Anticardiolipin and anti-beta2-glycoprotein-I antibodies in preeclampsia

• Published in: Obstetrics and gynecology (New York. 1953) Vol. 102; no. 2; p. 294
• Main Authors: Lee, Richard M, Brown, Melissa A, Branch, D Ware, Ward, Kenneth, Silver, Robert M
• Format: Journal Article
• Language: English
• Published: United States 01.08.2003
• Subjects: Adult; Antibodies, Anticardiolipin - blood; Apolipoproteins - blood; beta 2-Glycoprotein I; Female; Glycoproteins - blood; HELLP Syndrome - immunology; Humans; Immunoglobulin G - blood; Immunoglobulin M - blood; Pre-Eclampsia - immunology; Pregnancy
• ISSN: 0029-7844
• DOI: 10.1016/s0029-7844(03)00477-0

To estimate whether antiphospholipid antibodies, specifically anticardiolipin and anti-beta(2)-glycoprotein-I antibodies, are associated with preeclampsia. Plasma was prospectively obtained from four groups of pregnant women: those with 1) mild preeclampsia (n = 109); 2) severe preeclampsia (n = 134); 3) hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome (n = 57); and 4) normotensive controls (n = 100). Anticardiolipin and anti-beta(2)-glycoprotein-I levels were determined by enzyme-linked immunoassay. Subjects with mild preeclampsia, severe preeclampsia, and HELLP syndrome did not have significantly elevated levels of immunoglobulin G (IgG) and IgM anticardiolipin and anti-beta(2)-glycoprotein-I antibodies compared with normotensive controls (P >.05, Kruskal-Wallis). Similarly, subjects with mild preeclampsia, severe preeclampsia, and HELLP syndrome did not have a significantly higher proportion of women testing positive for each autoantibody compared with normotensive controls (chi(2)). The proportion of patients testing positive for anticardiolipin and anti-beta(2)-glycoprotein-I antibodies were similar in patients with preeclampsia developing before and after 34 weeks' gestation (chi(2)). Circulating levels of both anticardiolipin and anti-beta(2)-glycoprotein-I antibodies were not increased in patients with mild preeclampsia, severe preeclampsia, or HELLP syndrome compared with normotensive controls. Our data do not support routine testing for anticardiolipin and anti-beta(2)-glycoprotein-I antibodies in women with preeclampsia.