 progressed during the follow-up period. The optimal cut-off value of ΔSUVmax% for predicting tumor progression in early chemotherapy was 62.59%, and the Deauville score was taken as 5. The differences in sensitivity, specificity, and accuracy between the two methods were not statistically significant (
P>0.05). The ΔSUVmax% were negatively correlated with C-myc gene rearrangement and the Deauville scores (
rs= -0.889, -0.862,
P<0.001). However, the Deauville scores was positively correlated with the C-myc gene rearrangement (
rs=0.781,
P<0.001). The median PFS were 59 months and 16 months in ΔSUVmax%≥62.59% (
n=57) and ΔSUVmax%<62.59% (
n=26), respectively, with significant difference (
P<0.001). The median PFS for the Deauville score <5 subgroup (61 cases) and =5 subgroup (22 cases) was 59.0 and 15.0 months, respectively, with statistically significant differences (
P<0.001). The median PFS for patients with C-myc rearrangement subgroup (62 cases) and without rearrangement subgroup (21 cases) was 59.0 and 15.0 months, respectively, with statistically significant differences (
P<0.001). The median PFS for ΔSUVmax%<62.59% and Deauville score=5 subgroup, ΔSUVmax%<62.59% and C-myc rearrangement subgroup, Deauville score=5 and C-myc rearrangement subgroup were 15.5 months, 15 months and 13.5 months, respectively, with statistically significant differences (
P<0.001).
Conclusion:ΔSUVmax%, Deauville score and C-myc gene rearrangement in early chemotherapy are all associated with PFS in DLBCL patients, and the combination of the two has a good predictive value for the prognosis of DLBCL |
| Author | 郭芳 原凌 田蓉蓉 赵铭 苏丽萍 薄云峰 林艳梅 |
| AuthorAffiliation | 山西省肿瘤医院PET/CT室，太原 030013%山西省肿瘤医院血液科，太原 030013%山西省肿瘤医院病理科，太原 030013 |
| AuthorAffiliation_xml | – name: 山西省肿瘤医院PET/CT室，太原 030013%山西省肿瘤医院血液科，太原 030013%山西省肿瘤医院病理科，太原 030013 |
| Author_FL | Su Liping Yuan Ling Tian Rongrong Bo Yunfeng Guo Fang Lin Yanmei Zhao Ming |
| Author_FL_xml | – sequence: 1 fullname: Yuan Ling – sequence: 2 fullname: Zhao Ming – sequence: 3 fullname: Su Liping – sequence: 4 fullname: Tian Rongrong – sequence: 5 fullname: Bo Yunfeng – sequence: 6 fullname: Lin Yanmei – sequence: 7 fullname: Guo Fang |
| Author_xml | – sequence: 1 fullname: 原凌 – sequence: 2 fullname: 赵铭 – sequence: 3 fullname: 苏丽萍 – sequence: 4 fullname: 田蓉蓉 – sequence: 5 fullname: 薄云峰 – sequence: 6 fullname: 林艳梅 – sequence: 7 fullname: 郭芳 |
