A pharmacogenomic study on the pharmacokinetics of tacrolimus in healthy subjects using the DMET TM Plus platform - Choi, Y; Jiang, F; An, H; Park, H J; Choi, J H; Lee, H (The pharmacogenomics journal, 2017)
Keywords: Adult; Area Under Curve; Calcineurin Inhibitors - administration & dosage; Calcineurin Inhibitors - blood; Calcineurin Inhibitors - pharmacokinetics; Cross-Over Studies; Cytochrome P-450 CYP3A - genetics; Cytochrome P-450 CYP3A - metabolism; Double-Blind Method; Gene Expression Profiling - methods; Genotype; HCT116 Cells; Healthy Volunteers; HEK293 Cells; Hep G2 Cells; Humans; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - blood; Immunosuppressive Agents - pharmacokinetics; Male; Oligonucleotide Array Sequence Analysis; Pharmacogenetics; Pharmacogenomic Testing - methods; Pharmacogenomic Variants; Phenotype; Polymorphism, Single Nucleotide; Predictive Value of Tests; Pregnane X Receptor; Receptors, Steroid - genetics; Receptors, Steroid - metabolism; Seoul; Tacrolimus - administration & dosage; Tacrolimus - blood; Tacrolimus - pharmacokinetics; Transfection; Young Adult