多灶性磨玻璃影肺腺癌的临床及分子特征

随着人们对肺癌早期筛查的重视,肺多发磨玻璃影(multiple ground glass opacities, GGOs)的检出率逐年增高,以GGOs为表现的多灶肺腺癌也逐渐成为临床研究热点.其更多见于女性、非吸烟者,且无论是自然病程还是手术后的患者均有极佳预后.独特的临床特征提示其很可能是相对独立的一种疾病形式.从分子遗传学路径对其的探究发现,同一个体内的多个病灶间极可能有截然不同的克隆性特征,因此遗传异质性(genetic heterogeneity)是以GGOs为表现多灶肺腺癌最显著的分子遗传学特征.此特征可辅助原发多灶肺腺癌与肺癌肺内转移的鉴别诊断,也提示了对病灶进行分子遗传学检测的治...

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Published inZhongguo fei ai za zhi Vol. 21; no. 3; pp. 163 - 167
Main Authors 宋洋, 梁乃新, 李单青
Format Journal Article
LanguageChinese
English
Published 天津市和平区南京路228号300020 100084 北京,清华大学医学院%中国医学科学院北京协和医学院北京协和医院胸外科,0 北京,110073 20.03.2018
1100730 北京,中国医学科学院北京协和医学院北京协和医院胸外科
中国肺癌杂志编辑部
Subjects
Expert Opinion
特约专题
Multiple primary lung cancer
多原发肺癌
遗传异质性
气腔播散转移
Spread through air spaces (STAS)
Genetic heterogeneity
EGFR
Online AccessGet full text
ISSN1009-3419
1999-6187
DOI10.3779/j.issn.1009-3419.2018.03.07

Cover

Abstract 随着人们对肺癌早期筛查的重视,肺多发磨玻璃影(multiple ground glass opacities, GGOs)的检出率逐年增高,以GGOs为表现的多灶肺腺癌也逐渐成为临床研究热点.其更多见于女性、非吸烟者,且无论是自然病程还是手术后的患者均有极佳预后.独特的临床特征提示其很可能是相对独立的一种疾病形式.从分子遗传学路径对其的探究发现,同一个体内的多个病灶间极可能有截然不同的克隆性特征,因此遗传异质性(genetic heterogeneity)是以GGOs为表现多灶肺腺癌最显著的分子遗传学特征.此特征可辅助原发多灶肺腺癌与肺癌肺内转移的鉴别诊断,也提示了对病灶进行分子遗传学检测的治疗意义.部分呈现出遗传相似性的GGOs病灶为气腔播散转移(spread through air spaces, STAS)理论提供了新的证据.
AbstractList 随着人们对肺癌早期筛查的重视,肺多发磨玻璃影(multiple ground glass opacities, GGOs)的检出率逐年增高,以GGOs为表现的多灶肺腺癌也逐渐成为临床研究热点.其更多见于女性、非吸烟者,且无论是自然病程还是手术后的患者均有极佳预后.独特的临床特征提示其很可能是相对独立的一种疾病形式.从分子遗传学路径对其的探究发现,同一个体内的多个病灶间极可能有截然不同的克隆性特征,因此遗传异质性(genetic heterogeneity)是以GGOs为表现多灶肺腺癌最显著的分子遗传学特征.此特征可辅助原发多灶肺腺癌与肺癌肺内转移的鉴别诊断,也提示了对病灶进行分子遗传学检测的治疗意义.部分呈现出遗传相似性的GGOs病灶为气腔播散转移(spread through air spaces, STAS)理论提供了新的证据.
随着人们对肺癌早期筛查的重视，肺多发磨玻璃影（multiple ground glass opacities, GGOs）的检出率逐年增高，以GGOs为表现的多灶肺腺癌也逐渐成为临床研究热点。其更多见于女性、非吸烟者，且无论是自然病程还是手术后的患者均有极佳预后。独特的临床特征提示其很可能是相对独立的一种疾病形式。从分子遗传学路径对其的探究发现，同一个体内的多个病灶间极可能有截然不同的克隆性特征，因此遗传异质性（genetic heterogeneity）是以GGOs为表现多灶肺腺癌最显著的分子遗传学特征。此特征可辅助原发多灶肺腺癌与肺癌肺内转移的鉴别诊断，也提示了对病灶进行分子遗传学检测的治疗意义。部分呈现出遗传相似性的GGOs病灶为气腔播散转移（spread through air spaces, STAS）理论提供了新的证据。
Abstract_FL Due to emphasis on early screening for lung cancer, the detection rate of multiple ground glass opacities (GGOs) on computed tomography (CT) image increases in recent years, and research on multifocal adeno-carcinomas presented by GGOs has been thriving. It is more common in women and non-smokers and has excellent prognosis both in patients with natural history and after surgery. These clinical features suggest that it is likely to be a distinct disease entity. From the perspective of molecular genetics, lesions in the same individual are likely to have dis-tinct clonal features. Therefore, genetic heterogeneity is the most prominent feature of multifocal pulmonary adenocar-cinomas with GGOs. The genetic heterogeneity is expected to assist the diagnosis of multifocal pulmonary adenocarci-noma and intrapulmonary metastasis, and also suggests that genetic testing of the GGO lesions is of great therapeutic significance. Some GGO lesions may harvest the similar clonal feature, which provide new evidence for the theory of spread through air spaces (STAS).
Author 梁乃新
李单青
宋洋
AuthorAffiliation 1100730 北京,中国医学科学院北京协和医学院北京协和医院胸外科;100084 北京,清华大学医学院%中国医学科学院北京协和医学院北京协和医院胸外科,0 北京,110073
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Author_FL Naixin LIANG
Yang SONG
Shanqing LI
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版权所有©《中国肺癌杂志》编辑部2018 Copyright ©2018 Chinese Journal of Lung Cancer. All rights reserved. 2018
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DocumentTitle_FL The Clinical and Molecular Characteristics of Adenocarcinoma Presented by Multi-focal GGO
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Keywords Multiple primary lung cancer
多原发肺癌
遗传异质性
气腔播散转移
Spread through air spaces (STAS)
Genetic heterogeneity
EGFR
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English
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PublicationTitle Zhongguo fei ai za zhi
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Snippet 随着人们对肺癌早期筛查的重视,肺多发磨玻璃影(multiple ground glass opacities, GGOs)的检出率逐年增高,以GGOs为表现的多灶肺腺癌也逐渐成为临床研究热点.其更多见于女...
随着人们对肺癌早期筛查的重视，肺多发磨玻璃影（multiple ground glass opacities, GGOs）的检出率逐年增高，以GGOs为表现的多灶肺腺癌也逐渐成为临床研究热点。其更多见...
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StartPage 163
SubjectTerms Expert Opinion
特约专题
Title 多灶性磨玻璃影肺腺癌的临床及分子特征
URI https://d.wanfangdata.com.cn/periodical/zgfazz201803007
https://pubmed.ncbi.nlm.nih.gov/PMC5973028
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