TMV Particles: The Journey From Fundamental Studies to Bionanotechnology Applications

• Published in: Advances in virus research Vol. 102; pp. 149 - 176
• Main Authors: Lomonossoff, George P, Wege, Christina
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 2018
• Subjects: Biosensing Techniques; Capsid; Gene Expression; Genome, Viral; History, 20th Century; History, 21st Century; Nanotechnology - history; Nanotechnology - instrumentation; Nanotechnology - methods; Nanotubes - chemistry; Nanotubes - virology; Peptide Library; Plant Diseases - virology; Plant Pathology - history; Plants - virology; Protein Engineering - methods; Tissue Engineering - methods; Tobacco Mosaic Virus - genetics; Tobacco Mosaic Virus - metabolism; Tobacco Mosaic Virus - ultrastructure; Viral Proteins - chemistry; Viral Proteins - genetics; Viral Proteins - metabolism; Virion - genetics; Virion - metabolism; Virion - ultrastructure; Nanostars; Chemical modification; Origin of assembly; Self-assembly; Nanorings; Peptide presentation; Coat protein
• ISSN: 1557-8399; 0065-3527; 1557-8399
• DOI: 10.1016/bs.aivir.2018.06.003

Ever since its initial characterization in the 19th century, tobacco mosaic virus (TMV) has played a prominent role in the development of modern virology and molecular biology. In particular, research on the three-dimensional structure of the virus particles and the mechanism by which these assemble from their constituent protein and RNA components has made TMV a paradigm for our current view of the morphogenesis of self-assembling structures, including viral particles. More recently, this knowledge has been applied to the development of novel reagents and structures for applications in biomedicine and bionanotechnology. In this article, we review how fundamental science has led to TMV being at the vanguard of these new technologies.