HBV介导的肝星状细胞和天然免疫细胞的相互作用

肝脏非实质细胞在HBV相关的肝脏疾病中发挥着至关重要的作用,而肝星状细胞(HSC)的激活以及与肝内细胞之间的相互作用是导致肝纤维化的主要原因。主要介绍了HBV诱导的肝脏炎症以及天然免疫细胞与HSC的相互作用,简述了HBV作用下单核/巨噬细胞和自然杀伤细胞(NK细胞)对HSC的激活和杀伤作用以及HSC的肝脏免疫调节作用。...

Full description

Saved in:
Bibliographic Details
Published inLinchuang gandanbing zazhi Vol. 36; no. 4; pp. 891 - 894
Main Authors 杨苗苗, 邬志惠, 涂正坤
Format Journal Article
LanguageChinese
Published Changchun Journal of Clinical Hepatology 01.04.2020
吉林大学第一医院转化医学研究院,长春,130021
Subjects
单核巨噬细胞系统
肝星状细胞
肝硬化
乙型肝炎病毒
自然杀伤细胞
Online AccessGet full text
ISSN1001-5256
2097-3497
DOI10.3969/j.issn.1001-5256.2020.04.040

Cover

Abstract 肝脏非实质细胞在HBV相关的肝脏疾病中发挥着至关重要的作用,而肝星状细胞(HSC)的激活以及与肝内细胞之间的相互作用是导致肝纤维化的主要原因。主要介绍了HBV诱导的肝脏炎症以及天然免疫细胞与HSC的相互作用,简述了HBV作用下单核/巨噬细胞和自然杀伤细胞(NK细胞)对HSC的激活和杀伤作用以及HSC的肝脏免疫调节作用。
AbstractList R512.62; 肝脏非实质细胞在HBV相关的肝脏疾病中发挥着至关重要的作用,而肝星状细胞(HSC)的激活以及与肝内细胞之间的相互作用是导致肝纤维化的主要原因.主要介绍了HBV诱导的肝脏炎症以及天然免疫细胞与HSC的相互作用,简述了HBV作用下单核/巨噬细胞和自然杀伤细胞(NK细胞)对HSC的激活和杀伤作用以及HSC的肝脏免疫调节作用.
肝脏非实质细胞在HBV相关的肝脏疾病中发挥着至关重要的作用,而肝星状细胞(HSC)的激活以及与肝内细胞之间的相互作用是导致肝纤维化的主要原因。主要介绍了HBV诱导的肝脏炎症以及天然免疫细胞与HSC的相互作用,简述了HBV作用下单核/巨噬细胞和自然杀伤细胞(NK细胞)对HSC的激活和杀伤作用以及HSC的肝脏免疫调节作用。
Author 杨苗苗
邬志惠
涂正坤
AuthorAffiliation 吉林大学第一医院转化医学研究院,长春,130021
AuthorAffiliation_xml – name: 吉林大学第一医院转化医学研究院,长春,130021
Author_FL YANG Miaomiao
TU Zhengkun
WU Zhihui
Author_FL_xml – sequence: 1
  fullname: YANG Miaomiao
– sequence: 2
  fullname: WU Zhihui
– sequence: 3
  fullname: TU Zhengkun
Author_xml – sequence: 1
  fullname: 杨苗苗
– sequence: 2
  fullname: 邬志惠
– sequence: 3
  fullname: 涂正坤
BookMark eNpFz7tKA0EUBuBBFIwxT6GFza5nbjs7lWhQIwRs1DbMbGZDQtjErEFIqdHCSxNExGtjoVjYBTH6Nlknj-FKROHAgcPHf_hn0GTUiAxC8xhcKj25WHOrcRy5GAA7nHDPJUDABZYOTKAMASkcyqSYRJk_M41ycVzVwDH1JONeBi0VVnaGg9Pk9cNed0cHd19XD_akbwfHo8P7pHeWPD7bbj85OreXL-NjyuzN2_C9N_y8tRdPs2gqVPXY5H53Fm2vrW7lC05xc30jv1x0mphi38GECUl85XvGACkDECKoLoMOQw6CEmKUEsowjSkPtDA48DXRAYUwZJhDQLNoYZy7r6JQRZVSrdFuRenHUj2olHWn89M-bc78lM6NabPV2G2beO_fUsIAC5Ae0G8fc3HP
ClassificationCodes R512.62
ContentType Journal Article
Copyright 2020. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: 2020. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 3V.
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
M0S
M1P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
2B.
4A8
92I
93N
PSX
TCJ
DOI 10.3969/j.issn.1001-5256.2020.04.040
DatabaseName ProQuest Central (Corporate)
Health & Medical Collection (Proquest)
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni Edition)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
