肝细胞癌相关胆汁酸代谢失衡及调控机制的研究进展
胆汁酸代谢、肠道菌群及胆汁酸受体调控通路均参与了肝细胞癌(HCC)发生发展的全过程。HCC小鼠模型的肝脏组织、HCC患者的血浆和粪便中某些胆汁酸如甘氨胆酸、牛磺胆酸、牛磺鹅去氧胆酸等水平均显著升高；肠道产胆盐水解酶细菌及梭状芽胞杆菌丰度失衡导致的胆汁酸代谢及机体免疫微环境的改变等也会促进HCC发生；此外，胆汁酸受体如法尼醇X受体、G蛋白偶联受体1、孕烷X受体、本构雄烷受体及鞘氨醇-1-磷酸受体2等多种受体亦被证实可以通过多种途径参与调控HCC的发生发展。胆汁酸代谢的各个环节在HCC的进程中发挥着不同的作用，系统诠释它们之间的相互作用有助于加深对HCC发病机制的认识，开发早期诊断、预后预测及精准...
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| Published in | Linchuang gandanbing zazhi Vol. 37; no. 3; pp. 690 - 694 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.01.2021
北京大学三〇二临床医学院,北京100039%解放军总医院第五医学中心肝脏肿瘤诊疗与研究中心,北京100039%北京大学三〇二临床医学院,北京100039 解放军总医院第五医学中心肝脏肿瘤诊疗与研究中心,北京100039 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2021.03.038 |
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| Abstract | 胆汁酸代谢、肠道菌群及胆汁酸受体调控通路均参与了肝细胞癌(HCC)发生发展的全过程。HCC小鼠模型的肝脏组织、HCC患者的血浆和粪便中某些胆汁酸如甘氨胆酸、牛磺胆酸、牛磺鹅去氧胆酸等水平均显著升高；肠道产胆盐水解酶细菌及梭状芽胞杆菌丰度失衡导致的胆汁酸代谢及机体免疫微环境的改变等也会促进HCC发生；此外，胆汁酸受体如法尼醇X受体、G蛋白偶联受体1、孕烷X受体、本构雄烷受体及鞘氨醇-1-磷酸受体2等多种受体亦被证实可以通过多种途径参与调控HCC的发生发展。胆汁酸代谢的各个环节在HCC的进程中发挥着不同的作用，系统诠释它们之间的相互作用有助于加深对HCC发病机制的认识，开发早期诊断、预后预测及精准治疗的生物靶标。 |
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| AbstractList | R735.7; 胆汁酸代谢、肠道菌群及胆汁酸受体调控通路均参与了肝细胞癌(HCC)发生发展的全过程.HCC小鼠模型的肝脏组织、HCC患者的血浆和粪便中某些胆汁酸如甘氨胆酸、牛磺胆酸、牛磺鹅去氧胆酸等水平均显著升高;肠道产胆盐水解酶细菌及梭状芽胞杆菌丰度失衡导致的胆汁酸代谢及机体免疫微环境的改变等也会促进HCC发生;此外,胆汁酸受体如法尼醇X受体、G蛋白偶联受体1、孕烷X受体、本构雄烷受体及鞘氨醇-1-磷酸受体2等多种受体亦被证实可以通过多种途径参与调控HCC的发生发展.胆汁酸代谢的各个环节在HCC的进程中发挥着不同的作用,系统诠释它们之间的相互作用有助于加深对HCC发病机制的认识,开发早期诊断、预后预测及精准治疗的生物靶标. 胆汁酸代谢、肠道菌群及胆汁酸受体调控通路均参与了肝细胞癌(HCC)发生发展的全过程。HCC小鼠模型的肝脏组织、HCC患者的血浆和粪便中某些胆汁酸如甘氨胆酸、牛磺胆酸、牛磺鹅去氧胆酸等水平均显著升高；肠道产胆盐水解酶细菌及梭状芽胞杆菌丰度失衡导致的胆汁酸代谢及机体免疫微环境的改变等也会促进HCC发生；此外，胆汁酸受体如法尼醇X受体、G蛋白偶联受体1、孕烷X受体、本构雄烷受体及鞘氨醇-1-磷酸受体2等多种受体亦被证实可以通过多种途径参与调控HCC的发生发展。胆汁酸代谢的各个环节在HCC的进程中发挥着不同的作用，系统诠释它们之间的相互作用有助于加深对HCC发病机制的认识，开发早期诊断、预后预测及精准治疗的生物靶标。 |
| Author | 陆荫英 贾晓东 刘哲睿 |
| AuthorAffiliation | 北京大学三〇二临床医学院,北京100039%解放军总医院第五医学中心肝脏肿瘤诊疗与研究中心,北京100039%北京大学三〇二临床医学院,北京100039;解放军总医院第五医学中心肝脏肿瘤诊疗与研究中心,北京100039 |
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| Author_FL | JIA Xiaodong LU Yinying LIU Zherui |
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| Title | 肝细胞癌相关胆汁酸代谢失衡及调控机制的研究进展 |
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