Capillary angiogenesis and remodeling induced in rat limb by arteriovenous shunting

Capillary angiogenesis and remodeling induced by arteriovenous (AV) shunting in rat hind limb was investigated by evaluating changes in capillary density and diameter in the skeletal muscle subject to retrograde flow and high pressure. Wistar rats were used, and an AV anastomosis was created in the...

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Published inClinical hemorheology and microcirculation Vol. 32; no. 3; pp. 199 - 208
Main Authors Komai, Yutaka, Nakano, Atushi, Niimi, Hideyuki
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.01.2005
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ISSN1386-0291
1875-8622
DOI10.3233/CHM-2005-753

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Abstract Capillary angiogenesis and remodeling induced by arteriovenous (AV) shunting in rat hind limb was investigated by evaluating changes in capillary density and diameter in the skeletal muscle subject to retrograde flow and high pressure. Wistar rats were used, and an AV anastomosis was created in the hind limb. Two weeks after AV shunting, the microvasculature in the limb was visualized by GS‐lectine, and the samples were observed using confocal laser microscopy. The capillary density were increased by approximately 150% for small vessels (<13 μm in diameter) under retrograde flow condition, but no change appeared for large vessels (>13 μm in diameter). The capillary diameters were not significantly different between control and chronic condition. In conclusion, retrograde flow produced by AV shunting increased capillary density but it did not change the capillary diameter significantly.
AbstractList Capillary angiogenesis and remodeling induced by arteriovenous (AV) shunting in rat hind limb was investigated by evaluating changes in capillary density and diameter in the skeletal muscle subject to retrograde flow and high pressure. Wistar rats were used, and an AV anastomosis was created in the hind limb. Two weeks after AV shunting, the microvasculature in the limb was visualized by GS‐lectine, and the samples were observed using confocal laser microscopy. The capillary density were increased by approximately 150% for small vessels (<13 μm in diameter) under retrograde flow condition, but no change appeared for large vessels (>13 μm in diameter). The capillary diameters were not significantly different between control and chronic condition. In conclusion, retrograde flow produced by AV shunting increased capillary density but it did not change the capillary diameter significantly.
Capillary angiogenesis and remodeling induced by arteriovenous (AV) shunting in rat hind limb was investigated by evaluating changes in capillary density and diameter in the skeletal muscle subject to retrograde flow and high pressure. Wistar rats were used, and an AV anastomosis was created in the hind limb. Two weeks after AV shunting, the microvasculature in the limb was visualized by GS-lectine, and the samples were observed using confocal laser microscopy. The capillary density were increased by approximately 150% for small vessels (<13 microm in diameter) under retrograde flow condition, but no change appeared for large vessels (>13 microm in diameter). The capillary diameters were not significantly different between control and chronic condition. In conclusion, retrograde flow produced by AV shunting increased capillary density but it did not change the capillary diameter significantly.
Capillary angiogenesis and remodeling induced by arteriovenous (AV) shunting in rat hind limb was investigated by evaluating changes in capillary density and diameter in the skeletal muscle subject to retrograde flow and high pressure. Wistar rats were used, and an AV anastomosis was created in the hind limb. Two weeks after AV shunting, the microvasculature in the limb was visualized by GS-lectine, and the samples were observed using confocal laser microscopy. The capillary density were increased by approximately 150% for small vessels (<13 microm in diameter) under retrograde flow condition, but no change appeared for large vessels (>13 microm in diameter). The capillary diameters were not significantly different between control and chronic condition. In conclusion, retrograde flow produced by AV shunting increased capillary density but it did not change the capillary diameter significantly.Capillary angiogenesis and remodeling induced by arteriovenous (AV) shunting in rat hind limb was investigated by evaluating changes in capillary density and diameter in the skeletal muscle subject to retrograde flow and high pressure. Wistar rats were used, and an AV anastomosis was created in the hind limb. Two weeks after AV shunting, the microvasculature in the limb was visualized by GS-lectine, and the samples were observed using confocal laser microscopy. The capillary density were increased by approximately 150% for small vessels (<13 microm in diameter) under retrograde flow condition, but no change appeared for large vessels (>13 microm in diameter). The capillary diameters were not significantly different between control and chronic condition. In conclusion, retrograde flow produced by AV shunting increased capillary density but it did not change the capillary diameter significantly.
Author Komai, Yutaka
Niimi, Hideyuki
Nakano, Atushi
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Keywords Angiogenesis
capillary density
confocal laser microscopy
limb microcirculation
vein graft
retrograde flow
arteriovenous shunt
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SubjectTerms Animals
Arteriovenous Anastomosis - metabolism
Arteriovenous Shunt, Surgical - methods
Capillaries - pathology
Capillaries - ultrastructure
Lower Extremity - blood supply
Male
Microcirculation
Microscopy, Confocal
Models, Biological
Neovascularization, Physiologic
Rats
Rats, Wistar
Reperfusion
Time Factors
Title Capillary angiogenesis and remodeling induced in rat limb by arteriovenous shunting
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