Medical Database
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitle Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
DatabaseTitleList
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
DocumentTitle_FL Hepatitis B virus-mediated interaction between hepatic stellate cells and innate immune cells
EISSN 2097-3497
EndPage 894
ExternalDocumentID lcgdbzz202004048
GrantInformation_xml – fundername: 国家自然科学基金项目
  funderid: (81373143,81571535)
GroupedDBID -05
3V.
5XA
5XF
7X7
7XB
88E
8FI
8FJ
8FK
92F
92I
ABDBF
ABJNI
ABUWG
ACGFS
ACUHS
AFKRA
ALMA_UNASSIGNED_HOLDINGS
AZQEC
BENPR
CCEZO
CCPQU
CIEJG
CW9
DWQXO
EAD
EAP
EOJEC
ESX
FYUFA
K9.
M1P
OBODZ
OK1
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
RNS
TCJ
TGQ
U1G
U5O
2B.
4A8
93N
IPNFZ
PSX
RIG
ID FETCH-LOGICAL-p1318-1247928a86ee02d002273bd0bff507322eaa7ae4b135cb7e1c8b2bc30ff4150c3
IEDL.DBID 7X7
ISSN 1001-5256
IngestDate Thu May 29 04:06:09 EDT 2025
Tue Sep 02 12:17:46 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords 单核巨噬细胞系统
肝星状细胞
肝硬化
乙型肝炎病毒
自然杀伤细胞
Language Chinese
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-p1318-1247928a86ee02d002273bd0bff507322eaa7ae4b135cb7e1c8b2bc30ff4150c3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
OpenAccessLink https://www.proquest.com/docview/3240170960?pq-origsite=%requestingapplication%
PQID 3240170960
PQPubID 7350069
PageCount 4
ParticipantIDs wanfang_journals_lcgdbzz202004048
proquest_journals_3240170960
PublicationCentury 2000
PublicationDate 2020-04-01
PublicationDateYYYYMMDD 2020-04-01
PublicationDate_xml – month: 04
  year: 2020
  text: 2020-04-01
  day: 01
PublicationDecade 2020
PublicationPlace Changchun
PublicationPlace_xml – name: Changchun
PublicationTitle Linchuang gandanbing zazhi
PublicationTitle_FL Journal of Clinical Hepatology
PublicationYear 2020
Publisher Journal of Clinical Hepatology
吉林大学第一医院转化医学研究院,长春,130021
Publisher_xml – name: Journal of Clinical Hepatology
– name: 吉林大学第一医院转化医学研究院,长春,130021
SSID ssib051369456
ssib061082477
ssj0041983
ssib001103858
ssib053243598
ssib002264326
ssib038074677
Score 2.2312546
SecondaryResourceType review_article
Snippet 肝脏非实质细胞在HBV相关的肝脏疾病中发挥着至关重要的作用,而肝星状细胞(HSC)的激活以及与肝内细胞之间的相互作用是导致肝纤维化的主要原因。主要介绍了HBV诱导的肝脏炎症以及天然免疫细胞与HSC的相互作用,简述了HBV作用下单核/巨噬细胞和自然杀伤细胞(NK细胞)对HSC的激活和杀伤作用以及HSC的肝脏免疫调节作用。
R512.62;...
SourceID wanfang
proquest
SourceType Aggregation Database
StartPage 891
Title HBV介导的肝星状细胞和天然免疫细胞的相互作用
