Effects of body parameters on renal cortical stiffness measured by shear-wave elastography in patients with kidney transplantation

• Published in: Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban Vol. 47; no. 10; p. 1385
• Main Authors: Yang, Shuting, Liu, Yuwan, Zuo, Huilan, Feng, Linna, Xu, Chengshu, Gu, Lan, Gao, Feng
• Format: Journal Article
• Language: Chinese; English
• Published: China 28.10.2022
• Subjects: Elasticity Imaging Techniques - methods; Humans; Kidney; Kidney Transplantation; Transplantation, Homologous; Ultrasonography - methods; hardness of renal cortex; shear-wave elastography; body parameters; body mass index; kidney transplantation
• ISSN: 1672-7347
• DOI: 10.11817/j.issn.1672-7347.2022.220170

The results of elastic imaging in evaluating the function and histopathological changes of allogeneic renal transplantation are contradictory, one of the important reasons may be that there are differences in human parameters related to kidney transplantation among individuals. The purpose of this study is to explore the related human body parameters on shear-wave elastography (SWE) effects on quantitative stiffness of graft cortex. From March 2021 to November 2021, a total of 63 patients with allogeneic kidney transplantation in the Department of Ultrasonography, Third Xiangya Hospital, Central South University, were selected to collect the parameters of two-dimensional, color Doppler and SWE. The subjects were divided into a <20% group and a 20%-30% group according to the variation of cortical hardness measurement. Mann Whitney test was used to compare the differences in relevant human parameters, and Spearman rank correlation was used to analyze the correlation between relevant human parameters and cortical hardness of transplanted kidney. There was no significant difference between the 2 groups in age, sex, postoperative time, resistance index of interlobar artery, SCr, blood uric acid, ratio of fat layer to muscle layer, and BMI (all >0.05). Compared with the <20% group, the patients in the 20%-30% group had smaller cortical hardness of the transplanted kidney, greater total distance between the transplanted kidney and the skin surface, and thicker fat layer or muscle layer in front of the transplanted kidney (all 0.05). The age of patients, the total distance from the transplanted kidney to the skin surface, the thickness of fat layer and muscle layer, the ratio of fat layer to muscle layer, BMI, and the variation of cortical hardness were significantly negatively correlated with the cortical hardness of the transplanted kidney (all 0.05). Human parameters relevant to kidney transplantation affect the accuracy of SWE in measuring the cortical hardness of the transplanted kidney. It is very important to obtain the highly stabile elastic measurement value and interpret the elastic measurement results according to different levels of human body related parameters in combination with individual conditions.