免疫球蛋白A血管炎病因及发病机制的研究进展
免疫球蛋白A血管炎(immunoglobulin A vasculitis,IgAV),也称过敏性紫癜,病因及发病机制较为复杂,目前尚未完全阐明.最新研究表明,新型冠状病毒及相关疫苗、人乳头瘤疫苗及其他生物制剂等也可以诱发IgAV.大多研究认为,半乳糖缺陷型IgA1(galactose-deficient IgA1,Gd-IgA1)及含Gd-IgA1的免疫复合物形成在IgAV发病机制中起至关重要的作用.也有假设提出IgAV的发生与IgA1和抗内皮细胞抗体的结合有关.此外,遗传学也是IgAV研究的重点.该文综述IgAV病因的新进展,并总结Gd-IgA1、含Gd-IgA1的免疫复合物、抗内皮细胞抗...
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| Published in | Zhongguo dang dai er ke za zhi Vol. 25; no. 12; pp. 1287 - 1292 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Chinese English |
| Published |
湖南省长沙市湘雅路87号 中南大学湘雅医院内
南京中医药大学附属医院/南京中医药大学第一临床医学院,江苏南京 210029%南京中医药大学附属医院血液科,江苏南京 210029
15.12.2023
《中国当代儿科杂志》编辑部 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-8830 2096-9228 |
| DOI | 10.7499/j.issn.1008-8830.2307065 |
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| Abstract | 免疫球蛋白A血管炎(immunoglobulin A vasculitis,IgAV),也称过敏性紫癜,病因及发病机制较为复杂,目前尚未完全阐明.最新研究表明,新型冠状病毒及相关疫苗、人乳头瘤疫苗及其他生物制剂等也可以诱发IgAV.大多研究认为,半乳糖缺陷型IgA1(galactose-deficient IgA1,Gd-IgA1)及含Gd-IgA1的免疫复合物形成在IgAV发病机制中起至关重要的作用.也有假设提出IgAV的发生与IgA1和抗内皮细胞抗体的结合有关.此外,遗传学也是IgAV研究的重点.该文综述IgAV病因的新进展,并总结Gd-IgA1、含Gd-IgA1的免疫复合物、抗内皮细胞抗体和IgA1的结合物、T细胞免疫及遗传因素在IgAV发病机制中的作用. |
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| AbstractList | 免疫球蛋白A血管炎(immunoglobulin A vasculitis,IgAV),也称过敏性紫癜,病因及发病机制较为复杂,目前尚未完全阐明.最新研究表明,新型冠状病毒及相关疫苗、人乳头瘤疫苗及其他生物制剂等也可以诱发IgAV.大多研究认为,半乳糖缺陷型IgA1(galactose-deficient IgA1,Gd-IgA1)及含Gd-IgA1的免疫复合物形成在IgAV发病机制中起至关重要的作用.也有假设提出IgAV的发生与IgA1和抗内皮细胞抗体的结合有关.此外,遗传学也是IgAV研究的重点.该文综述IgAV病因的新进展,并总结Gd-IgA1、含Gd-IgA1的免疫复合物、抗内皮细胞抗体和IgA1的结合物、T细胞免疫及遗传因素在IgAV发病机制中的作用. 免疫球蛋白A血管炎（immunoglobulin A vasculitis, IgAV），也称过敏性紫癜，病因及发病机制较为复杂，目前尚未完全阐明。最新研究表明，新型冠状病毒及相关疫苗、人乳头瘤疫苗及其他生物制剂等也可以诱发IgAV。大多研究认为，半乳糖缺陷型IgA1（galactose-deficient IgA1, Gd-IgA1）及含Gd-IgA1的免疫复合物形成在IgAV发病机制中起至关重要的作用。也有假设提出IgAV的发生与IgA1和抗内皮细胞抗体的结合有关。此外，遗传学也是IgAV研究的重点。该文综述IgAV病因的新进展，并总结Gd-IgA1、含Gd-IgA1的免疫复合物、抗内皮细胞抗体和IgA1的结合物、T细胞免疫及遗传因素在IgAV发病机制中的作用。 |
| Abstract_FL | Immunoglobulin A vasculitis(IgAV),also known as Henoch-Sch?nlein purpura,has complex etiology and pathogenesis which have not been fully clarified.The latest research shows that SARS-CoV-2 and related vaccines,human papilloma vaccine,and certain biological agents can also induce IgAV.Most studies believe that the formation of galactose-deficient IgA1(Gd-IgA1)and Gd-IgA1-containing immune complex plays a crucial role in the pathogenesis of IgAV.It is hypothesized that the pathogenesis of IgAV is associated with the binding of IgA1 to anti-endothelial cell antibodies.In addition,genetics also constitutes a major focus of IgAV research.This article reviews the new advances in the etiology of IgAV and summarizes the role of Gd-IgA1,Gd-IgA1-containing immune complex,anti-endothelial antibody,IgA1 conjugates,T lymphocyte immunity,and genetic factors in the pathogenesis of IgAV. |
| Author | 朱学军 刘细细 热爱拉·加那提 |
| AuthorAffiliation | 南京中医药大学附属医院/南京中医药大学第一临床医学院,江苏南京 210029%南京中医药大学附属医院血液科,江苏南京 210029 |
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| Author_FL | ZHU Xue-Jun LIU Xi-Xi JIANATI Reaila |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. 版权所有 © 2023中国当代儿科杂志 © 2023 Chinese Journal of Contemporary Pediatrics |
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| Keywords | 发病机制 病因 Etiology Pathogenesis 免疫球蛋白A血管炎 Immunoglobulin A vasculitis 过敏性紫癜 Henoch-Sch?nlein purpura |
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| Notes | 热爱拉·加那提，女，硕士研究生 |
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| Publisher | 南京中医药大学附属医院/南京中医药大学第一临床医学院,江苏南京 210029%南京中医药大学附属医院血液科,江苏南京 210029 《中国当代儿科杂志》编辑部 |
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| Snippet | 免疫球蛋白A血管炎(immunoglobulin A vasculitis,IgAV),也称过敏性紫癜,病因及发病机制较为复杂,目前尚未完全阐明.最新研究表明,新型冠状病毒及相关疫苗、人乳头瘤疫苗及其... 免疫球蛋白A血管炎（immunoglobulin A vasculitis, IgAV），也称过敏性紫癜，病因及发病机制较为复杂，目前尚未完全阐明。最新研究表明，新型冠状病毒及相关疫苗、人乳头瘤... |
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| Title | 免疫球蛋白A血管炎病因及发病机制的研究进展 |
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