Detection of Evolution and Adaptation Fingerprints in Metabolic Networks

Metabolic fluxes present an heterogeneity that can be exploited to construct metabolic backbones as reduced versions of metabolic networks. These backbones can be analysed to extract important biological information. In this chapter, the disparity filter is applied to two organisms, Escherichia coli...

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Bibliographic Details
Published inA Network-Based Approach to Cell Metabolism pp. 101 - 113
Main Author Güell, Oriol
Format Book Chapter
LanguageEnglish
Published Switzerland Springer International Publishing AG 2017
Springer International Publishing
SeriesSpringer Theses
Subjects
BIOCHEMICAL ENGINEERING
Life sciences: general issues
Physical chemistry
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ISBN9783319639994
3319639994
ISSN2190-5053
2190-5061
DOI10.1007/978-3-319-64000-6_5

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Summary:Metabolic fluxes present an heterogeneity that can be exploited to construct metabolic backbones as reduced versions of metabolic networks. These backbones can be analysed to extract important biological information. In this chapter, the disparity filter is applied to two organisms, Escherichia coli and Mycoplasma pneumoniae. Backbones offer information about long-term evolution since they contain the core of ancestral pathways related with energy obtainment optimized by evolution to maximize growth. At the same time, backbones unveil short-term adaptation capabilities to variable external stimuli.
ISBN:9783319639994
3319639994
ISSN:2190-5053
2190-5061
DOI:10.1007/978-3-319-64000-6_5