Evaluation of the Dysregulation of Cholesterol and Glucose Levels in Graves' Disease Using Clinical Data Analysis

• Published in: Reports of Biochemistry and Molecular Biology Vol. 13; no. 2; pp. 159 - 166
• Main Authors: Kareem, Zainab Razaq, Al-Kazazz, Fatin Fadhel, Rheima, Ahmed Mahdi, Sultan, Ameer Radhi
• Format: Journal Article
• Language: English
• Published: Iran Varastegan Institute for Medical Sciences 01.07.2024
• Subjects: Original; Glucose; Graves’ disease; Hyperthyroidism; Cholesterol; Autoimmune Thyroid disease
• ISSN: 2322-3480; 1024-9869; 2322-3480
• DOI: 10.61186/rbmb.13.2.159

Graves' disease (GD) is the most frequent reason for hyperthyroidism, which is brought on by an excess of thyroid hormone and a form of autoimmune thyroid disease (AITD). Patients with GD have higher levels of thyroid receptor antibody (TRAb). The current study, investigates the impact of excessive thyroid hormone production on glucose and cholesterol metabolism in thyroid disorders, particularly focusing on GD. This study included 96 subjects (32 GD patients, 32 from non-autoimmune hyperthyroidism and 32 from healthy controls). All samples were obtained from Al-Kadhimiya Teaching Hospital (Baghdad) for the period between September 2023 and January 2024. The results revealed that mean± SD values of FT3 and FT4 for GD patients were significantly higher (P<0.001) accompanied by a significant decrease in mean±SD values of TSH (P<0.001) when compared to non-autoimmune hyperthyroidism and control groups. Conversely, TC and glucose levels did not show significant variations among GD patients, the non-immune hyperthyroidism and control groups (P > 0.05). Our findings indicated thyroid function analysis is crucial for the diagnosis and differentiation of GD, TC and glucose levels do not contribute additional discriminatory power.