慢性胆汁淤积性肝病基础上发生药物性肝损伤的新见解与展望

慢性胆汁淤积性肝病患者发生疑似药物性肝损伤 (DILI) 的检测、评估和管理等方面存在诸多挑战，尤其是胆汁淤积性DILI在临床和组织学上可能与潜在的胆汁淤积性肝病的进展难以区分。目前，缺乏慢性胆汁淤积性肝病合并DILI的相关研究与管理规范。本文对慢性胆汁淤积性肝病合并DILI的潜在风险、因果关系及分型标准进行了探讨，以期提高临床工作者对该类疾病的认识，为其防治及管理策略提供参考。...

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Published inLinchuang gandanbing zazhi Vol. 41; no. 2; pp. 365 - 369
Main Authors 余思邈, 王伽伯, 肖小河, 王睿林
Format Journal Article
LanguageChinese
Published Changchun Journal of Clinical Hepatology 01.01.2025
中国人民解放军总医院第五医学中心中医肝病科,北京 100039%首都医科大学中医药学院,北京 100069
Subjects
Chemical and Drug Induced Liver Injury
Cholestatic Liver Disease
胆汁淤积性肝病
诊断,鉴别
Diagnosis,Differential
化学性与药物性肝损伤
Online AccessGet full text
ISSN1001-5256
2097-3497
DOI10.12449/JCH250225

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Abstract 慢性胆汁淤积性肝病患者发生疑似药物性肝损伤 (DILI) 的检测、评估和管理等方面存在诸多挑战，尤其是胆汁淤积性DILI在临床和组织学上可能与潜在的胆汁淤积性肝病的进展难以区分。目前，缺乏慢性胆汁淤积性肝病合并DILI的相关研究与管理规范。本文对慢性胆汁淤积性肝病合并DILI的潜在风险、因果关系及分型标准进行了探讨，以期提高临床工作者对该类疾病的认识，为其防治及管理策略提供参考。
AbstractList 慢性胆汁淤积性肝病患者发生疑似药物性肝损伤(DILI)的检测、评估和管理等方面存在诸多挑战,尤其是胆汁淤积性DILI在临床和组织学上可能与潜在的胆汁淤积性肝病的进展难以区分.目前,缺乏慢性胆汁淤积性肝病合并DILI的相关研究与管理规范.本文对慢性胆汁淤积性肝病合并DILI的潜在风险、因果关系及分型标准进行了探讨,以期提高临床工作者对该类疾病的认识,为其防治及管理策略提供参考.
慢性胆汁淤积性肝病患者发生疑似药物性肝损伤 (DILI) 的检测、评估和管理等方面存在诸多挑战，尤其是胆汁淤积性DILI在临床和组织学上可能与潜在的胆汁淤积性肝病的进展难以区分。目前，缺乏慢性胆汁淤积性肝病合并DILI的相关研究与管理规范。本文对慢性胆汁淤积性肝病合并DILI的潜在风险、因果关系及分型标准进行了探讨，以期提高临床工作者对该类疾病的认识，为其防治及管理策略提供参考。
Abstract_FL Patients with chronic cholestatic liver diseases face numerous challenges in the detection,assessment,and management of suspected drug-induced liver injury(DILI),and in particular,it is difficult to distinguish cholestatic DILI from the progression of underlying cholestatic liver diseases clinically and histologically.Currently,there is a lack of related research and management guidelines for DILI with chronic cholestatic liver diseases.This article discusses the potential risks,causality,and classification criteria for chronic cholestatic liver diseases with DILI,in order to improve the understanding of such diseases among clinicians and provide a reference for prevention,treatment,and management strategies.
Author 余思邈
王睿林
肖小河
王伽伯
AuthorAffiliation 中国人民解放军总医院第五医学中心中医肝病科,北京 100039%首都医科大学中医药学院,北京 100069
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Author_FL WANG Jiabo
WANG Ruilin
YU Simiao
XIAO Xiaohe
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Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
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Issue 2
Keywords Chemical and Drug Induced Liver Injury
Cholestatic Liver Disease
胆汁淤积性肝病
诊断,鉴别
Diagnosis,Differential
化学性与药物性肝损伤
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PublicationTitle_FL Journal of Clinical Hepatology
PublicationYear 2025
Publisher Journal of Clinical Hepatology
中国人民解放军总医院第五医学中心中医肝病科,北京 100039%首都医科大学中医药学院,北京 100069
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Snippet 慢性胆汁淤积性肝病患者发生疑似药物性肝损伤 (DILI) 的检测、评估和管理等方面存在诸多挑战，尤其是胆汁淤积性DILI在临床和组织学上可能与潜在的胆汁淤积性肝病的进展难以...
慢性胆汁淤积性肝病患者发生疑似药物性肝损伤(DILI)的检测、评估和管理等方面存在诸多挑战,尤其是胆汁淤积性DILI在临床和组织学上可能与潜在的胆汁淤积性肝病的进展难以区...
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