内镜结扎联合中医辨证论治对肝硬化食管静脉曲张破裂出血的二级预防效果
目的 观察内镜下结扎联合中医辨证论治防治肝硬化食管静脉曲张破裂出血(EVB)二级预防的疗效。 方法 选取2015年4月—2021年2月上海中医药大学附属曙光医院肝硬化科收治的行内镜下结扎治疗的EVB患者108例，对同时服用中药治疗的患者定义为中西医组(n=59)，对未服用中药治疗的患者定义西医组(n=49)。比较两组患者的再出血发生率、病死率以及门静脉高压性胃病的改善率等。计量资料符合正态分布者采用t检验；不符合正态分布者采用Mann-Whitney U秩和检验；计数资料2组间对比采用χ2检验或Fisher确切概率法；并采用Cox回归分析评估影响再出血的危险因素。 结果 中西医组内镜结扎后13...
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| Published in | Linchuang gandanbing zazhi Vol. 38; no. 5; pp. 1075 - 1080 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.01.2022
上海中医药大学附属曙光医院,上海市中医药研究院肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2022.05.019 |
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| Abstract | 目的 观察内镜下结扎联合中医辨证论治防治肝硬化食管静脉曲张破裂出血(EVB)二级预防的疗效。 方法 选取2015年4月—2021年2月上海中医药大学附属曙光医院肝硬化科收治的行内镜下结扎治疗的EVB患者108例，对同时服用中药治疗的患者定义为中西医组(n=59)，对未服用中药治疗的患者定义西医组(n=49)。比较两组患者的再出血发生率、病死率以及门静脉高压性胃病的改善率等。计量资料符合正态分布者采用t检验；不符合正态分布者采用Mann-Whitney U秩和检验；计数资料2组间对比采用χ2检验或Fisher确切概率法；并采用Cox回归分析评估影响再出血的危险因素。 结果 中西医组内镜结扎后13~24个月的再出血率显著低于西医组(2% vs 12%, P=0.045)；中西医组再出血病死率显著低于西医组(2% vs 12%, P=0.045)，且门静脉高压性胃病的总有效率显著高于西医组(90% vs 77%, P=0.04)。基础疾病(主要包括糖尿病、高血压、心脏病)及肝功能Child-Pugh分级是影响再出血的显著危险因素(P值均＜0.05)。 结论 内镜结扎联合中医辨证论治可显著降低EVB的迟发性再出血发生率和病死率，改善门静脉高压性胃病的程度，为结扎联合中医药提高EVB二级预防的综合疗效提供了新策略。 |
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| AbstractList | 目的 观察内镜下结扎联合中医辨证论治防治肝硬化食管静脉曲张破裂出血(EVB)二级预防的疗效。 方法 选取2015年4月—2021年2月上海中医药大学附属曙光医院肝硬化科收治的行内镜下结扎治疗的EVB患者108例，对同时服用中药治疗的患者定义为中西医组(n=59)，对未服用中药治疗的患者定义西医组(n=49)。比较两组患者的再出血发生率、病死率以及门静脉高压性胃病的改善率等。计量资料符合正态分布者采用t检验；不符合正态分布者采用Mann-Whitney U秩和检验；计数资料2组间对比采用χ2检验或Fisher确切概率法；并采用Cox回归分析评估影响再出血的危险因素。 结果 中西医组内镜结扎后13~24个月的再出血率显著低于西医组(2% vs 12%, P=0.045)；中西医组再出血病死率显著低于西医组(2% vs 12%, P=0.045)，且门静脉高压性胃病的总有效率显著高于西医组(90% vs 77%, P=0.04)。基础疾病(主要包括糖尿病、高血压、心脏病)及肝功能Child-Pugh分级是影响再出血的显著危险因素(P值均＜0.05)。 结论 内镜结扎联合中医辨证论治可显著降低EVB的迟发性再出血发生率和病死率，改善门静脉高压性胃病的程度，为结扎联合中医药提高EVB二级预防的综合疗效提供了新策略。 目的 观察内镜下结扎联合中医辨证论治防治肝硬化食管静脉曲张破裂出血(EVB)二级预防的疗效.方法 选取2015年4月—2021年2月上海中医药大学附属曙光医院肝硬化科收治的行内镜下结扎治疗的EVB患者108例,对同时服用中药治疗的患者定义为中西医组(n=59),对未服用中药治疗的患者定义西医组(n=49).比较两组患者的再出血发生率、病死率以及门静脉高压性胃病的改善率等.计量资料符合正态分布者采用t检验;不符合正态分布者采用Mann-Whitney U秩和检验;计数资料2组间对比采用χ2检验或Fisher确切概率法;并采用Cox回归分析评估影响再出血的危险因素.结果 中西医组内镜结扎后13～24个月的再出血率显著低于西医组(2％vs 12％,P=0.045);中西医组再出血病死率显著低于西医组(2％vs 12％,P=0.045),且门静脉高压性胃病的总有效率显著高于西医组(90％vs 77％,P=0.04).基础疾病(主要包括糖尿病、高血压、心脏病)及肝功能Child-Pugh分级是影响再出血的显著危险因素(P值均<0.05).结论 内镜结扎联合中医辨证论治可显著降低EVB的迟发性再出血发生率和病死率,改善门静脉高压性胃病的程度,为结扎联合中医药提高EVB二级预防的综合疗效提供了新策略. |
| Author | 陈冲 刘平 慕永平 吕莹 陈茜蕾 刘成海 |
| AuthorAffiliation | 上海中医药大学附属曙光医院,上海市中医药研究院肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203 |
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| Author_FL | MU Yongping CHEN Chong LIU Chenghai LYU Ying CHEN Xilei LIU Ping |
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| Copyright | 2022. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| Keywords | 内窥镜检查 医学,中国传统 食管和胃静脉曲张 肝硬化 |
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| Publisher | Journal of Clinical Hepatology 上海中医药大学附属曙光医院,上海市中医药研究院肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203 |
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| Snippet | 目的 观察内镜下结扎联合中医辨证论治防治肝硬化食管静脉曲张破裂出血(EVB)二级预防的疗效。 方法 选取2015年4月—2021年2月上海中医药大学附属曙光医院肝硬化科收治的行内... 目的 观察内镜下结扎联合中医辨证论治防治肝硬化食管静脉曲张破裂出血(EVB)二级预防的疗效.方法 选取2015年4月—2021年2月上海中医药大学附属曙光医院肝硬化科收治的行内镜... |
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| SubjectTerms | Endoscopy Esophagus Hypertension Liver cirrhosis Mortality Traditional Chinese medicine |
| Title | 内镜结扎联合中医辨证论治对肝硬化食管静脉曲张破裂出血的二级预防效果 |
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