More than just hype
[Louise Pilote](1) implies that physicians who prescribed ramipril to more of their diabetic patients after the results of the HOPE study were publicized did so primarily because of marketing hype rather than solid research evidence. As a clinical epidemiologist and diabetes specialist, I am baffled...
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| Published in | Canadian Medical Association journal (CMAJ) Vol. 168; no. 13; pp. 1646; author reply 1647 - 1646 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Canada
CMA Impact, Inc
24.06.2003
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0820-3946 1488-2329 |
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| Abstract | [Louise Pilote](1) implies that physicians who prescribed ramipril to more of their diabetic patients after the results of the HOPE study were publicized did so primarily because of marketing hype rather than solid research evidence. As a clinical epidemiologist and diabetes specialist, I am baffled by this position. The HOPE study(2)(3) was by far the largest clinical trial evaluating an ACE inhibitor and enrolled a much broader clinical population than its predecessors. It included a prespecified subgroup of 3577 diabetic participants, possibly more than the total number of diabetic subjects enrolled in all previous ACE inhibitor trials. Diabetic (and nondiabetic) subjects assigned to receive ramipril had statistically and clinically significant risk reductions for major cardiovascular events. |
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| AbstractList | [Louise Pilote](1) implies that physicians who prescribed ramipril to more of their diabetic patients after the results of the HOPE study were publicized did so primarily because of marketing hype rather than solid research evidence. As a clinical epidemiologist and diabetes specialist, I am baffled by this position. The HOPE study(2)(3) was by far the largest clinical trial evaluating an ACE inhibitor and enrolled a much broader clinical population than its predecessors. It included a prespecified subgroup of 3577 diabetic participants, possibly more than the total number of diabetic subjects enrolled in all previous ACE inhibitor trials. Diabetic (and nondiabetic) subjects assigned to receive ramipril had statistically and clinically significant risk reductions for major cardiovascular events. A headline appearing in the highlights section of the March 4, 2003, issue of CMAJ was "The hype around HOPE," in reference to an article by Karen Tu and colleagues(1) and an accompanying commentary by Louise Pilote.(2) This expression was an appropriate play on words to describe changes in the prescribing of ramipril after publication of results from the large Canadian-led HOPE trial. (1) Tu K, Mamdani MM, Jacka RM, Forde NJ, Rothwell DM, Tu JV. The striking effect of the Heart Outcomes Prevention Evaluation (HOPE) on ramipril prescribing in Ontario. CMAJ 2003;168(5):553-7. |
| Author | Yusuf, Salim Dagenais, Gilles |
| AuthorAffiliation | Professor of Medicine, McMaster University, Hamilton, Ont.; †Professor Emeritus, Laval University, Sainte-Foy, Que |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12821614$$D View this record in MEDLINE/PubMed |
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| References | 12615751 - CMAJ. 2003 Mar 4;168(5):568-9 11303006 - Heart. 2001 May;85(5):539-43 12615747 - CMAJ. 2003 Mar 4;168(5):553-7 9788454 - Lancet. 1998 Oct 17;352(9136):1252-6 12028506 - J Intern Med. 2002 Jun;251(6):508-17 12600907 - Circulation. 2003 Feb 25;107(7):960-5 10639539 - N Engl J Med. 2000 Jan 20;342(3):145-53 12639157 - Ann Pharmacother. 2003 Mar;37(3):327-31 8104270 - Lancet. 1993 Oct 2;342(8875):821-8 7654275 - JAMA. 1995 May 10;273(18):1450-6 12435255 - JAMA. 2002 Nov 20;288(19):2421-31 |
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| Snippet | [Louise Pilote](1) implies that physicians who prescribed ramipril to more of their diabetic patients after the results of the HOPE study were publicized did... A headline appearing in the highlights section of the March 4, 2003, issue of CMAJ was "The hype around HOPE," in reference to an article by Karen Tu and... |
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| SubjectTerms | Angiotensin-Converting Enzyme Inhibitors - economics Angiotensin-Converting Enzyme Inhibitors - therapeutic use Canada Cardiovascular disease Cardiovascular Diseases - prevention & control Clinical Trials as Topic Cost-Benefit Analysis Drugs Humans Letters Physiological aspects Ramipril - economics Ramipril - therapeutic use Treatment |
| Title | More than just hype |
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