空腹血糖水平与胆石症发病风险的关系
目的探讨空腹血糖与胆石症发病风险的关系。方法选取开滦研究中在2006-2007年度健康体检中进行空腹血糖及肝、胆超声检查的87 513例观察对象,根据血糖检测结果,将观察对象分为血糖正常组 (n=73 456) ﹑空腹血糖受损组 (n=7165) 和糖尿病组 (n=6892) 。采用log-rank检验比较不同分组间胆石症的累积发病率;采用Cox比例风险模型分析不同空腹血糖水平分组对新发胆石症的影响,计算风险比 (HR) 和95%可信区间 (95%CI) ;采用分层分析比较在不同性别﹑血脂水平和BMI人群中不同空腹血糖分组间胆石症发病风险。正态分布的计量资料多组间比较采用单因素方差分析;偏态分...
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| Published in | Linchuang gandanbing zazhi Vol. 35; no. 11; pp. 2517 - 2522 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Chinese |
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Changchun
Journal of Clinical Hepatology
01.11.2019
华北理工大学研究生院,河北唐山063000 华北理工大学附属开滦总医院肝胆外科,河北唐山063000%华北理工大学附属开滦总医院肝胆外科,河北唐山,063000 |
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| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2019.11.025 |
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| Abstract | 目的探讨空腹血糖与胆石症发病风险的关系。方法选取开滦研究中在2006-2007年度健康体检中进行空腹血糖及肝、胆超声检查的87 513例观察对象,根据血糖检测结果,将观察对象分为血糖正常组 (n=73 456) ﹑空腹血糖受损组 (n=7165) 和糖尿病组 (n=6892) 。采用log-rank检验比较不同分组间胆石症的累积发病率;采用Cox比例风险模型分析不同空腹血糖水平分组对新发胆石症的影响,计算风险比 (HR) 和95%可信区间 (95%CI) ;采用分层分析比较在不同性别﹑血脂水平和BMI人群中不同空腹血糖分组间胆石症发病风险。正态分布的计量资料多组间比较采用单因素方差分析;偏态分布的计量资料多组间比较采用Krustal-willis H秩和检验。分类资料组间差异比较采用χ2检验。结果血糖正常组、空腹血糖受损组、糖尿病组的胆石症累积发病率分别为10. 91%、12. 17%和18. 86%,三组胆石症累积发病率差异有统计学意义 (χ2=27. 94,P <0. 05) 。在Cox比例风险模型分析中,连续校正其他因素后,与血糖正常组相比,空腹血糖受损... |
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| AbstractList | 目的探讨空腹血糖与胆石症发病风险的关系。方法选取开滦研究中在2006-2007年度健康体检中进行空腹血糖及肝、胆超声检查的87 513例观察对象,根据血糖检测结果,将观察对象分为血糖正常组 (n=73 456) ﹑空腹血糖受损组 (n=7165) 和糖尿病组 (n=6892) 。采用log-rank检验比较不同分组间胆石症的累积发病率;采用Cox比例风险模型分析不同空腹血糖水平分组对新发胆石症的影响,计算风险比 (HR) 和95%可信区间 (95%CI) ;采用分层分析比较在不同性别﹑血脂水平和BMI人群中不同空腹血糖分组间胆石症发病风险。正态分布的计量资料多组间比较采用单因素方差分析;偏态分布的计量资料多组间比较采用Krustal-willis H秩和检验。分类资料组间差异比较采用χ2检验。结果血糖正常组、空腹血糖受损组、糖尿病组的胆石症累积发病率分别为10. 91%、12. 17%和18. 86%,三组胆石症累积发病率差异有统计学意义 (χ2=27. 94,P <0. 05) 。在Cox比例风险模型分析中,连续校正其他因素后,与血糖正常组相比,空腹血糖受损... R575.62; 目的 探讨空腹血糖与胆石症发病风险的关系.方法 选取开滦研究中在2006-2007年度健康体检中进行空腹血糖及肝、胆超声检查的87513例观察对象,根据血糖检测结果,将观察对象分为血糖正常组(n=73456)、空腹血糖受损组(n=7165)和糖尿病组(n=6892).采用log-rank检验比较不同分组间胆石症的累积发病率;采用Cox比例风险模型分析不同空腹血糖水平分组对新发胆石症的影响,计算风险比(HR)和95％可信区间(95％CI);采用分层分析比较在不同性别、血脂水平和BMI人群中不同空腹血糖分组间胆石症发病风险.正态分布的计量资料多组间比较采用单因素方差分析;偏态分布的计量资料多组间比较采用Krustal-willis H秩和检验.分类资料组间差异比较采用χ2检验.结果 血糖正常组、空腹血糖受损组、糖尿病组的胆石症累积发病率分别为10.91％、12.17％和18.86％,三组胆石症累积发病率差异有统计学意义(χ2=27.94,P<0.05).在Cox比例风险模型分析中,连续校正其他因素后,与血糖正常组相比,空腹血糖受损组新发胆石症风险为0.97(95％CI:0.85～1.11)(P=0.587)、糖尿病组新发胆石症风险为1.15(95％CI:1.01～1.30)(P=0.019).进一步分层分析发现,在男性(HR=1.16,95％CI:1.01～1.33,P=0.043)、血脂正常(HR=1.22,95％CI:1.01～1.49,P=0.044)、BMI超重(HR=1.16,95％CI:1.01～1.35,P=0.048)人群中糖尿病是新发胆石症的危险因素.结论 糖尿病会增加新发胆石症的风险.在男性、血脂正常、BMI超重人群中糖尿病是新发胆石症发病的独立危险因素. |
| Author | 王一鸣 曹立瀛 魏垚臣 刘四清 梁明杨 孙苗苗 崔皓哲 |
| AuthorAffiliation | 华北理工大学研究生院,河北唐山063000;华北理工大学附属开滦总医院肝胆外科,河北唐山063000%华北理工大学附属开滦总医院肝胆外科,河北唐山,063000 |
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| Keywords | 糖尿病 胆结石 危险因素 血糖 |
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| Publisher | Journal of Clinical Hepatology 华北理工大学研究生院,河北唐山063000 华北理工大学附属开滦总医院肝胆外科,河北唐山063000%华北理工大学附属开滦总医院肝胆外科,河北唐山,063000 |
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| Snippet | 目的探讨空腹血糖与胆石症发病风险的关系。方法选取开滦研究中在2006-2007年度健康体检中进行空腹血糖及肝、胆超声检查的87 513例观察对象,根据血糖检测结果,将观察对象分为... R575.62; 目的 探讨空腹血糖与胆石症发病风险的关系.方法 选取开滦研究中在2006-2007年度健康体检中进行空腹血糖及肝、胆超声检查的87513例观察对象,根据血糖检测结果,将观... |
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| Title | 空腹血糖水平与胆石症发病风险的关系 |
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