线粒体功能障碍与肝细胞癌的关系
肝细胞癌(HCC)是一种发病率高、早诊率低、预后差的肿瘤，其发生与发展涉及多方面因素。线粒体是细胞的“能量工厂”，是体内活性氧自由基产生的主要部位之一，并参与调控细胞凋亡，是一种重要的细胞器。在HCC发生、发展过程中，线粒体膜、氧化呼吸链、线粒体动力学、线粒体DNA、线粒体钙稳态等均发生不同程度的变化，且这种改变会影响HCC的进展。系统阐述线粒体与HCC的关系，为HCC的诊治提供新方向。...
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| Published in | Linchuang gandanbing zazhi Vol. 38; no. 6; pp. 1436 - 1439 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.06.2022
中国人民解放军总医院第五医学中心肝脏肿瘤诊疗与研究中心,北京100039%贵州医科大学附属医院肝胆外科,贵阳550004%中国人民解放军总医院第五医学中心肝脏肿瘤诊疗与研究中心,北京100039 贵州医科大学附属医院肝胆外科,贵阳550004 |
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| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2022.06.045 |
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| Abstract | 肝细胞癌(HCC)是一种发病率高、早诊率低、预后差的肿瘤，其发生与发展涉及多方面因素。线粒体是细胞的“能量工厂”，是体内活性氧自由基产生的主要部位之一，并参与调控细胞凋亡，是一种重要的细胞器。在HCC发生、发展过程中，线粒体膜、氧化呼吸链、线粒体动力学、线粒体DNA、线粒体钙稳态等均发生不同程度的变化，且这种改变会影响HCC的进展。系统阐述线粒体与HCC的关系，为HCC的诊治提供新方向。 |
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| AbstractList | 肝细胞癌(HCC)是一种发病率高、早诊率低、预后差的肿瘤，其发生与发展涉及多方面因素。线粒体是细胞的“能量工厂”，是体内活性氧自由基产生的主要部位之一，并参与调控细胞凋亡，是一种重要的细胞器。在HCC发生、发展过程中，线粒体膜、氧化呼吸链、线粒体动力学、线粒体DNA、线粒体钙稳态等均发生不同程度的变化，且这种改变会影响HCC的进展。系统阐述线粒体与HCC的关系，为HCC的诊治提供新方向。 肝细胞癌(HCC)是一种发病率高、早诊率低、预后差的肿瘤,其发生与发展涉及多方面因素.线粒体是细胞的"能量工厂",是体内活性氧自由基产生的主要部位之一,并参与调控细胞凋亡,是一种重要的细胞器.在HCC发生、发展过程中,线粒体膜、氧化呼吸链、线粒体动力学、线粒体DNA、线粒体钙稳态等均发生不同程度的变化,且这种改变会影响HCC的进展.系统阐述线粒体与HCC的关系,为HCC的诊治提供新方向. |
| Author | 陆荫英 贾晓东 高小强 左石 |
| AuthorAffiliation | 贵州医科大学附属医院肝胆外科,贵阳550004;中国人民解放军总医院第五医学中心肝脏肿瘤诊疗与研究中心,北京100039%贵州医科大学附属医院肝胆外科,贵阳550004%中国人民解放军总医院第五医学中心肝脏肿瘤诊疗与研究中心,北京100039 |
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| Snippet | 肝细胞癌(HCC)是一种发病率高、早诊率低、预后差的肿瘤，其发生与发展涉及多方面因素。线粒体是细胞的“能量工厂”，是体内活性氧自由基产生的主要部位之一，并参与调控细胞凋... 肝细胞癌(HCC)是一种发病率高、早诊率低、预后差的肿瘤,其发生与发展涉及多方面因素.线粒体是细胞的"能量工厂",是体内活性氧自由基产生的主要部位之一,并参与调控细胞凋亡,... |
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