Multifunctional molecule ERp57: From cancer to neurodegenerative diseases

The protein disulfide isomerase (PDI) gene family is a protein family classically characterized by endoplasmic reticulum (ER) localization and isomerase and redox activity. ERp57, a prominent multifunctional member of the PDI family, is detected at various levels in multiple cellular localizations o...

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Bibliographic Details
Published inPharmacology & therapeutics (Oxford) Vol. 181; pp. 34 - 48
Main Authors Hettinghouse, Aubryanna, Liu, Ronghan, Liu, Chuan-Ju
Format Journal Article
LanguageEnglish
Published England 01.01.2018
Subjects
Animals
Humans
Neoplasms - physiopathology
Neurodegenerative Diseases - physiopathology
Protein Disulfide-Isomerases - metabolism
Musculoskeletal system
Immune response
Clinical biomarker
Neurodegeneration
ERp57/PDIA3
Cancer
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ISSN1879-016X
0163-7258
1879-016X
DOI10.1016/j.pharmthera.2017.07.011

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Summary:The protein disulfide isomerase (PDI) gene family is a protein family classically characterized by endoplasmic reticulum (ER) localization and isomerase and redox activity. ERp57, a prominent multifunctional member of the PDI family, is detected at various levels in multiple cellular localizations outside of the ER. ERp57 has been functionally linked to a host of physiological processes and numerous studies have demonstrated altered expression and aberrant functionality of ERp57 in association with diverse pathological states. Here, we summarize available knowledge of ERp57's functions in subcellular compartments and the roles of dysregulated ERp57 in various diseases toward an emphasis on the potential utility of therapeutic development of ERp57.
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Authors contribute equally.
ISSN:1879-016X
0163-7258
1879-016X
DOI:10.1016/j.pharmthera.2017.07.011