鲍鱼壳对半水硫酸钙复合骨水泥的改性
R318.08; 半水硫酸钙复合骨水泥因其良好的可塑性和原位自固化性,在临床上有广泛的应用,但是其降解产物呈酸性不利于后续的骨组织再生.鲍鱼壳的主要成分是碳酸钙,可有效地调控骨水泥降解后微环境的pH.又因为其含有有机质因子和微量元素,大大提高了骨水泥的生物相容性.通过在骨水泥中加入鲍鱼壳,可注射性可提高到97.20％±0.28％,这主要是由于鲍鱼壳粉末的加入,影响了骨水泥的水化过程,延长了凝固时间(可达26.93 ±0.31 min).另一方面,鲍鱼壳粉末阻碍半水硫酸钙晶体长大,使得复合骨水泥中半水硫酸钙晶体变小(从1.42 ±0.77μm到0.90±0.36 μm),有效地缓解了复合骨水泥降...
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| Published in | 功能材料 Vol. 54; no. 11; pp. 11022 - 11029 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
天津大学材料科学与工程学院,天津 300350
30.11.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-9731 |
| DOI | 10.3969/j.issn.1001-9731.2023.11.004 |
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| Abstract | R318.08; 半水硫酸钙复合骨水泥因其良好的可塑性和原位自固化性,在临床上有广泛的应用,但是其降解产物呈酸性不利于后续的骨组织再生.鲍鱼壳的主要成分是碳酸钙,可有效地调控骨水泥降解后微环境的pH.又因为其含有有机质因子和微量元素,大大提高了骨水泥的生物相容性.通过在骨水泥中加入鲍鱼壳,可注射性可提高到97.20％±0.28％,这主要是由于鲍鱼壳粉末的加入,影响了骨水泥的水化过程,延长了凝固时间(可达26.93 ±0.31 min).另一方面,鲍鱼壳粉末阻碍半水硫酸钙晶体长大,使得复合骨水泥中半水硫酸钙晶体变小(从1.42 ±0.77μm到0.90±0.36 μm),有效地缓解了复合骨水泥降解过程中pH的下降(从6.08±0.06到6.93±0.02),极大地提高了细胞存活率(从87.00％±1.60％到96.41％±1.44％).因此,研究表明鲍鱼壳的加入在临床上是一种潜在地提高骨水泥生物相容性的有效手段. |
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| AbstractList | R318.08; 半水硫酸钙复合骨水泥因其良好的可塑性和原位自固化性,在临床上有广泛的应用,但是其降解产物呈酸性不利于后续的骨组织再生.鲍鱼壳的主要成分是碳酸钙,可有效地调控骨水泥降解后微环境的pH.又因为其含有有机质因子和微量元素,大大提高了骨水泥的生物相容性.通过在骨水泥中加入鲍鱼壳,可注射性可提高到97.20％±0.28％,这主要是由于鲍鱼壳粉末的加入,影响了骨水泥的水化过程,延长了凝固时间(可达26.93 ±0.31 min).另一方面,鲍鱼壳粉末阻碍半水硫酸钙晶体长大,使得复合骨水泥中半水硫酸钙晶体变小(从1.42 ±0.77μm到0.90±0.36 μm),有效地缓解了复合骨水泥降解过程中pH的下降(从6.08±0.06到6.93±0.02),极大地提高了细胞存活率(从87.00％±1.60％到96.41％±1.44％).因此,研究表明鲍鱼壳的加入在临床上是一种潜在地提高骨水泥生物相容性的有效手段. |
| Author | 刘菁宇 李朝阳 梁砚琴 朱胜利 姜辉 吴水林 |
| AuthorAffiliation | 天津大学材料科学与工程学院,天津 300350 |
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| Author_FL | ZHU Shengli LI Zhaoyang LIU Jingyu JIANG Hui LIANG Yanqin WU Shuilin |
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| Keywords | bone cement hydroxyapatite calcium sulfate hemihydrate 羟基磷灰石 半水硫酸钙 abalone shell 鲍鱼壳 骨水泥 |
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| Snippet | R318.08; 半水硫酸钙复合骨水泥因其良好的可塑性和原位自固化性,在临床上有广泛的应用,但是其降解产物呈酸性不利于后续的骨组织再生.鲍鱼壳的主要成分是碳酸钙,可有效地调... |
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| Title | 鲍鱼壳对半水硫酸钙复合骨水泥的改性 |
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