Corticosteroid cross‐reactivity: clinical and molecular modelling tools
To cite this article: Baeck M., Chemelle J.A., Goossens A., Nicolas J.F., Terreux R. Corticosteroid cross‐reactivity: clinical and molecular modelling tools. Allergy 2011; 66: 1367–1374. Background: Corticosteroids have been classified into following four cross‐reacting groups in function of their...
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| Published in | Allergy (Copenhagen) Vol. 66; no. 10; pp. 1367 - 1374 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.10.2011
Blackwell |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0105-4538 1398-9995 1398-9995 |
| DOI | 10.1111/j.1398-9995.2011.02666.x |
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| Abstract | To cite this article: Baeck M., Chemelle J.A., Goossens A., Nicolas J.F., Terreux R. Corticosteroid cross‐reactivity: clinical and molecular modelling tools. Allergy 2011; 66: 1367–1374.
Background: Corticosteroids have been classified into following four cross‐reacting groups in function of their contact‐allergenic properties: A, B, C and D, the last subdivided into D1 and D2. Recent data indicate that C16‐methylated and nonmethylated molecules need to be distinguished, the latter selectively binding with arginine to form stable cyclic adducts and producing considerably more positive reactions than the former. This study compares molecular modelling and patch‐test results to determine cross‐reactivity patterns.
Methods: The patch‐test results obtained with 66 corticosteroid molecules in 315 previously sensitized subjects were analysed and correlated with modelling and clustering in function of the electrostatic and steric fields of these molecules.
Results: The classification obtained after in silico hydrolysis of C21 and C17 esters was selected with an optimal cut into three clusters: the patients who reacted positively to cluster 2 (halogenated molecules from group B, with C16/C17 cis ketal or diol structure) and cluster 3 (halogenated molecules from groups C and D1, C16‐methylated) also reacted to cluster 1 (molecules mostly from groups A and D2, without C16‐methyl substitution or halogenation and budesonide). The reverse, however, was not the case.
Conclusion: Two patient profiles with probably different areas of immune recognition are identified as follows: the profile 1 patients were allergic to the frequently positively reacting cluster 1 only, for whom electrostatic fields (molecular charge) seem important; the profile 2 patients reacted to clusters 1 and 2 and/or 3, for whom steric fields (structure) are determinant and who probably presented a global recognition of the corticosteroid skeleton. A modified classification is thus proposed. |
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| AbstractList | Corticosteroids have been classified into following four cross-reacting groups in function of their contact-allergenic properties: A, B, C and D, the last subdivided into D1 and D2. Recent data indicate that C(16)-methylated and nonmethylated molecules need to be distinguished, the latter selectively binding with arginine to form stable cyclic adducts and producing considerably more positive reactions than the former. This study compares molecular modelling and patch-test results to determine cross-reactivity patterns.BACKGROUNDCorticosteroids have been classified into following four cross-reacting groups in function of their contact-allergenic properties: A, B, C and D, the last subdivided into D1 and D2. Recent data indicate that C(16)-methylated and nonmethylated molecules need to be distinguished, the latter selectively binding with arginine to form stable cyclic adducts and producing considerably more positive reactions than the former. This study compares molecular modelling and patch-test results to determine cross-reactivity patterns.The patch-test results obtained with 66 corticosteroid molecules in 315 previously sensitized subjects were analysed and correlated with modelling and clustering in function of the electrostatic and steric fields of these molecules.METHODSThe patch-test results obtained with 66 corticosteroid molecules in 315 previously sensitized subjects were analysed and correlated with modelling and clustering in function of the electrostatic and steric fields of these molecules.The classification obtained after in silico hydrolysis of C(21) and C(17) esters was selected with an optimal cut into three clusters: the patients who reacted positively to cluster 2 (halogenated molecules from group B, with C(16)/C(17) cis ketal or diol structure) and cluster 3 (halogenated molecules from groups C and D1, C(16)-methylated) also reacted to cluster 1 (molecules mostly from groups A and D2, without C(16)-methyl substitution or halogenation and budesonide). The reverse, however, was not the case.RESULTSThe classification obtained after in silico hydrolysis of C(21) and