巴戟天中环烯醚萜苷和蒽醌在电喷雾离子源负离子模式下的质谱裂解行为
O657.63; 利用电喷雾-四极杆-飞行时间串联质谱(ESI-Q-TOF MS/MS)技术,在负离子模式下,探讨巴戟天中4种环烯醚萜苷和2种蒽醌成分的质谱裂解途径.通过[M-H]-获得化合物的相对分子质量信息,进一步对[M-H]-进行碰撞诱导解离,获得相应化合物的裂解途径.结果表明,环烯醚萜苷主要的裂解途径是首先脱去母环上的功能基团,如中性丢失 H2O、CO2、CH3COOH 和糖单元等部分;其次是二氢吡喃环和糖环的断裂,m/z 113、101为环烯醚萜苷母环断裂的特征碎片离子.蒽醌类化合物的裂解行为是连续失去CO,也可以失去CO2.这些质谱裂解行为的研究有助于环烯醚萜苷和蒽醌类化合物的结构...
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| Published in | 质谱学报 Vol. 39; no. 3; pp. 342 - 350 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
中国医学科学院药用植物研究所海南分所,海南 海口,571100%中国医学科学院药用植物研究所,北京,100193%西南科技大学生命科学与工程学院,四川 绵阳,621010
01.05.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1004-2997 |
| DOI | 10.7538/zpxb.2017.0100 |
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| Abstract | O657.63; 利用电喷雾-四极杆-飞行时间串联质谱(ESI-Q-TOF MS/MS)技术,在负离子模式下,探讨巴戟天中4种环烯醚萜苷和2种蒽醌成分的质谱裂解途径.通过[M-H]-获得化合物的相对分子质量信息,进一步对[M-H]-进行碰撞诱导解离,获得相应化合物的裂解途径.结果表明,环烯醚萜苷主要的裂解途径是首先脱去母环上的功能基团,如中性丢失 H2O、CO2、CH3COOH 和糖单元等部分;其次是二氢吡喃环和糖环的断裂,m/z 113、101为环烯醚萜苷母环断裂的特征碎片离子.蒽醌类化合物的裂解行为是连续失去CO,也可以失去CO2.这些质谱裂解行为的研究有助于环烯醚萜苷和蒽醌类化合物的结构解析,也可为其他同类化合物的鉴定提供依据. |
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| AbstractList | O657.63; 利用电喷雾-四极杆-飞行时间串联质谱(ESI-Q-TOF MS/MS)技术,在负离子模式下,探讨巴戟天中4种环烯醚萜苷和2种蒽醌成分的质谱裂解途径.通过[M-H]-获得化合物的相对分子质量信息,进一步对[M-H]-进行碰撞诱导解离,获得相应化合物的裂解途径.结果表明,环烯醚萜苷主要的裂解途径是首先脱去母环上的功能基团,如中性丢失 H2O、CO2、CH3COOH 和糖单元等部分;其次是二氢吡喃环和糖环的断裂,m/z 113、101为环烯醚萜苷母环断裂的特征碎片离子.蒽醌类化合物的裂解行为是连续失去CO,也可以失去CO2.这些质谱裂解行为的研究有助于环烯醚萜苷和蒽醌类化合物的结构解析,也可为其他同类化合物的鉴定提供依据. |
| Abstract_FL | Morinda officinalis,the dried root of Morinda officinalis How,is com-monly used as a traditional Chinese medicine for the treatment of impotence and osteo-porosis in clinical theraphy,and this effect is supposed to be attributed to iridoid glyco-side and anthraquinone compounds.Recent years,liquid chromatography coupled with high resolution mass spectrometry was widely used for the identification of components from traditional Chinese medicine based on the fragmentation pathways of main compo-nents.However,reports on the fragmentation pathway of main ingredients in M.offi-cinalis were limited.Therefore,in this paper,the fragmentation pathways of 4 iridoid glycosides (monotropein,deacetyla sperulosidic acid,asperulosidic acid and asperulo-side)and 2 anthraquinones (rubiadin-1-methyl ether and rubiadin)in M.officinalis were investigated using electrospray ionization quadrupole time-of-flight tandem mass spectrometry (ESI-Q-TOF MS/MS)in negative ion mode.The deprotonated [M-H]-were observed by ESI-MS,from which the molecular weights were deduced.The colli-sion induced dissociation (CID)data of [M-H]- ions provided fragmentation informa-tion of the compounds of interest.The main and typical fragmentation pathway of iri-doid glycosides were neutral losses of H2O,CO2,CH3COOH and glucosidic units. Meanwhile,the cleavages of dihydropyranoid and sugar ring were also observed.The common fragment ions of m/z 1 1 3,1 0 1 were the characteristic ions for the cleavages of dihydropyranoid.The fragmentation process of anthraquinones was continual loss of CO followed by dissociation of CO2.The experimental results indicated that the fragmenta-tion behavior of iridoid glycosides and anthraquinones was reasonable and could provide the basis for their structures elucidation and identification. |
| Author | 舒晓燕 杨美华 吴海峰 赵祥升 |
| AuthorAffiliation | 中国医学科学院药用植物研究所海南分所,海南 海口,571100%中国医学科学院药用植物研究所,北京,100193%西南科技大学生命科学与工程学院,四川 绵阳,621010 |
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| Author_FL | SHU Xiao-yan YANG Mei-hua WU Hai-feng ZHAO Xiang-sheng |
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| DocumentTitle_FL | Fragmentation Behavior for Iridoid Glucosides and Anthraquinones in Morinda of ficinalis by ESI-Q-TOF MS/MS in Negative Ion Mode |
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| Keywords | electrospray ionization quadrupole time-of-flight tan-dem mass spectrometry (ESI-Q-TOF MS/MS) 巴戟天 fragmentation behavior 电喷雾-四极杆-飞行时间串联质谱(ESI-Q-TOFMS/MS) anthraquinones 裂解行为 Morinda officinalis iridoid glucosides 环烯醚萜苷 蒽醌 |
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| Title | 巴戟天中环烯醚萜苷和蒽醌在电喷雾离子源负离子模式下的质谱裂解行为 |
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