PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate - Chessa, Tamara A M; Jung, Piotr; Anwar, Arqum; Suire, Sabine; Anderson, Karen E; Barneda, David; Kielkowska, Anna; Sadiq, Barzan A; Lai, Ieng Wai; Felisbino, Sergio; Turnham, Daniel J; Pearson, Helen B; et al. (Molecular cell, 2023)
Keywords: Animals; Homeostasis; Humans; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Male; metabolism; Mice; neoplasm progression; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; phosphorylation; Prostate - pathology; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; tyrosine; PTEN; prostate; PI3K; IRS1; PLEKHS1; Src-family kinase