C(17) esters was selected with an optimal cut into three clusters: the patients who reacted positively to cluster 2 (halogenated molecules from group B, with C(16)/C(17) cis ketal or diol structure) and cluster 3 (halogenated molecules from groups C and D1, C(16)-methylated) also reacted to cluster 1 (molecules mostly from groups A and D2, without C(16)-methyl substitution or halogenation and budesonide). The reverse, however, was not the case.Two patient profiles with probably different areas of immune recognition are identified as follows: the profile 1 patients were allergic to the frequently positively reacting cluster 1 only, for whom electrostatic fields (molecular charge) seem important; the profile 2 patients reacted to clusters 1 and 2 and/or 3, for whom steric fields (structure) are determinant and who probably presented a global recognition of the corticosteroid skeleton. A modified classification is thus proposed.CONCLUSIONTwo patient profiles with probably different areas of immune recognition are identified as follows: the profile 1 patients were allergic to the frequently positively reacting cluster 1 only, for whom electrostatic fields (molecular charge) seem important; the profile 2 patients reacted to clusters 1 and 2 and/or 3, for whom steric fields (structure) are determinant and who probably presented a global recognition of the corticosteroid skeleton. A modified classification is thus proposed. To cite this article: Baeck M., Chemelle J.A., Goossens A., Nicolas J.F., Terreux R. Corticosteroid cross-reactivity: clinical and molecular modelling tools. Allergy 2011; 66: 1367-1374. Background: Corticosteroids have been classified into following four cross-reacting groups in function of their contact-allergenic properties: A, B, C and D, the last subdivided into D1 and D2. Recent data indicate that C16-methylated and nonmethylated molecules need to be distinguished, the latter selectively binding with arginine to form stable cyclic adducts and producing considerably more positive reactions than the former. This study compares molecular modelling and patch-test results to determine cross-reactivity patterns. Methods: The patch-test results obtained with 66 corticosteroid molecules in 315 previously sensitized subjects were analysed and correlated with modelling and clustering in function of the electrostatic and steric fields of these molecules. Results: The classification obtained after in silico hydrolysis of C21 and C17 esters was selected with an optimal cut into three clusters: the patients who reacted positively to cluster 2 (halogenated molecules from group B, with C16/C17 cis ketal or diol structure) and cluster 3 (halogenated molecules from groups C and D1, C16-methylated) also reacted to cluster 1 (molecules mostly from groups A and D2, without C16-methyl substitution or halogenation and budesonide). The reverse, however, was not the case. Conclusion: Two patient profiles with probably different areas of immune recognition are identified as follows: the profile 1 patients were allergic to the frequently positively reacting cluster 1 only, for whom electrostatic fields (molecular charge) seem important; the profile 2 patients reacted to clusters 1 and 2 and/or 3, for whom steric fields (structure) are determinant and who probably presented a global recognition of the corticosteroid skeleton. A modified classification is thus proposed. To cite this article: Baeck M., Chemelle J.A., Goossens A., Nicolas J.F., Terreux R. Corticosteroid cross‐reactivity: clinical and molecular modelling tools. Allergy 2011; 66: 1367–1374. Background: Corticosteroids have been classified into following four cross‐reacting groups in function of their contact‐allergenic properties: A, B, C and D, the last subdivided into D1 and D2. Recent data indicate that C16‐methylated and nonmethylated molecules need to be distinguished, the latter selectively binding with arginine to form stable cyclic adducts and producing considerably more positive reactions than the former. This study compares molecular modelling and patch‐test results to determine cross‐reactivity patterns. Methods: The patch‐test results obtained with 66 corticosteroid molecules in 315 previously sensitized subjects were analysed and correlated with modelling and clustering in function of the electrostatic and steric fields of these molecules. Results: The classification obtained after in silico hydrolysis of C21 and C17 esters was selected with an optimal cut into three clusters: the patients who reacted positively to cluster 2 (halogenated molecules from group B, with C16/C17 cis ketal or diol structure) and cluster 3 (halogenated molecules from groups C and D1, C16‐methylated) also reacted to cluster 1 (molecules mostly from groups A and D2, without C16‐methyl substitution or halogenation and budesonide). The reverse, however, was not the case. Conclusion: Two patient profiles with