| BookMark | eNotkE9LAkEAxedgkJkfw-PazM7O7nos-wtClzrL7DZbiq7QYpEnI3EF808RKiUpYUh08FJIuR-nmdVTX6GNurx3eI_3g7cCQnbBZgDEEIxjTYVrZp7Gs3HTRkhGRJZkKENIEJEgVIgcAmEoEywFTXUZRB0nY0CiE01JIC0Mqvy643e6ovsi-gPRL_PRWAxd7lbFTYW3Orzs8Vbvt9N0NxktnmVyOTafVHitOr-84-1a8ttr5C9MPvjkD8OF2xDNWz754N6z8F5FeRzMbfiz6vzqUUzrfPrm90b-fWXxVOHtZqDivf41mwaQVbBk0ZzDov8eAYfbWwfJXSm1v7OXXE9JDoJQlxRG1YSmMKZgqMGEpmFDl00dMwvpjFnUMhSLqPjIoIrFEjBINWSaFiWmighWEI6A2N_uObUtah-ns4XiqR0Q06WTUi44ToZ6AMI_1hySUQ |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3760/cma.j.cn112152-20200515-00452 |
| DatabaseName | Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitle_FL | Prognostic value of maximum standardized uptake value reduction proportion, Deauville score combined with C-myc gene rearrangement for the prediction of diffuse large B-cell lymphoma in early chemotherapy |
| EndPage | 864 |
| ExternalDocumentID | zhzl202208008 |
| GroupedDBID | --- -05 123 2B. 4A8 92F 92I 93N ABDBF ABJNI ACGFS ACUHS ALMA_UNASSIGNED_HOLDINGS CCEZO CIEJG CW9 EOJEC OBODZ PSX TCJ TGQ U1G U5O |
| ID | FETCH-LOGICAL-s1008-4ea6974ee430709773b82c83ef18eefafb4f563dba4fe903b871ccfa5c6153413 |
| ISSN | 0253-3766 |
| IngestDate | Thu May 29 04:03:17 EDT 2025 |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 8 |
| Keywords | Chemotherapy Prognosis 淋巴瘤，大B细胞，弥漫性 化学疗法 Positron emission tomography combined with computed tomography 预后 C－myc基因 Lymphoma, large B-cell, diffuse 正电子发射型计算机断层扫描 C-myc gene |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-s1008-4ea6974ee430709773b82c83ef18eefafb4f563dba4fe903b871ccfa5c6153413 |
| PageCount | 7 |
| ParticipantIDs | wanfang_journals_zhzl202208008 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-08-23 |
| PublicationDateYYYYMMDD | 2022-08-23 |
| PublicationDate_xml | – month: 08 year: 2022 text: 2022-08-23 day: 23 |
| PublicationDecade | 2020 |
| PublicationTitle | 中华肿瘤杂志 |
| PublicationTitle_FL | Chinese Journal of Oncology |
| PublicationYear | 2022 |
| Publisher | 山西省肿瘤医院PET/CT室，太原 030013%山西省肿瘤医院血液科，太原 030013%山西省肿瘤医院病理科，太原 030013 |
| Publisher_xml | – name: 山西省肿瘤医院PET/CT室，太原 030013%山西省肿瘤医院血液科，太原 030013%山西省肿瘤医院病理科，太原 030013 |
| SSID | ssib058574917 ssib051368316 ssib007279245 ssib000995398 ssj0042033 ssib006576341 ssib001103529 |
| Score | 2.3769183 |
| Snippet | 目的:探讨化疗早期
18F－脱氧葡萄糖(FDG)正电子发射型计算机断层扫描(PET/CT)显像最大标准摄取值变化率(ΔSUVmax%)、Deauville评分和C－myc基因重排对弥漫性大B细胞淋巴... |
| SourceID | wanfang |
| SourceType | Aggregation Database |
| StartPage | 858 |
| Title | 化疗早期最大标准摄取值变化率Deauville评分联合C－myc基因重排对弥漫性大B细胞淋巴瘤的预后预测价值 |
| URI | https://d.wanfangdata.com.cn/periodical/zhzl202208008 |
