2012-2022年57558例患者过敏原特异性IgE阳性特征分析

目的 通过分析近十年间57558例患者过敏原特异性免疫球蛋白E(immunoglobulin E,IgE)分布情况,探讨其与年龄、性别、温度、相对湿度的关系,初步探索四川地区过敏原特异性IgE的流行特征,为四川地区过敏性疾病的预防和诊疗提供参考.方法 纳入2012年8月-2022年2月期间在四川大学华西医院进行过敏原检测(欧蒙,免疫印迹法)的患者共57558例,建立临床资料数据库,并收集同期温、湿度记录.并将阳性结果分为(±)微弱阳性、(+)阳性、(++)中等阳性和(+++)强阳性4个等级进行分析.应用SPSS 25.0进行卡方检验以对计数资料进行比较,采用Person相关检验对各类过敏原与温...

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Published inSichuan da xue xue bao. Journal of Sichuan University. Yi xue ban Vol. 55; no. 4; pp. 980 - 988
Main Authors 王雪安, 冯伟华, 黄卓春, 张君龙, 杨滨
Format Journal Article
LanguageChinese
English
Published 中国四川 四川大学华西医院 实验医学科(成都 610041) 20.07.2024
四川大学学报(医学版)编辑部
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ISSN1672-173X
DOI10.12182/20240760502

