Correlation between alveolar recruitment/derecruitment and inflection points on the pressure-volume curve
To determine whether individual alveolar recruitment/derecruitment (R/D) is correlated with the lower and upper inflections points on the inflation and deflation limb of the whole-lung pressure-volume (P-V) curve. Prospective experimental study in an animal research laboratory. Five anesthetized rat...
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| Published in | Intensive care medicine Vol. 33; no. 7; pp. 1204 - 1211 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Springer Nature B.V
01.07.2007
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0342-4642 1432-1238 |
| DOI | 10.1007/s00134-007-0629-8 |
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| Abstract | To determine whether individual alveolar recruitment/derecruitment (R/D) is correlated with the lower and upper inflections points on the inflation and deflation limb of the whole-lung pressure-volume (P-V) curve.
Prospective experimental study in an animal research laboratory.
Five anesthetized rats subjected to saline-lavage lung injury.
Subpleural alveoli were filmed continuously using an in vivo microscope during the generation of a whole-lung P-V curve using the super syringe technique. Alveolar R/D was correlated to the calculated inflection points on both limbs of the P-V curve.
There was continual alveolar recruitment along the entire inflation limb in all animals. There was some correlation (R2=0.898) between the pressure below which microscopic derecruitment was observed and the upper inflection point on the deflation limb. No correlation was observed between this pressure and the lower inflection point on the inflation limb.
In this physiological experiment in lungs with pure surfactant deactivation we found that individual alveolar recruitment measured by direct visualization was not correlated with the lower inflection point on inflation whereas alveolar derecruitment was correlated with alveolar derecruitment on deflation. These data suggest that inflection points on the P-V curve do not always represent a change in alveolar number. |
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| AbstractList | To determine whether individual alveolar recruitment/derecruitment (R/D) is correlated with the lower and upper inflections points on the inflation and deflation limb of the whole-lung pressure-volume (P-V) curve.
Prospective experimental study in an animal research laboratory.
Five anesthetized rats subjected to saline-lavage lung injury.
Subpleural alveoli were filmed continuously using an in vivo microscope during the generation of a whole-lung P-V curve using the super syringe technique. Alveolar R/D was correlated to the calculated inflection points on both limbs of the P-V curve.
There was continual alveolar recruitment along the entire inflation limb in all animals. There was some correlation (R2=0.898) between the pressure below which microscopic derecruitment was observed and the upper inflection point on the deflation limb. No correlation was observed between this pressure and the lower inflection point on the inflation limb.
In this physiological experiment in lungs with pure surfactant deactivation we found that individual alveolar recruitment measured by direct visualization was not correlated with the lower inflection point on inflation whereas alveolar derecruitment was correlated with alveolar derecruitment on deflation. These data suggest that inflection points on the P-V curve do not always represent a change in alveolar number. ObjectiveTo determine whether individual alveolar recruitment/derecruitment (R/D) is correlated with the lower and upper inflections points on the inflation and deflation limb of the whole-lung pressure-volume (P-V) curve.Design and settingProspective experimental study in an animal research laboratory.SubjectsFive anesthetized rats subjected to saline-lavage lung injury.InterventionsSubpleural alveoli were filmed continuously using an in vivo microscope during the generation of a whole-lung P-V curve using the super syringe technique. Alveolar R/D was correlated to the calculated inflection points on both limbs of the P-V curve.Measurements and resultsThere was continual alveolar recruitment along the entire inflation limb in all animals. There was some correlation (R2 = 0.898) between the pressure below which microscopic derecruitment was observed and the upper inflection point on the deflation limb. No correlation was observed between this pressure and the lower inflection point on the inflation limb.ConclusionsIn this physiological experiment in lungs with pure surfactant deactivation we found that individual alveolar recruitment measured by direct visualization was not correlated with the lower inflection point on inflation whereas alveolar derecruitment was correlated with alveolar derecruitment on deflation. These data suggest that inflection points on the P-V curve do not always represent a change in alveolar number. To determine whether individual alveolar recruitment/derecruitment (R/D) is correlated with the lower and upper inflections points on the inflation and deflation limb of the whole-lung pressure-volume (P-V) curve. Prospective experimental study in an animal research laboratory. Five anesthetized rats subjected to saline-lavage lung injury. Subpleural alveoli were filmed continuously using an in vivo microscope during the generation of a