重视潜质未定的克隆性造血和意义未定的克隆性血细胞减少症的诊断和治疗
2022年提出的造血淋巴肿瘤WHO分型（WHO 2022）以及髓系肿瘤和急性白血病国际共识分型（ICC）已将潜质未定的克隆性造血（CHIP）和意义未定的克隆性血细胞减少症（CCUS）正式列入了髓系肿瘤分型。最近又相继提出了三个CHIP和CCUS髓系肿瘤转化分险的预测模型，并已开展了CHIP和CCUS干预治疗临床试验。为了规范CHIP和CCUS的诊断和治疗，本文就目前我国面临的挑战以及可能的解决方案做了探讨。...
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| Published in | Zhōnghuá xuèyèxué zázhì Vol. 46; no. 1; pp. 5 - 8 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese English |
| Published |
No. 288, Nanjing road, Heping district, Tianjin
中国医学科学院血液病医院（中国医学科学院血液学研究所），血液与健康全国重点实验室，国家血液系统疾病临床医学研究中心，细胞生态海河实验室，天津 300020%天津医学健康研究院，天津 301600
2025
Editorial office of Chinese Journal of Hematology |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-2727 2707-9740 |
| DOI | 10.3760/cma.j.cn121090-20241228-00600 |
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| Abstract | 2022年提出的造血淋巴肿瘤WHO分型（WHO 2022）以及髓系肿瘤和急性白血病国际共识分型（ICC）已将潜质未定的克隆性造血（CHIP）和意义未定的克隆性血细胞减少症（CCUS）正式列入了髓系肿瘤分型。最近又相继提出了三个CHIP和CCUS髓系肿瘤转化分险的预测模型，并已开展了CHIP和CCUS干预治疗临床试验。为了规范CHIP和CCUS的诊断和治疗，本文就目前我国面临的挑战以及可能的解决方案做了探讨。 |
|---|---|
| AbstractList | 2022年提出的造血淋巴肿瘤WHO分型（WHO 2022）以及髓系肿瘤和急性白血病国际共识分型（ICC）已将潜质未定的克隆性造血（CHIP）和意义未定的克隆性血细胞减少症（CCUS）正式列入了髓系肿瘤分型。最近又相继提出了三个CHIP和CCUS髓系肿瘤转化分险的预测模型，并已开展了CHIP和CCUS干预治疗临床试验。为了规范CHIP和CCUS的诊断和治疗，本文就目前我国面临的挑战以及可能的解决方案做了探讨。 |
| Abstract_FL | Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenias of undetermined significance (CCUS) are included in both fifth edition of the World Health Organization classification (WHO 2022) and International Consensus Classification (ICC). Recently three models were developed for prediction of myeloid neoplasms risk and clinical trials are initiated to investigate potential treatments for CHIP and CCUS. Challenges in diagnosis and therapeutic intervention of CHIP and CCUS were discussed. |
| Author | 肖志坚 |
| AuthorAffiliation | 中国医学科学院血液病医院（中国医学科学院血液学研究所），血液与健康全国重点实验室，国家血液系统疾病临床医学研究中心，细胞生态海河实验室，天津 300020%天津医学健康研究院，天津 301600 |
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| Author_FL | Xiao Zhijian |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. 2025年版权归中华医学会所有 Copyright © 2025 by Chinese Medical Association 2025 |
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| Keywords | 治疗 Clonal cytopenias of undetermined significance 潜质未定的克隆性造血 诊断 Clonal hematopoiesis of indeterminate potential Treatment 克隆性造血 Clonal hematopoiesis Diagnosis 意义未定的克隆性血细胞减少症 |
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| Title | 重视潜质未定的克隆性造血和意义未定的克隆性血细胞减少症的诊断和治疗 |
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