URI https://www.proquest.com/docview/3240170960
https://d.wanfangdata.com.cn/periodical/lcgdbzz202004048
Volume 36
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1JS8NAFB7UongRV1xqqeA1mkkmyeQkrVqKUBFR6U1mkokiUneEHt0OLhcREdeLB8WDNxGXf9Maf4ZvktTWi5eEZIYJvLzlezNvvkFo0ANFwcwVismoUIhnc4UzuBiCukGEMqncjZybNLOzZCJv5KMJt42orLLiEwNH7a44co58WBLHYUsC7pHVNUWeGiVXV6MjNOpRDANUkVpt5avhFGP1D1eL3DRaA1ck1zqpoXMzsG7apMotY8A3JcFd5RmQBtWCfZuhpyeQsIcF_JCSG4AdmtCgzIJt0x5eCmx46LcJMlFNDUhVifoHzDZus4LHCgs1US3TiloiOJpMhfrThuqKi-2oKRctuHegkWx6rvR-VH7-8C_3vnduvi7u_MMX__3ge_e2fHpcvn_0917K-yf--VP4Err5V6-lt9PS57V_9tCJZjPjM6NZJTpzQVnFYN4KhHvL1iijphCq5gYMgzp3Ve55gBzB-gVjFhOEY91wuCWwQ7nGHV31PIACqqN3oYbCSkF0oyRzACq4nBsUYI_tMJtAKoM9GAMgp0FFD4pXxDAfGc7GfPU396CBSDTV1mVnweXFopQlyJHQ3v-H6EPNsmtYaBNHDZvrW6IfMMQmTwSKkkCxVHosnYF7enxyavoHkADPLg
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQSQMmFMPElFRds0SLVF2TNMsk3aREIGGaapECrqHMLEC7kX39zDxCTbwiTCOYGPbB9sKAllXCykRwQZ2SnwwaI9cHHRxnaA5qcNsXFOqCbo0Cza7CrtBIhF6tkGILPmIMurHDO7WyHNiFK7b1dAHGt6qRkZtriLOHLvSWAd0CQ2CC1gVWcOaWRhaJFmapqQZGKeAz9YyTUgyS0tKAbSVgek9NTDRPTDVJMjQ2TU4yTzVMtkgySko2NkhLA1Z-BsnGQHOZGViBzQ5jYK5idXL1CwhCNEgMDVBOiwFtW0VqMIFOezdBOlDO1NDYzNIEcbqNKdDXoCP2YHxgW8fCCLxzFFLXmBhaWkC2EBgYAruUpmYcDCqgfrilmaV-FrgU0YNLAfvCRgbgY11NDFCa0-zliXlpiXnpSPWqmyADP7RBrOAIScFCDExVGcIMHL7QKX8RBnsPp7Anu7ufrt_zfFbLi6a5z2bMf9617fnuthfN855O6nm6ZOXzlm1PW3ufT1sNEQQqez57x5Ndk57snfN8ygpRhlCaxIcYA0tefl6qBINCYjKwsZKSlGRqAWx4WSYnWpoAO1OGaUAzgI1eU4tUSQYZWDDEQ7NucTwioUkyKEKDBiGbk5yeklRVBQpLYDiaWEjhN0KegdMjxNcn3sfTz1uagQukDbLsR4aBpaSoNFUW2KIpSZKDJhsFhgRap1QAZOsPEQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=HBV%E4%BB%8B%E5%AF%BC%E7%9A%84%E8%82%9D%E6%98%9F%E7%8A%B6%E7%BB%86%E8%83%9E%E5%92%8C%E5%A4%A9%E7%84%B6%E5%85%8D%E7%96%AB%E7%BB%86%E8%83%9E%E7%9A%84%E7%9B%B8%E4%BA%92%E4%BD%9C%E7%94%A8&rft.jtitle=%E4%B8%B4%E5%BA%8A%E8%82%9D%E8%83%86%E7%97%85%E6%9D%82%E5%BF%97&rft.au=%E6%9D%A8%E8%8B%97%E8%8B%97&rft.au=%E9%82%AC%E5%BF%97%E6%83%A0&rft.au=%E6%B6%82%E6%AD%A3%E5%9D%A4&rft.date=2020-04-01&rft.pub=%E5%90%89%E6%9E%97%E5%A4%A7%E5%AD%A6%E7%AC%AC%E4%B8%80%E5%8C%BB%E9%99%A2%E8%BD%AC%E5%8C%96%E5%8C%BB%E5%AD%A6%E7%A0%94%E7%A9%B6%E9%99%A2%2C%E9%95%BF%E6%98%A5%2C130021&rft.issn=1001-5256&rft.volume=36&rft.issue=4&rft.spage=891&rft.epage=894&rft_id=info:doi/10.3969%2Fj.issn.1001-5256.2020.04.040&rft.externalDocID=lcgdbzz202004048
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Flcgdbzz%2Flcgdbzz.jpg