基因多态性与新生儿败血症的遗传易感性研究进展
新生儿败血症是常见的感染性疾病,病情严重,病死率高.其发病机制复杂,缺乏特异性表现,培养阳性率低,早期诊断和个体化治疗仍然是临床医生面临的挑战.对双胞胎的流行病学研究表明,遗传因素与新生儿败血症存在关联.基因多态性与其易感性、病情发展和预后密切相关.该文就新生儿败血症相关的白细胞介素、肿瘤坏死因子、Toll样受体、NOD样受体、CD14、髓系细胞触发受体1、甘露糖结合凝集素和其他免疫蛋白基因多态性进行综述,以期促进该疾病的精准医疗....
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| Published in | Zhongguo dang dai er ke za zhi Vol. 26; no. 8; pp. 879 - 886 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | Chinese English |
| Published |
湖南省长沙市湘雅路87号 中南大学湘雅医院内
天津市儿科研究所/天津市儿童出生缺陷防治重点实验室,天津 300134
15.08.2024
天津市儿童医院/天津大学儿童医院,天津 300134 天津医科大学研究生院,天津 300070%天津医科大学研究生院,天津 300070 天津市儿童医院/天津大学儿童医院龙岩院区新生儿科,天津 300134 《中国当代儿科杂志》编辑部 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-8830 2096-9228 |
| DOI | 10.7499/j.issn.1008-8830.2401065 |
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| Abstract | 新生儿败血症是常见的感染性疾病,病情严重,病死率高.其发病机制复杂,缺乏特异性表现,培养阳性率低,早期诊断和个体化治疗仍然是临床医生面临的挑战.对双胞胎的流行病学研究表明,遗传因素与新生儿败血症存在关联.基因多态性与其易感性、病情发展和预后密切相关.该文就新生儿败血症相关的白细胞介素、肿瘤坏死因子、Toll样受体、NOD样受体、CD14、髓系细胞触发受体1、甘露糖结合凝集素和其他免疫蛋白基因多态性进行综述,以期促进该疾病的精准医疗. |
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| AbstractList | 新生儿败血症是常见的感染性疾病,病情严重,病死率高.其发病机制复杂,缺乏特异性表现,培养阳性率低,早期诊断和个体化治疗仍然是临床医生面临的挑战.对双胞胎的流行病学研究表明,遗传因素与新生儿败血症存在关联.基因多态性与其易感性、病情发展和预后密切相关.该文就新生儿败血症相关的白细胞介素、肿瘤坏死因子、Toll样受体、NOD样受体、CD14、髓系细胞触发受体1、甘露糖结合凝集素和其他免疫蛋白基因多态性进行综述,以期促进该疾病的精准医疗. 新生儿败血症是常见的感染性疾病，病情严重，病死率高。其发病机制复杂，缺乏特异性表现，培养阳性率低，早期诊断和个体化治疗仍然是临床医生面临的挑战。对双胞胎的流行病学研究表明，遗传因素与新生儿败血症存在关联。基因多态性与其易感性、病情发展和预后密切相关。该文就新生儿败血症相关的白细胞介素、肿瘤坏死因子、Toll样受体、NOD样受体、CD14、髓系细胞触发受体1、甘露糖结合凝集素和其他免疫蛋白基因多态性进行综述，以期促进该疾病的精准医疗。 |
| Abstract_FL | Neonatal sepsis is a common and severe infectious disease with a high mortality rate.Its pathogenesis is complex,lacks specific manifestations,and has a low positive culture rate,making early diagnosis and personalized treatment still a challenge for clinicians.Epidemiological studies on twins have shown that genetic factors are associated with neonatal sepsis.Gene polymorphisms are closely related to susceptibility,disease development,and prognosis.This article provides a review of gene polymorphisms related to neonatal sepsis,including interleukins,tumor necrosis factor,Toll-like receptors,NOD-like receptors,CD14,triggering receptor expressed on myeloid cells-1,mannose-binding lectin,and other immune proteins,aiming to promote precision medicine for this disease. |
| Author | 舒剑波 刘洋 高静 |
| AuthorAffiliation | 天津市儿童医院/天津大学儿童医院龙岩院区新生儿科,天津 300134;天津医科大学研究生院,天津 300070%天津医科大学研究生院,天津 300070;天津市儿童医院/天津大学儿童医院,天津 300134;天津市儿科研究所/天津市儿童出生缺陷防治重点实验室,天津 300134 |
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| Author_FL | LIU Yang SHU Jian-Bo GAO Jing |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. 版权所有 © 2024中国当代儿科杂志 © 2024 Chinese Journal of Contemporary Pediatrics |
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| Keywords | 基因多态性 Neonate Genetic susceptibility 单核苷酸多态性 遗传易感性 Sepsis Single nucleotide polymorphism 新生儿 Gene polymorphism 败血症 |
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| Publisher | 天津市儿科研究所/天津市儿童出生缺陷防治重点实验室,天津 300134 天津市儿童医院/天津大学儿童医院,天津 300134 天津医科大学研究生院,天津 300070%天津医科大学研究生院,天津 300070 天津市儿童医院/天津大学儿童医院龙岩院区新生儿科,天津 300134 《中国当代儿科杂志》编辑部 |
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| Snippet | 新生儿败血症是常见的感染性疾病,病情严重,病死率高.其发病机制复杂,缺乏特异性表现,培养阳性率低,早期诊断和个体化治疗仍然是临床医生面临的挑战.对双胞胎的流行病学研究... 新生儿败血症是常见的感染性疾病，病情严重，病死率高。其发病机制复杂，缺乏特异性表现，培养阳性率低，早期诊断和个体化治疗仍然是临床医生面临的挑战。对双胞胎的流行病... |
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| Title | 基因多态性与新生儿败血症的遗传易感性研究进展 |
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