ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity - Mewshaw, Richard E; Edsall, Jr, Richard J; Yang, Cuijian; Manas, Eric S; Xu, Zhang B; Henderson, Ruth A; Keith, Jr, James C; Harris, Heather A (Journal of medicinal chemistry, 2005)
Keywords: Animals; Animals, Genetically Modified; Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Arthritis, Experimental - drug therapy; Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Estrogen Receptor beta - agonists; Estrogen Receptor beta - chemistry; Female; Genistein - chemistry; Humans; Inflammatory Bowel Diseases - drug therapy; Ligands; Male; Models, Molecular; Molecular Conformation; Molecular Mimicry; Molecular Structure; Naphthalenes - chemical synthesis; Naphthalenes - chemistry; Naphthalenes - pharmacology; Naphthols - chemical synthesis; Naphthols - chemistry; Naphthols - pharmacology; Organ Size - drug effects; Rats; Rats, Inbred Lew; Structure-Activity Relationship; Transcription, Genetic - drug effects; Uterus - anatomy & histology; Uterus - drug effects