| Volume | 44 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate issn: 0253-3766 databaseCode: ABDBF dateStart: 20150223 customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn isFulltext: true dateEnd: 99991231 titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn omitProxy: true ssIdentifier: ssj0042033 providerName: EBSCOhost |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwvR1da9RAMNQWxBdRVPwsfXAfr-Zjk-w-Jnc5i6D40ELfSpJLLGJPsK3gPVUsbaH2Q5G2aLFFKkV86ItStP05Jm2f_AvOTHJ3qRS1CkJY5mZnZmdn9nZnwu5GUa5rEITHUq-VAt_iJW5FvBTYQVhSIwgveMhjX8XTyLfvWH0D_NagOdjRdbOwa2l8LOgNG0eeK_kbrwIO_IqnZI_h2ZZQQAAM_oUSPAzlH_mYeSYTZSYt5tlYSpt5VDqSAKiq5oBQkdjhzCEaR2XCJnabCYtoNCY4Yaok0EQWt9zEiENtCQ8YK5E__hiPEjJPMKfaZBckEEqNScJIaAs4vSqKE5WRJyFh4adDgIvaeJJUqaAqIF3qpC7QSASA0TGxCgGXaFTqSd4lF5Vy3WbLBpMeUYNEl_ihlpORBDIg4JC-kjl6rjiq6RUwwG4SO0fJrt0ySTGep1qQWaHaCkkABXTmVgvNgXUriERNwJatpZ-YPHJS5olyu0Zg8_CAQtJg7VszSb6LPsmadiuIQeULJDaa3lWpxmBCtoDiSx5dx7fW2Tls-luSfho-6FCz2YcyuvKIXtF4ANOghmi1u14_3rbcT17xiCRzebnpJ6fQYQONKXD2h_SA6eY_Nk5cGg1zcBw8OhLDEIFx_V_VsPH_J0wCVBqQx1ajsDjrpoGLs1WMJLKbTPMZUxTCApF9nqAZYWb39v8cvOD2NHBTOOL33u8N6xre-6LDfKfTd5hK9PGDdtTW2kvbGG48wCGDqZ84oXTpoJTeqXQ5bsWtFjIpaRZv-oSoH1KvdiZjmRBoFDIjGy8WbW84MDXDEkY7kzSFaXN605MFvVxXDdrM0zTLSYXlXbrxyw7RWcl67NfvFcL6_jPK6Twf73GyyfWs0tEYPqdMJc-X9paW0-UP6epaujqRbGym69PJ9FT6YjJZWEomdpOFFaSZn25Ngvtbk8nM1P7TV8niTPn77hxMc8na1-TN-sH0XDr_Mtn6kuy-T3c_phObIM7d25naf_Y23Z5Ntj_trWzsvZ48eDeZLM5DmX6e_bazDY2cVwaqXn-5r5R_sKY0ineklXjkW9LmUcQxkoLM2giEHgojijURRbEfBzw2LaMW-DyOpAq1thaGsW-GmHZDOnFB6aw_rEcXlR4ZqrEhLNWqRYKLIPClFWk1zVZrsR6qgXZJ6c7tNpQvSKNDh0bC5d8RXFFOtWeaq0rn2KPx6BokWGNBdz54fgC1TiQy |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E5%8C%96%E7%96%97%E6%97%A9%E6%9C%9F%E6%9C%80%E5%A4%A7%E6%A0%87%E5%87%86%E6%91%84%E5%8F%96%E5%80%BC%E5%8F%98%E5%8C%96%E7%8E%87Deauville%E8%AF%84%E5%88%86%E8%81%94%E5%90%88C%EF%BC%8Dmyc%E5%9F%BA%E5%9B%A0%E9%87%8D%E6%8E%92%E5%AF%B9%E5%BC%A5%E6%BC%AB%E6%80%A7%E5%A4%A7B%E7%BB%86%E8%83%9E%E6%B7%8B%E5%B7%B4%E7%98%A4%E7%9A%84%E9%A2%84%E5%90%8E%E9%A2%84%E6%B5%8B%E4%BB%B7%E5%80%BC&rft.jtitle=%E4%B8%AD%E5%8D%8E%E8%82%BF%E7%98%A4%E6%9D%82%E5%BF%97&rft.au=%E5%8E%9F%E5%87%8C&rft.au=%E8%B5%B5%E9%93%AD&rft.au=%E8%8B%8F%E4%B8%BD%E8%90%8D&rft.au=%E7%94%B0%E8%93%89%E8%93%89&rft.date=2022-08-23&rft.pub=%E5%B1%B1%E8%A5%BF%E7%9C%81%E8%82%BF%E7%98%A4%E5%8C%BB%E9%99%A2PET%2FCT%E5%AE%A4%EF%BC%8C%E5%A4%AA%E5%8E%9F%E3%80%80030013%25%E5%B1%B1%E8%A5%BF%E7%9C%81%E8%82%BF%E7%98%A4%E5%8C%BB%E9%99%A2%E8%A1%80%E6%B6%B2%E7%A7%91%EF%BC%8C%E5%A4%AA%E5%8E%9F%E3%80%80030013%25%E5%B1%B1%E8%A5%BF%E7%9C%81%E8%82%BF%E7%98%A4%E5%8C%BB%E9%99%A2%E7%97%85%E7%90%86%E7%A7%91%EF%BC%8C%E5%A4%AA%E5%8E%9F%E3%80%80030013&rft.issn=0253-3766&rft.volume=44&rft.issue=8&rft.spage=858&rft.epage=864&rft_id=info:doi/10.3760%2Fcma.j.cn112152-20200515-00452&rft.externalDocID=zhzl202208008 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzhzl%2Fzhzl.jpg |