whole-lung P-V curve using the super syringe technique. Alveolar R/D was correlated to the calculated inflection points on both limbs of the P-V curve. There was continual alveolar recruitment along the entire inflation limb in all animals. There was some correlation (R2=0.898) between the pressure below which microscopic derecruitment was observed and the upper inflection point on the deflation limb. No correlation was observed between this pressure and the lower inflection point on the inflation limb. In this physiological experiment in lungs with pure surfactant deactivation we found that individual alveolar recruitment measured by direct visualization was not correlated with the lower inflection point on inflation whereas alveolar derecruitment was correlated with alveolar derecruitment on deflation. These data suggest that inflection points on the P-V curve do not always represent a change in alveolar number. To determine whether individual alveolar recruitment/derecruitment (R/D) is correlated with the lower and upper inflections points on the inflation and deflation limb of the whole-lung pressure-volume (P-V) curve.OBJECTIVETo determine whether individual alveolar recruitment/derecruitment (R/D) is correlated with the lower and upper inflections points on the inflation and deflation limb of the whole-lung pressure-volume (P-V) curve.Prospective experimental study in an animal research laboratory.DESIGN AND SETTINGProspective experimental study in an animal research laboratory.Five anesthetized rats subjected to saline-lavage lung injury.SUBJECTSFive anesthetized rats subjected to saline-lavage lung injury.Subpleural alveoli were filmed continuously using an in vivo microscope during the generation of a whole-lung P-V curve using the super syringe technique. Alveolar R/D was correlated to the calculated inflection points on both limbs of the P-V curve.INTERVENTIONSSubpleural alveoli were filmed continuously using an in vivo microscope during the generation of a whole-lung P-V curve using the super syringe technique. Alveolar R/D was correlated to the calculated inflection points on both limbs of the P-V curve.There was continual alveolar recruitment along the entire inflation limb in all animals. There was some correlation (R2=0.898) between the pressure below which microscopic derecruitment was observed and the upper inflection point on the deflation limb. No correlation was observed between this pressure and the lower inflection point on the inflation limb.MEASUREMENTS AND RESULTSThere was continual alveolar recruitment along the entire inflation limb in all animals. There was some correlation (R2=0.898) between the pressure below which microscopic derecruitment was observed and the upper inflection point on the deflation limb. No correlation was observed between this pressure and the lower inflection point on the inflation limb.In this physiological experiment in lungs with pure surfactant deactivation we found that individual alveolar recruitment measured by direct visualization was not correlated with the lower inflection point on inflation whereas alveolar derecruitment was correlated with alveolar derecruitment on deflation. These data suggest that inflection points on the P-V curve do not always represent a change in alveolar number.CONCLUSIONSIn this physiological experiment in lungs with pure surfactant deactivation we found that individual alveolar recruitment measured by direct visualization was not correlated with the lower inflection point on inflation whereas alveolar derecruitment was correlated with alveolar derecruitment on deflation. These data suggest that inflection points on the P-V curve do not always represent a change in alveolar number. |
| Author | Carney, David E Nieman, Gary F DiRocco, Joseph D |
| Author_xml | – sequence: 1 givenname: Joseph D surname: DiRocco fullname: DiRocco, Joseph D email: DiRoccoJ@upstate.edu organization: Department of Surgery, Upstate Medical University, 750 E Adams Street, 13210, Syracuse, NY, USA. DiRoccoJ@upstate.edu – sequence: 2 givenname: David E surname: Carney fullname: Carney, David E organization: Department of Surgery, Upstate Medical University, 750 E Adams Street, 13210, Syracuse, NY, USA – sequence: 3 givenname: Gary F surname: Nieman fullname: Nieman, Gary F organization: Department of Surgery, Upstate Medical University, 750 E Adams Street, 13210, Syracuse, NY, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17525844$$D View this record in MEDLINE/PubMed |
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| DOI | 10.1007/s00134-007-0629-8 |
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| Snippet | To determine whether individual alveolar recruitment/derecruitment (R/D) is correlated with the lower and upper inflections points on the inflation and... ObjectiveTo determine whether individual alveolar recruitment/derecruitment (R/D) is correlated with the lower and upper inflections points on the inflation... |
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| SubjectTerms | Alveoli Anesthesia Animals Correlation Hypotheses Inflection points Ketamine Lung Compliance - physiology Lung Volume Measurements Lungs Male Microscopy Ostomy Pulmonary Alveoli - cytology Pulmonary Alveoli - physiology Rats Rats, Sprague-Dawley Recruitment Ventilators |
| Title | Correlation between alveolar recruitment/derecruitment and inflection points on the pressure-volume curve |
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