黄体酮增溶制剂技术研究进展

R943; 黄体酮是目前临床上治疗、预防先兆流产和习惯性流产的一线药物,但由于具有特殊的化学结构,导致其溶解度低,限制了其在临床的应用.因此,黄体酮增溶制剂新技术和新剂型是其研究开发的重要方向.本文对近年来黄体酮增溶制剂技术的研究进展进行了综述,发现可通过固体分散体技术、包合技术、微粉化、纳米化(包括纳米混悬剂、聚合物胶束、纳米粒等)、脂质体技术、自乳化、共晶技术、3D打印这8项技术来增大黄体酮的溶解度,提高其生物利用度,减少其毒副作用,从而更好地服务于临床....

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Published in中国药房 Vol. 35; no. 21; pp. 2703 - 2708
Main Authors 江婷婷, 汪云云, 武香香, 曾华辉, 朱鑫
Format Journal Article
LanguageChinese
Published 河南中医药大学药学院,郑州 450018%河南中医药大学中医药科学院,郑州 450018 2024
Subjects
黄体酮
增溶技术
preparation method
bioavailability
progesterone
solubility-enhancing formulation technology
溶解度
solubility
生物利用度
制剂技术
Online AccessGet full text
ISSN1001-0408
DOI10.6039/j.issn.1001-0408.2024.21.21

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Abstract R943; 黄体酮是目前临床上治疗、预防先兆流产和习惯性流产的一线药物,但由于具有特殊的化学结构,导致其溶解度低,限制了其在临床的应用.因此,黄体酮增溶制剂新技术和新剂型是其研究开发的重要方向.本文对近年来黄体酮增溶制剂技术的研究进展进行了综述,发现可通过固体分散体技术、包合技术、微粉化、纳米化(包括纳米混悬剂、聚合物胶束、纳米粒等)、脂质体技术、自乳化、共晶技术、3D打印这8项技术来增大黄体酮的溶解度,提高其生物利用度,减少其毒副作用,从而更好地服务于临床.
AbstractList R943; 黄体酮是目前临床上治疗、预防先兆流产和习惯性流产的一线药物,但由于具有特殊的化学结构,导致其溶解度低,限制了其在临床的应用.因此,黄体酮增溶制剂新技术和新剂型是其研究开发的重要方向.本文对近年来黄体酮增溶制剂技术的研究进展进行了综述,发现可通过固体分散体技术、包合技术、微粉化、纳米化(包括纳米混悬剂、聚合物胶束、纳米粒等)、脂质体技术、自乳化、共晶技术、3D打印这8项技术来增大黄体酮的溶解度,提高其生物利用度,减少其毒副作用,从而更好地服务于临床.
Abstract_FL Progesterone is currently the first-line drug for clinical treatment and prevention of threatened abortion and habitual abortion.However,due to its special chemical structure,its solubility is low,which limits its clinical application.Therefore,the new technology and new dosage form of progesterone solubilization preparation is an important direction of its research and development.In this paper,the research progress of progesterone solubilization preparation technology in recent years is reviewed.It is found that the water solubility of progesterone can be enhanced by solid dispersion technology,inclusion technology,micronization,nanocrystallization(including nanosuspensions,polymer micelles,nanoparticles,etc.),liposome technology,self-emulsification,cocrystal technology,and 3D printing.Eight technologies are used to increase the solubility of progesterone,improve its bioavailability and reduce its toxic and side effects,to serve the clinic better.
Author 武香香
汪云云
曾华辉
江婷婷
朱鑫
AuthorAffiliation 河南中医药大学药学院,郑州 450018%河南中医药大学中医药科学院,郑州 450018
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Author_FL Wang Yunyun
Zhu Xin
ZENG Huahui
JIANG Tingting
Wu Xiangxiang
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DocumentTitle_FL Research advances in solubility-enhancing formulation technologies for progesterone
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Issue 21
Keywords 黄体酮
增溶技术
preparation method
bioavailability
progesterone
solubility-enhancing formulation technology
溶解度
solubility
生物利用度
制剂技术
Language Chinese
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PublicationYear 2024
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Snippet R943; 黄体酮是目前临床上治疗、预防先兆流产和习惯性流产的一线药物,但由于具有特殊的化学结构,导致其溶解度低,限制了其在临床的应用.因此,黄体酮增溶制剂新技术和新剂型...
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