probably different areas of immune recognition are identified as follows: the profile 1 patients were allergic to the frequently positively reacting cluster 1 only, for whom electrostatic fields (molecular charge) seem important; the profile 2 patients reacted to clusters 1 and 2 and/or 3, for whom steric fields (structure) are determinant and who probably presented a global recognition of the corticosteroid skeleton. A modified classification is thus proposed. Corticosteroids have been classified into following four cross-reacting groups in function of their contact-allergenic properties: A, B, C and D, the last subdivided into D1 and D2. Recent data indicate that C(16)-methylated and nonmethylated molecules need to be distinguished, the latter selectively binding with arginine to form stable cyclic adducts and producing considerably more positive reactions than the former. This study compares molecular modelling and patch-test results to determine cross-reactivity patterns. The patch-test results obtained with 66 corticosteroid molecules in 315 previously sensitized subjects were analysed and correlated with modelling and clustering in function of the electrostatic and steric fields of these molecules. The classification obtained after in silico hydrolysis of C(21) and C(17) esters was selected with an optimal cut into three clusters: the patients who reacted positively to cluster 2 (halogenated molecules from group B, with C(16)/C(17) cis ketal or diol structure) and cluster 3 (halogenated molecules from groups C and D1, C(16)-methylated) also reacted to cluster 1 (molecules mostly from groups A and D2, without C(16)-methyl substitution or halogenation and budesonide). The reverse, however, was not the case. Two patient profiles with probably different areas of immune recognition are identified as follows: the profile 1 patients were allergic to the frequently positively reacting cluster 1 only, for whom electrostatic fields (molecular charge) seem important; the profile 2 patients reacted to clusters 1 and 2 and/or 3, for whom steric fields (structure) are determinant and who probably presented a global recognition of the corticosteroid skeleton. A modified classification is thus proposed. Background: Corticosteroids have been classified into following four cross-reacting groups in function of their contact-allergenic properties: A, B, C and D, the last subdivided into D1 and D2. Recent data indicate that C16-methylated and nonmethylated molecules need to be distinguished, the latter selectively binding with arginine to form stable cyclic adducts and producing considerably more positive reactions than the former. This study compares molecular modeling and patch-test results to determine cross-reactivity patterns. Methods: The patch-test results obtained with 66 corticosteroid molecules in 315 previously sensitized subjects were analyzed and correlated with modeling and clustering in function of the electrostatic and steric fields of these molecules. Results: The classification obtained after in silico hydrolysis of C21 and C17 esters was selected with an optimal cut into three clusters: the patients who reacted positively to cluster 2 (halogenated molecules from group B, with C16/C17 cis ketal or diol structure) and cluster 3 (halogenated molecules from groups C and D1, C16-methylated) also reacted to cluster 1 (molecules mostly from groups A and D2, without C16-methyl substitution or halogenation and budesonide). The reverse, however, was not the case. Conclusion: Two patient profiles with probably different areas of immune recognition are identified as follows: the profile 1 patients were allergic to the frequently positively reacting cluster 1 only, for whom electrostatic fields (molecular charge) seem important; the profile 2 patients reacted to clusters 1 and 2 and/or 3, for whom steric fields (structure) are determinant and who probably presented a global recognition of the corticosteroid skeleton. A modified classification is thus proposed. [PUBLICATION ABSTRACT] |
| Author | Terreux, R. Goossens, A. Nicolas, J. F. Chemelle, J. A. Baeck, M. |
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| Keywords | Allergy Corticosteroid Immunopathology Immunology corticosteroids Dermatology molecular modelling Classification Cross reaction Delayed hypersensitivity delayed allergic hypersensitivity cross-reactions |