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Abstract 目的 通过分析近十年间57558例患者过敏原特异性免疫球蛋白E(immunoglobulin E,IgE)分布情况,探讨其与年龄、性别、温度、相对湿度的关系,初步探索四川地区过敏原特异性IgE的流行特征,为四川地区过敏性疾病的预防和诊疗提供参考.方法 纳入2012年8月-2022年2月期间在四川大学华西医院进行过敏原检测(欧蒙,免疫印迹法)的患者共57558例,建立临床资料数据库,并收集同期温、湿度记录.并将阳性结果分为(±)微弱阳性、(+)阳性、(++)中等阳性和(+++)强阳性4个等级进行分析.应用SPSS 25.0进行卡方检验以对计数资料进行比较,采用Person相关检验对各类过敏原与温度、相对湿度的相关关系进行分析,P<0.05为差异有统计学意义.使用GraphPad Prism 9.0.0对图片进行制作.结果 57558例样本的总体过敏原特异性IgE的阳性率为30.69%,阳性率前五的过敏原分别是尘螨组合1(14.46%)、蟹(6.67%)、黄豆(4.72%)、海鱼组合1(4.64%)和蟑螂(4.34%).鸡蛋白、花生、黄豆、牛奶、牛肉、羊肉、蟹、虾、海鱼组合1、蟑螂、葎草、普通豚草、艾蒿、树组合2、屋尘和霉菌组合1的微弱阳性(±)在其阳性结果中占比40%以上,猫毛、狗上皮的各阳性等级分布均匀(各25%左右),尘螨组合1的强阳性(+++)却在其阳性结果中占比最高(37.66%).花生、黄豆、蟹、虾、海鱼组合1、蟑螂、普通豚草、树组合、猫毛、狗上皮和尘螨组合1的阳性率有显著的性别差异.过敏原阳性率总体上随年龄增长呈现下降趋势,至少一种食物性过敏原阳性率在0~10岁年龄段人群中最高(36.18%),至少一种吸入性过敏原阳性率在11~20岁年龄段人群中最高(45.35%).牛奶的过敏原特异性IgE阳性率与相对湿度呈较强的负相关关系(r=-0.640,P<0.05),艾蒿与温度呈较强的负相关关系(r平均高温=-0.695,r平均低温=-0.692,P<0.05),霉菌组合1与相对湿度呈极强的正相关关系(r=0.704,P<0.05).结论 过敏原特异性IgE阳性率不仅与遗传因素相关,在人群中还有显著的性别、年龄特征,同时受到当地温、湿度变化的影响.
AbstractList 目的 通过分析近十年间57558例患者过敏原特异性免疫球蛋白E(immunoglobulin E,IgE)分布情况,探讨其与年龄、性别、温度、相对湿度的关系,初步探索四川地区过敏原特异性IgE的流行特征,为四川地区过敏性疾病的预防和诊疗提供参考.方法 纳入2012年8月-2022年2月期间在四川大学华西医院进行过敏原检测(欧蒙,免疫印迹法)的患者共57558例,建立临床资料数据库,并收集同期温、湿度记录.并将阳性结果分为(±)微弱阳性、(+)阳性、(++)中等阳性和(+++)强阳性4个等级进行分析.应用SPSS 25.0进行卡方检验以对计数资料进行比较,采用Person相关检验对各类过敏原与温度、相对湿度的相关关系进行分析,P<0.05为差异有统计学意义.使用GraphPad Prism 9.0.0对图片进行制作.结果 57558例样本的总体过敏原特异性IgE的阳性率为30.69%,阳性率前五的过敏原分别是尘螨组合1(14.46%)、蟹(6.67%)、黄豆(4.72%)、海鱼组合1(4.64%)和蟑螂(4.34%).鸡蛋白、花生、黄豆、牛奶、牛肉、羊肉、蟹、虾、海鱼组合1、蟑螂、葎草、普通豚草、艾蒿、树组合2、屋尘和霉菌组合1的微弱阳性(±)在其阳性结果中占比40%以上,猫毛、狗上皮的各阳性等级分布均匀(各25%左右),尘螨组合1的强阳性(+++)却在其阳性结果中占比最高(37.66%).花生、黄豆、蟹、虾、海鱼组合1、蟑螂、普通豚草、树组合、猫毛、狗上皮和尘螨组合1的阳性率有显著的性别差异.过敏原阳性率总体上随年龄增长呈现下降趋势,至少一种食物性过敏原阳性率在0~10岁年龄段人群中最高(36.18%),至少一种吸入性过敏原阳性率在11~20岁年龄段人群中最高(45.35%).牛奶的过敏原特异性IgE阳性率与相对湿度呈较强的负相关关系(r=-0.640,P<0.05),艾蒿与温度呈较强的负相关关系(r平均高温=-0.695,r平均低温=-0.692,P<0.05),霉菌组合1与相对湿度呈极强的正相关关系(r=0.704,P<0.05).结论 过敏原特异性IgE阳性率不仅与遗传因素相关,在人群中还有显著的性别、年龄特征,同时受到当地温、湿度变化的影响.
Abstract_FL Objective The study aims to preliminarily investigate the prevalence characteristics of allergen-specific immunoglobulin E(IgE)in 57558 patients over the past decade by examining its distribution in the province and exploring its associations with age,sex,temperature,and relative humidity,providing insights for the prevention and diagnosis of allergic diseases in the Sichuan region.Methods A retrospective analysis was conducted on a cohort of 57558 patients who underwent allergen testing(by means of EUROIMMUN immunoblotting method)at West China Hospital,Sichuan University between August 2012 and February 2022.The clinical data of these patients were collected to establish a comprehensive database,while the temperature and humidity records of the corresponding timeframe were gathered for further analysis.The positive results from the allergen tests were categorized into four levels,including weakly positive(±),positive(+),moderately positive(++),and strongly positive(+++).Statistical analyses were performed using SPSS 25.0,with Chi-square tests conducted to compare count data and Pearson's correlation tests done conducted to assess the relationships between different types of allergens and temperature/relative humidity.P<0.05 was applied to determine statistically significant differences.GraphPad Prism 9.0.0 was utilized to generate visual representations of the data.Results The overall positivity rate of allergen-specific IgE among the 57558 samples was 30.69%.The top five allergens that elicited positive results were dust mite mix 1(14.46%),crab(6.67%),soybean(4.72%),fish mix 1(4.64%),and cockroach(4.34%).Notably,weakly positive(±)results were predominant for allergens such as eggs,peanuts,soybeans,cow's milk,beef,mutton,crab,shrimp,fish mix 1,cockroach,humulus japonicus,ambrosia artemisifolia,artemisia vulgaris,tree mix 2,house dust,and mold mix 1,collectively constituting over 40%of the positive outcomes.In contrast,cat hair and dog dander exhibited an equal distribution of approximately 25%for each positive levels,while mite mix 1 demonstrated the highest proportion of strongly positive results(+++),accounting for 37.66%of all positive results.Sex disparities in positivity rates were evident for various allergens,with significant differences observed for peanut,soybean,crab,shrimp,fish mix 1,cockroach,ambrosia artemisifolia,tree mix 2,cat hair,dog dander,and mite mix 1.Furthermore,the study identified age-related trends in allergen positivity rates,with a general decline observed across most allergens with increasing age.The positive rate of at least one food allergen was highest in the 0-10 age group(36.18%),and the positive rate of at least one inhalation allergen was highest in the 11-20 age group(45.35%).Noteworthy correlations were observed between allergen-specific IgE positivity and environmental factors,including a strong negative correlation between cow's milk allergy and relative humidity(r=-0.640,P<0.05),a strong negative correlation of artemisia vulgaris sensitivity with temperature(rMean high temperature=-0.695,rMean low temperature=-0.692,P<0.05),and a very strong positive correlation of mold mix 1 sensitivity with relative humidity(r=0.704,P<0.05).Conclusion Allergen-specific IgE positivity is associated with genetic factors,demonstrates significant sex-and age-related characteristics in the population,and is influenced by changes in local temperature and relative humidity.
Author 黄卓春
张君龙
冯伟华
杨滨
王雪安
AuthorAffiliation 四川大学华西医院 实验医学科(成都 610041)
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Author_FL HUANG Zhuochun
WANG Xue'an
ZHANG Junlong
FENG Weihua
YANG Bin
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Keywords 温度
Relative humidity
Temperature
相对湿度
IgE
Sex
年龄
Age
过敏原
性别
Allergen
Language Chinese
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Snippet 目的 通过分析近十年间57558例患者过敏原特异性免疫球蛋白E(immunoglobulin E,IgE)分布情况,探讨其与年龄、性别、温度、相对湿度的关系,初步探索四川地区过敏原特异性IgE的流...
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Title 2012-2022年57558例患者过敏原特异性IgE阳性特征分析
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