中药活性成分调控糖代谢抗胆管癌的分子机制
胆管癌是一种高度异质性的肿瘤，其发病隐匿、病情凶险、恶性程度高、预后极差。葡萄糖是胆管癌增殖和转移的主要能量来源，胆管癌细胞在快速增殖过程中其糖代谢途径会被重新编辑，产生大量能量以满足自身需求。中医药在胆管癌治疗中具有独特优势，中药活性成分已被证明可以通过调控糖代谢抑制胆管癌的发生和发展。本文对胆管癌中的糖代谢特点和中药活性成分调控糖代谢抗胆管癌进行综述，为胆管癌的治疗提供新思路。...
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| Published in | Linchuang gandanbing zazhi Vol. 40; no. 8; pp. 1704 - 1708 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.08.2024
河南中医药大学 第三临床医学院,郑州 450046%河南中医药大学 医学院,郑州 450046%河南中医药大学第三附属医院肿瘤科,郑州 450046 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.12449/JCH240832 |
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| Abstract | 胆管癌是一种高度异质性的肿瘤，其发病隐匿、病情凶险、恶性程度高、预后极差。葡萄糖是胆管癌增殖和转移的主要能量来源，胆管癌细胞在快速增殖过程中其糖代谢途径会被重新编辑，产生大量能量以满足自身需求。中医药在胆管癌治疗中具有独特优势，中药活性成分已被证明可以通过调控糖代谢抑制胆管癌的发生和发展。本文对胆管癌中的糖代谢特点和中药活性成分调控糖代谢抗胆管癌进行综述，为胆管癌的治疗提供新思路。 |
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| AbstractList | 胆管癌是一种高度异质性的肿瘤,其发病隐匿、病情凶险、恶性程度高、预后极差.葡萄糖是胆管癌增殖和转移的主要能量来源,胆管癌细胞在快速增殖过程中其糖代谢途径会被重新编辑,产生大量能量以满足自身需求.中医药在胆管癌治疗中具有独特优势,中药活性成分已被证明可以通过调控糖代谢抑制胆管癌的发生和发展.本文对胆管癌中的糖代谢特点和中药活性成分调控糖代谢抗胆管癌进行综述,为胆管癌的治疗提供新思路. 胆管癌是一种高度异质性的肿瘤，其发病隐匿、病情凶险、恶性程度高、预后极差。葡萄糖是胆管癌增殖和转移的主要能量来源，胆管癌细胞在快速增殖过程中其糖代谢途径会被重新编辑，产生大量能量以满足自身需求。中医药在胆管癌治疗中具有独特优势，中药活性成分已被证明可以通过调控糖代谢抑制胆管癌的发生和发展。本文对胆管癌中的糖代谢特点和中药活性成分调控糖代谢抗胆管癌进行综述，为胆管癌的治疗提供新思路。 |
| Abstract_FL | Cholangiocarcinoma is a highly heterogeneous tumor with an insidious onset,severe conditions,a high degree of malignancy,and an extremely poor prognosis.Glucose is a major energy source for the proliferation and metastasis of cholangiocarcinoma,and the glucose metabolism pathway of cholangiocarcinoma cells will be re-edited in the process of rapid proliferation to produce a large amount of energy for their own needs.Traditional Chinese medicine has unique advantages in the treatment of cholangiocarcinoma,and studies have shown that the active components of traditional Chinese medicine can inhibit the development and progression of cholangiocarcinoma by regulating glucose metabolism.This article reviews the characteristics of glucose metabolism in cholangiocarcinoma and the role of the active components of traditional Chinese medicine in regulating glucose metabolism against cholangiocarcinoma,in order to provide new ideas for the treatment of cholangiocarcinoma. |
| Author | 王祥麒 赵方言 尹怡 李姗 |
| AuthorAffiliation | 河南中医药大学 第三临床医学院,郑州 450046%河南中医药大学 医学院,郑州 450046%河南中医药大学第三附属医院肿瘤科,郑州 450046 |
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| Author_FL | LI Shan WANG Xiangqi YIN Yi ZHAO Fangyan |
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| DOI | 10.12449/JCH240832 |
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| Keywords | 碳水化合物代谢 药理作用分子作用机制(中药) Molecular Mechanisms of Pharmacological Action(TCD) Traditional Chinese Drugs Carbohydrate Metabolism Bile Duct Neoplasms 胆管肿瘤 中药 |
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| Snippet | 胆管癌是一种高度异质性的肿瘤，其发病隐匿、病情凶险、恶性程度高、预后极差。葡萄糖是胆管癌增殖和转移的主要能量来源，胆管癌细胞在快速增殖过程中其糖代谢途径会被重新编... 胆管癌是一种高度异质性的肿瘤,其发病隐匿、病情凶险、恶性程度高、预后极差.葡萄糖是胆管癌增殖和转移的主要能量来源,胆管癌细胞在快速增殖过程中其糖代谢途径会被重新编辑,... |
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| Title | 中药活性成分调控糖代谢抗胆管癌的分子机制 |
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