支链氨基酸在非酒精性脂肪性肝病发生发展中的作用
非酒精性脂肪性肝病是常见慢性肝病，有进展为非酒精性肝炎、肝纤维化和肝癌的风险，发病机制多样，其中支链氨基酸代谢异常可引起肝细胞氧化应激、自噬、线粒体功能障碍等，是导致非酒精性脂肪性肝病发生发展的最主要机制，对其进展进行综述，分析支链氨基酸代谢异常对非酒精性脂肪性肝病发生与发展的可能作用，以期提高临床认知与诊治水平。...
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| Published in | Linchuang gandanbing zazhi Vol. 38; no. 2; pp. 439 - 442 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.01.2022
兰州大学第二医院消化内科,兰州730030%兰州大学第二医院消化内科,兰州730030 中国人民解放军联勤保障部队第九四〇医院消化内科,兰州730050 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2022.02.037 |
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| Abstract | 非酒精性脂肪性肝病是常见慢性肝病，有进展为非酒精性肝炎、肝纤维化和肝癌的风险，发病机制多样，其中支链氨基酸代谢异常可引起肝细胞氧化应激、自噬、线粒体功能障碍等，是导致非酒精性脂肪性肝病发生发展的最主要机制，对其进展进行综述，分析支链氨基酸代谢异常对非酒精性脂肪性肝病发生与发展的可能作用，以期提高临床认知与诊治水平。 |
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| AbstractList | 非酒精性脂肪性肝病是常见慢性肝病,有进展为非酒精性肝炎、肝纤维化和肝癌的风险,发病机制多样,其中支链氨基酸代谢异常可引起肝细胞氧化应激、自噬、线粒体功能障碍等,是导致非酒精性脂肪性肝病发生发展的最主要机制,对其进展进行综述,分析支链氨基酸代谢异常对非酒精性脂肪性肝病发生与发展的可能作用,以期提高临床认知与诊治水平. 非酒精性脂肪性肝病是常见慢性肝病，有进展为非酒精性肝炎、肝纤维化和肝癌的风险，发病机制多样，其中支链氨基酸代谢异常可引起肝细胞氧化应激、自噬、线粒体功能障碍等，是导致非酒精性脂肪性肝病发生发展的最主要机制，对其进展进行综述，分析支链氨基酸代谢异常对非酒精性脂肪性肝病发生与发展的可能作用，以期提高临床认知与诊治水平。 |
| Author | 陈顺 谢小青 刘亚贤 于晓辉 |
| AuthorAffiliation | 中国人民解放军联勤保障部队第九四〇医院消化内科,兰州730050;兰州大学第二医院消化内科,兰州730030%兰州大学第二医院消化内科,兰州730030 |
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| Author_FL | XIE Xiaoqing YU Xiaohui LIU Yaxian CHEN Shun |
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| Keywords | 非酒精性脂肪性肝病;氨基酸类,支链;代谢 |
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| Publisher | Journal of Clinical Hepatology 兰州大学第二医院消化内科,兰州730030%兰州大学第二医院消化内科,兰州730030 中国人民解放军联勤保障部队第九四〇医院消化内科,兰州730050 |
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| Snippet | 非酒精性脂肪性肝病是常见慢性肝病，有进展为非酒精性肝炎、肝纤维化和肝癌的风险，发病机制多样，其中支链氨基酸代谢异常可引起肝细胞氧化应激、自噬、线粒体功能障碍等，是... 非酒精性脂肪性肝病是常见慢性肝病,有进展为非酒精性肝炎、肝纤维化和肝癌的风险,发病机制多样,其中支链氨基酸代谢异常可引起肝细胞氧化应激、自噬、线粒体功能障碍等,是导致... |
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| Title | 支链氨基酸在非酒精性脂肪性肝病发生发展中的作用 |
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