Electrochemical hydrocarboxylation of enol derivatives with CO2: access to β-acetoxycarboxylic acids

Electrochemical hydrocarboxylation of enol acetates with CO2 is developed. The disclosed process provides beta-acetoxycarboxylic acids in 25-66% yields, in contrast to the electrolysis of ketones, silyl enol ethers and vinyl tosylates with CO2, which leads mainly to alcohols.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 60; no. 62; pp. 8099 - 8102
Main Authors Ustyuzhanin, Alexander O., Bityukov, Oleg V., Sokolovskiy, Pavel V., Merkulova, Valentina M., Ilovaisky, Alexey I., He, Liang-Nian, Vil', Vera A., Terent'ev, Alexander O.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 30.07.2024
Royal Society of Chemistry
Subjects
Acetates
Alcohols
Carbon dioxide
Chemistry
Chemistry, Multidisciplinary
Electrolysis
Ethers
Ketones
Physical Sciences
Science & Technology
FACILE SYNTHESIS
AROMATIC KETONES
REDUCTION
OPERATIVE PARAMETERS
CARBON-DIOXIDE
ELECTROCARBOXYLATION
CARBOXYLIC-ACIDS
Online AccessGet full text
ISSN1359-7345
1364-548X
1364-548X
DOI10.1039/d4cc02831g

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Summary:Electrochemical hydrocarboxylation of enol acetates with CO2 is developed. The disclosed process provides beta-acetoxycarboxylic acids in 25-66% yields, in contrast to the electrolysis of ketones, silyl enol ethers and vinyl tosylates with CO2, which leads mainly to alcohols.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc02831g