新型冠状病毒感染抗病毒药物引起肝损伤的发生机制
药物性肝损伤是药物使用过程中因药物本身和/或其代谢产物，或由于特殊体质对药物的超敏感性或耐受性降低所导致。在近三年抗击新型冠状病毒感染 (COVID-19) 的诊治过程中，抗病毒药物起到了非常重要的作用，但国内外关于抗COVID-19药物引起肝损伤的报道较多，且其导致肝损伤的发生机制尚未明确。本文对COVID-19抗病毒药物的种类及其引起肝损伤机制的相关研究进展作一综述，旨在促进抗病毒药物的合理使用。...
Saved in:
| Published in | Linchuang gandanbing zazhi Vol. 40; no. 2; pp. 402 - 407 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.02.2024
遵义医科大学附属医院消化内科, 贵州 遵义 563000 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.12449/JCH240230 |
Cover
| Abstract | 药物性肝损伤是药物使用过程中因药物本身和/或其代谢产物，或由于特殊体质对药物的超敏感性或耐受性降低所导致。在近三年抗击新型冠状病毒感染 (COVID-19) 的诊治过程中，抗病毒药物起到了非常重要的作用，但国内外关于抗COVID-19药物引起肝损伤的报道较多，且其导致肝损伤的发生机制尚未明确。本文对COVID-19抗病毒药物的种类及其引起肝损伤机制的相关研究进展作一综述，旨在促进抗病毒药物的合理使用。 |
|---|---|
| AbstractList | 药物性肝损伤是药物使用过程中因药物本身和/或其代谢产物,或由于特殊体质对药物的超敏感性或耐受性降低所导致.在近三年抗击新型冠状病毒感染(COVID-19)的诊治过程中,抗病毒药物起到了非常重要的作用,但国内外关于抗COVID-19药物引起肝损伤的报道较多,且其导致肝损伤的发生机制尚未明确.本文对COVID-19抗病毒药物的种类及其引起肝损伤机制的相关研究进展作一综述,旨在促进抗病毒药物的合理使用. 药物性肝损伤是药物使用过程中因药物本身和/或其代谢产物，或由于特殊体质对药物的超敏感性或耐受性降低所导致。在近三年抗击新型冠状病毒感染 (COVID-19) 的诊治过程中，抗病毒药物起到了非常重要的作用，但国内外关于抗COVID-19药物引起肝损伤的报道较多，且其导致肝损伤的发生机制尚未明确。本文对COVID-19抗病毒药物的种类及其引起肝损伤机制的相关研究进展作一综述，旨在促进抗病毒药物的合理使用。 |
| Abstract_FL | Drug-induced liver injury is caused by the drug itself and/or its metabolites during drug use or occurs due to hypersensitivity or reduced tolerance to the drug in a particular body type.In the last three years of the diagnosis and treatment of coronavirus disease 2019(COVID-19),antiviral drugs have played a very important role,but there are many reports on liver injury caused by anti-COVID-19 drugs in China and globally,with unknown pathogenesis of liver injury caused by such drugs.This article reviews the research advances in the types of antiviral drugs for COVID-19 and their mechanism in inducing liver injury,in order to promote the rational use of antiviral drugs. |
| Author | 曾雪 王红 李福青 李清清 |
| AuthorAffiliation | 遵义医科大学附属医院消化内科, 贵州 遵义 563000 |
| AuthorAffiliation_xml | – name: 遵义医科大学附属医院消化内科, 贵州 遵义 563000 |
| Author_FL | LI Qingqing LI Fuqing WANG Hong ZENG Xue |
| Author_FL_xml | – sequence: 1 fullname: ZENG Xue – sequence: 2 fullname: LI Fuqing – sequence: 3 fullname: LI Qingqing – sequence: 4 fullname: WANG Hong |
| Author_xml | – sequence: 1 fullname: 曾雪 – sequence: 2 fullname: 李福青 – sequence: 3 fullname: 李清清 – sequence: 4 fullname: 王红 |
| BookMark | eNpFkMtKw0AYhQepYKzd-Apu3ETnmuksJVSrFNzoumSSmaKUtDYWoUupopUiXguixoUbV3VjBenjmEkfw0gFF4fDgY_z_5x5kAsboQJgEcEVhCkVq1tuGVOICZwBFoaC24QKngMWghDZDDNnDhSiaE9ChogjKHMsUDL378nzRXL6kvZG6eDEDK9NNzbxjekNpnHSH6bnb8n4bvLxOTl-Mv34e_yaPnSTy6v0NjaPX8nZaAHMaq8eqcKf58HuemnHLduV7Y1Nd61iNxFB3OYSByJQHlYaClyUGtMi4RISzSR0GBU-0VgL5EPkKcQVz5TRAWI-1VpqkgfL094jL9ReWKvuN9qtMLtYrfu1QHY6GP4OAAnP0KUp2mw1DtoqOvxnCSZFnj2EHfIDRhBzXA |
| ContentType | Journal Article |
| Copyright | 2024. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: 2024. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 3V. 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.12449/JCH240230 |
| DatabaseName | ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitle | Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) |
| DatabaseTitleList | Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitle_FL | Pathogenesis of liver injury caused by antiviral drugs for coronavirus disease 2019 |
