视神经脊髓炎谱系疾病、系统性红斑狼疮和胸腺瘤共病一例
R593.2; 一例53岁男性患者,因"右眼视力下降2个月,伴双下肢无力8 d"入院.胸椎增强MRI提示胸髓T3水平偏右侧信号异常,考虑脱髓鞘病变,血清水通道蛋白质4抗体阳性,效价为1:320,诊断为视神经脊髓炎谱系疾病.该患者同时合并系统性红斑狼疮和胸腺瘤.经甲泼尼龙冲击、血浆置换、免疫抑制剂等治疗后,患者右眼视力及双下肢无力逐渐好转....
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| Published in | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban Vol. 47; no. 1; pp. 71 - 74 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Chinese English |
| Published |
温岭市第一人民医院神经内科,浙江 台州,317500%浙江大学医学院附属邵逸夫医院神经内科,浙江 杭州,310016
25.02.2018
Beijing Zhongke Journal Publising Co. Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-9292 |
| DOI | 10.3785/j.issn.1008-9292.2018.02.10 |
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| Abstract | R593.2; 一例53岁男性患者,因"右眼视力下降2个月,伴双下肢无力8 d"入院.胸椎增强MRI提示胸髓T3水平偏右侧信号异常,考虑脱髓鞘病变,血清水通道蛋白质4抗体阳性,效价为1:320,诊断为视神经脊髓炎谱系疾病.该患者同时合并系统性红斑狼疮和胸腺瘤.经甲泼尼龙冲击、血浆置换、免疫抑制剂等治疗后,患者右眼视力及双下肢无力逐渐好转. |
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| AbstractList | 一例53岁男性患者，因“右眼视力下降2个月，伴双下肢无力8 d”入院。胸椎增强MRI提示胸髓T3水平偏右侧信号异常，考虑脱髓鞘病变，血清水通道蛋白质4抗体阳性，效价为1:320，诊断为视神经脊髓炎谱系疾病。该患者同时合并系统性红斑狼疮和胸腺瘤。经甲泼尼龙冲击、血浆置换、免疫抑制剂等治疗后，患者右眼视力及双下肢无力逐渐好转。 R593.2; 一例53岁男性患者,因"右眼视力下降2个月,伴双下肢无力8 d"入院.胸椎增强MRI提示胸髓T3水平偏右侧信号异常,考虑脱髓鞘病变,血清水通道蛋白质4抗体阳性,效价为1:320,诊断为视神经脊髓炎谱系疾病.该患者同时合并系统性红斑狼疮和胸腺瘤.经甲泼尼龙冲击、血浆置换、免疫抑制剂等治疗后,患者右眼视力及双下肢无力逐渐好转. |
| Abstract_FL | A 53-year-old male patient presented with hypopsia of his right eye for 2 months and lower extremities weakness for 8 days. Thoracic MRI demonstrated a lesion at T3 level appearing as hyperintense on T2-weighted images with non-enhancement by contrast medium and demyelinating lesion was considered. Aquaporin-4-Ab was positive and the antibody titer was 1: 320 in serum. The diagnosis of neuromyelitis optica spectrum disorders was made. In addition, systemic lupus erythematosus and thymoma coexisted in this patient. After methylprednisolone impacttreatment, plasma exchange and immunosuppressive therapy, the right vision and lower extremities weakness of the patient were improved. |
| Author | 周海金 夏萍 胡兴越 |
| AuthorAffiliation | 温岭市第一人民医院神经内科,浙江 台州,317500%浙江大学医学院附属邵逸夫医院神经内科,浙江 杭州,310016 |
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| Author_FL | XIA Ping ZHOU Haijin HU Xingyue |
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| ClassificationCodes | R593.2 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. The Author(s) 2021. 版权所有©《浙江大学学报(医学版)》编辑部2018 Copyright ©2018 Journal of Zhejiang University(Medical Sciences). All rights reserved. 2018 |
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| DocumentTitle_FL | A case of neuromyelitis optica spectrum disorders complicated with systemic lupus erythematosus and thymoma |
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| Keywords | 红斑狼疮,系统性/治疗 Aquaporin 4 神经系统自身免疫疾病/治疗 Autoimmune diseases of the nervous system/therapy Lupus erythematosus,systemic/therapy 视神经脊髓炎/诊断 Case reports 红斑狼疮,系统性/诊断 水通道蛋白质4 病例报告 Thymoma/therapy Lupus erythematosus systemic/diagnosis 胸腺瘤/治疗 Neuromyelitis optica/diagnosis |
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| Notes | zhouhaijinabc@126.com https://orcid.org/0000-0002-3458-0803第一作者：周海金(1983-), 男, 硕士, 主治医师, 主要从事神经病学研究; E-mail |
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| PublicationTitle | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban |
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| PublicationYear | 2018 |
| Publisher | 温岭市第一人民医院神经内科,浙江 台州,317500%浙江大学医学院附属邵逸夫医院神经内科,浙江 杭州,310016 Beijing Zhongke Journal Publising Co. Ltd |
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| Snippet | R593.2; 一例53岁男性患者,因"右眼视力下降2个月,伴双下肢无力8 d"入院.胸椎增强MRI提示胸髓T3水平偏右侧信号异常,考虑脱髓鞘病变,血清水通道蛋白质4抗体阳性,效价... 一例53岁男性患者，因“右眼视力下降2个月，伴双下肢无力8 d”入院。胸椎增强MRI提示胸髓T3水平偏右侧信号异常，考虑脱髓鞘病变，血清水通道蛋白质4抗体阳性，效价为1:320，... |
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| Title | 视神经脊髓炎谱系疾病、系统性红斑狼疮和胸腺瘤共病一例 |
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