促性腺激素释放激素类似物在乳腺癌治疗中的应用及前景
促性腺激素释放激素类似物(GnRHa)在绝经前乳腺癌患者中的应用日益广泛,因其可抑制卵泡刺激素和黄体生成素的分泌,使绝经前女性体内雌激素达到绝经后水平. GnRHa可抑制与雌激素相关的肿瘤生长,作用与手术去势或化疗相当;同时可保护卵巢功能,防止卵巢早衰;GnRHa可降低乳腺密度、子宫内膜厚度,在预防乳腺癌高危人群及提高乳腺癌患者生存质量方面具有潜在价值....
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| Published in | 中华肿瘤杂志 Vol. 41; no. 4; pp. 246 - 250 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
上海交通大学附属上海市第六人民医院乳腺外科 200233%浙江省肿瘤医院乳腺外科,杭州,310022
01.04.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-3766 |
| DOI | 10.3760/cma.j.issn.0253-3766.2019.04.002 |
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| Abstract | 促性腺激素释放激素类似物(GnRHa)在绝经前乳腺癌患者中的应用日益广泛,因其可抑制卵泡刺激素和黄体生成素的分泌,使绝经前女性体内雌激素达到绝经后水平. GnRHa可抑制与雌激素相关的肿瘤生长,作用与手术去势或化疗相当;同时可保护卵巢功能,防止卵巢早衰;GnRHa可降低乳腺密度、子宫内膜厚度,在预防乳腺癌高危人群及提高乳腺癌患者生存质量方面具有潜在价值. |
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| AbstractList | 促性腺激素释放激素类似物(GnRHa)在绝经前乳腺癌患者中的应用日益广泛,因其可抑制卵泡刺激素和黄体生成素的分泌,使绝经前女性体内雌激素达到绝经后水平. GnRHa可抑制与雌激素相关的肿瘤生长,作用与手术去势或化疗相当;同时可保护卵巢功能,防止卵巢早衰;GnRHa可降低乳腺密度、子宫内膜厚度,在预防乳腺癌高危人群及提高乳腺癌患者生存质量方面具有潜在价值. |
| Abstract_FL | Gonadotropin?releasing?hormone analogues (GnRHa) are widely used in the treatment of premenopausal breast cancer. The anti?tumor effect of GnRHa is similar to that of surgical castration or chemotherapy, through reversibly inhibiting ovarian function and downregulating the estrogen level in premenopausal female. At the same time, GnRHa can protect the ovarian function, avoiding premature ovarian failure. Also GnRHa can reduce the breast density and endometrial thickness, as a result of which GnRHa may be used to prevent breast cancer in the higher risk population and promote quality of life in breast cancer patients. We here review the clinical roles and research progress of GnRHa in breast cancer. |
| Author | 宗祥云 李晓林 俞洋 |
| AuthorAffiliation | 上海交通大学附属上海市第六人民医院乳腺外科 200233%浙江省肿瘤医院乳腺外科,杭州,310022 |
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| Author_FL | Yu Yang Zong Xiangyun Li Xiaolin |
| Author_FL_xml | – sequence: 1 fullname: Li Xiaolin – sequence: 2 fullname: Yu Yang – sequence: 3 fullname: Zong Xiangyun |
| Author_xml | – sequence: 1 fullname: 李晓林 – sequence: 2 fullname: 俞洋 – sequence: 3 fullname: 宗祥云 |
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| DocumentTitle_FL | Summary and expectation of the role of GnRHa in the treatment of breast cancer |
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| Keywords | 卵巢功能 Breast density Ovarian function 促性腺激素释放激素类似物 [Subject words] Breast neoplasms [主题词] 乳腺肿瘤 Adjuvant endocrine therapy 乳腺密度 辅助内分泌治疗 GnRHa |
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| Publisher | 上海交通大学附属上海市第六人民医院乳腺外科 200233%浙江省肿瘤医院乳腺外科,杭州,310022 |
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| Title | 促性腺激素释放激素类似物在乳腺癌治疗中的应用及前景 |
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