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| References_xml | – volume: 42 start-page: 59 year: 2000 end-page: 63 article-title: Corticosteroid cross‐reactions: an alternative view publication-title: Contact Dermatitis – volume: 58 start-page: 10 issue: suppl.1 year: 2008 article-title: Allergic contact dermatitis to corticosteroids: a mechanistic study publication-title: Contact Dermatitis – volume: 40 start-page: 24 year: 1999 end-page: 31 article-title: Patch testing with budesonide in serial dilutions: the significance of dose, occlusion time and reading time publication-title: Contact Dermatitis – volume: 63 start-page: 14 issue: suppl.1 year: 2010 article-title: Allergic contact dermatitis to corticosteroids: group A vs. group C, a mechanistic study publication-title: Contact Dermatitis – volume: 17 start-page: 490 year: 1996 end-page: 519 article-title: Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94 publication-title: J Comput Chem – volume: 47 start-page: 123 year: 2002 end-page: 124 article-title: Comparative testing with budesonide in petrolatum and ethanol in a standard series publication-title: Contact Dermatitis – volume: 35 start-page: 1671 year: 1992 end-page: 1684 article-title: Definition and display of steric, hydrophobic, and hydrogen‐bonding properties of ligand binding sites in proteins using lee and richards accessible surfaces: validation of a high‐resolution tool for drug design publication-title: J Med Chem – volume: 64 start-page: 305 year: 2011 end-page: 312 article-title: C ‐methyl corticosteroids are far less allergenic than the non‐methylated molecules publication-title: Contact Dermatitis – volume: 49 start-page: 53 year: 2003 end-page: 54 article-title: Corticosteroid cross‐reactivity publication-title: Contact Dermatitis – volume: 131 start-page: 31 year: 1995 end-page: 37 article-title: Studies in patients with corticosteroid contact allergy: understanding cross‐reactivity among different steroids publication-title: Arch Dermatol – year: 2008 – volume: 34 start-page: 305 year: 1996 end-page: 308 article-title: Corticosteroid contact hypersensitivity: what vehicle and concentration? publication-title: Contact Dermatitis – volume: 10 start-page: 31 year: 1999 end-page: 33 article-title: The benefit of patch testing with a corticosteroid at a low concentration publication-title: Am J Contact Dermat – volume: 9 start-page: 205 year: 1995 end-page: 212 article-title: Replacement of steric 6‐12 potential‐derived interaction energies by atom based indicator variables in CoMFA leads to models of higher consistency publication-title: J Comput Aided Mol Des – volume: 43 start-page: 41 year: 2000 end-page: 63 article-title: Recommendation to include budesonide and tixocortol pivalate in the European standard series publication-title: Contact Dermatitis – volume: 61 start-page: 163 year: 2009 end-page: 175 article-title: Delayed hypersensitivity to corticosteroids in a series of 315 patients: clinical data and patch‐test results publication-title: Contact Dermatitis – volume: 55 start-page: 698 year: 2000 end-page: 704 article-title: Contact allergy to corticosteroids publication-title: Allergy – volume: 121 start-page: 27 year: 1989 end-page: 34 article-title: Identification of cross‐reaction patterns in allergic contact dermatitis from topical corticosteroids publication-title: Br J Dermatol – volume: 135 start-page: 225 year: 1996 end-page: 230 article-title: Corticosteroid usage and binding to arginine. Determinants of corticosteroid hypersensitivity publication-title: Br J Dermatol – year: 1998 – volume: 12 start-page: 170 year: 2001 end-page: 176 article-title: Patch testing with serial dilutions of budesonide, its R and S diastereomers, and potentially cross‐reacting substances publication-title: Am J Contact Dermat |
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| Snippet | To cite this article: Baeck M., Chemelle J.A., Goossens A., Nicolas J.F., Terreux R. Corticosteroid cross‐reactivity: clinical and molecular modelling tools.... Corticosteroids have been classified into following four cross-reacting groups in function of their contact-allergenic properties: A, B, C and D, the last... Background: Corticosteroids have been classified into following four cross-reacting groups in function of their contact-allergenic properties: A, B, C and D,... To cite this article: Baeck M., Chemelle J.A., Goossens A., Nicolas J.F., Terreux R. Corticosteroid cross-reactivity: clinical and molecular modelling tools.... |
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| SubjectTerms | Adducts Adrenal Cortex Hormones - chemistry Adrenal Cortex Hormones - classification Adrenal Cortex Hormones - immunology Allergic diseases Allergies Arginine Biological and medical sciences budesonide Classification Corticoids corticosteroids Cross-reactivity cross‐reactions Data processing delayed allergic hypersensitivity Dermatology Electrostatic properties Esters Fundamental and applied biological sciences. Psychology Fundamental immunology Hormones Humans Hydrolysis Hypersensitivity Immunopathology Medical sciences Models, Molecular Molecular modelling Molecules Patch Tests Quantitative Structure-Activity Relationship Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin allergic diseases. Stinging insect allergies |
| Title | Corticosteroid cross‐reactivity: clinical and molecular modelling tools |
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