A quantitative and qualitative evaluation of LISA, a decision support system for chemotherapy dosing in childhood acute lymphoblastic leukaemia

• Published in: Studies in health technology and informatics Vol. 107; no. Pt 1; p. 197
• Main Authors: Bury, Jonathan, Hurt, Chris, Roy, Anindita, Bradburn, Mike, Cross, Simon, Fox, John, Saha, Vaskar
• Format: Journal Article
• Language: English
• Published: Netherlands 2004
• Subjects: Antineoplastic Agents - administration & dosage; Attitude to Computers; Cross-Over Studies; Decision Support Systems, Clinical; Drug Therapy, Computer-Assisted; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Surveys and Questionnaires
• ISSN: 0926-9630
• DOI: 10.3233/978-1-60750-949-3-197

To assess the acceptability to clinicians of a web-based decision support system designed to assist with dosage adjustments during maintenance therapy for childhood Acute Lymphoblastic Leukaemia (ALL), and to evaluate the potential impact of the system on decision-making and dosage calculations. Balanced-block crossover experiment with simulated cases; questionnaire study and semi-structured interviews. 36 clinicians with differing experience in the management of ALL. Subjects were asked to decide on appropriate levels of chemotherapy dosing for 8 simulated cases, 4 using the LISA decision support system, 4 using conventional paper-based records and guidance. Number of protocol-consistent dosage decisions made; time taken to manage each case; accuracy of dosage calculations; subjects' opinions as to whether or not they would use the system in practice. ADDITIONAL OUTCOME MEASURES: Functions subjects would like to see in an idealised system; subjects' satisfaction with the implementation of the functions provided by LISA; qualitative data on issues subjects felt would impact upon the successful deployment of the system.