| EISSN | 2097-3497 |
| EndPage | 407 |
| ExternalDocumentID | lcgdbzz202402037 |
| GroupedDBID | -05 3V. 5XA 5XF 7X7 7XB 88E 8FI 8FJ 8FK 92F 92I ABDBF ABJNI ABUWG ACGFS ACUHS AFKRA ALMA_UNASSIGNED_HOLDINGS AZQEC BENPR CCEZO CCPQU CIEJG CW9 DWQXO EAD EAP EOJEC ESX FYUFA K9. M1P OBODZ OK1 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI RNS TCJ TGQ U1G U5O 2B. 4A8 93N IPNFZ PSX RIG |
| ID | FETCH-LOGICAL-p1317-7b2d9dea2ef0928bf24837b03f5b06549c3f2f91c01ae17e717eea2d15c4ffbf3 |
| IEDL.DBID | 7X7 |
| ISSN | 1001-5256 |
| IngestDate | Thu May 29 04:06:10 EDT 2025 Tue Sep 02 12:18:39 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | 新型冠状病毒 SARS-CoV-2 Chemical and Drug Induced Liver Injury 病理过程 化学性与药物性肝损伤 Pathologic Processes |
| Language | Chinese |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-p1317-7b2d9dea2ef0928bf24837b03f5b06549c3f2f91c01ae17e717eea2d15c4ffbf3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 |
| OpenAccessLink | https://www.proquest.com/docview/3238713126?pq-origsite=%requestingapplication% |
| PQID | 3238713126 |
| PQPubID | 7350069 |
| PageCount | 6 |
| ParticipantIDs | wanfang_journals_lcgdbzz202402037 proquest_journals_3238713126 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-02-01 |
| PublicationDateYYYYMMDD | 2024-02-01 |
| PublicationDate_xml | – month: 02 year: 2024 text: 2024-02-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Changchun |
| PublicationPlace_xml | – name: Changchun |
| PublicationTitle | Linchuang gandanbing zazhi |
| PublicationTitle_FL | Journal of Clinical Hepatology |
| PublicationYear | 2024 |
| Publisher | Journal of Clinical Hepatology 遵义医科大学附属医院消化内科, 贵州 遵义 563000 |
| Publisher_xml | – name: Journal of Clinical Hepatology – name: 遵义医科大学附属医院消化内科, 贵州 遵义 563000 |
| SSID | ssib051369456 ssib061082477 ssj0041983 ssib001103858 ssib053243598 ssib002264326 ssib038074677 |
| Score | 2.3757026 |
| Snippet | 药物性肝损伤是药物使用过程中因药物本身和/或其代谢产物，或由于特殊体质对药物的超敏感性或耐受性降低所导致。在近三年抗击新型冠状病毒感染 (COVID-19)... ... |
| SourceID | wanfang proquest |
| SourceType | Aggregation Database |
| StartPage | 402 |
| Title | 新型冠状病毒感染抗病毒药物引起肝损伤的发生机制 |
| URI | https://www.proquest.com/docview/3238713126 https://d.wanfangdata.com.cn/periodical/lcgdbzz202402037 |
| Volume | 40 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LSyNBEG5WRfEiuz7wkZUIXgenu6fT6ZMYNyEIBhGF3CTTDz1IoquLkKO4iw9k2YcGRM0e9uJJLyqIP8eZyc-wO9Mh8eJhaJpp5lDTXfVVV9VXAEwzzomQHnP0gx2PM-mkJTL9iFOegIIq0iT1WSyk8qveQpEU7YXbjk2rbOnEpqIWFW7uyGewti3aoYIoNbu17ZiuUSa6altodIEeqJGIad1Ai21zCqH7hqvFFI12wBXDte510LkRiFPMa3PLEA02DMFda66RRho16zZjTe9phz1O4NcuOdHYwdKfaovJZhbm8yZwgd030LV3r1RWpfJ6hw3LfQQDFnwm5-Ld8gl8qG4Mgr5FG14fAtnw_C64Pgl-_IuOH6La9_D2d3hQD-t_wuNaPG2c3kZHN8HzWeP-sbF_FZ7WX57_RxcHwc9f0d96ePkUHD4Mg9VcdmU-79g-C86WFih1qI8EE7KEpHIZSvsKGZp5LR9FfFN7yjhWSDHIXViSkErtAUq9WkDCPaV8hUdAd7lSlqMgiSmWmPlIUp8Y8aQlQUpSSgmnwoV8DCRawlizh2Vnrf1rx8CUFVD77SZfF361igwZG3IxHX__ExOg3yyNE6sToHv36zf5WeOGXX-yuTkmQc9c5ksmp8dMtrC0_AoHjNB- |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LTxRBEO7gEsWLUdSAoq4JHidMv6anD8QoLlkeuzEGEm7r9AsOZEHBEPdo0CiGGJ8kRl0PXjzhRUwM8dc4M_sz7N6ZyS4Xbxzm0JmeOlTXdH3V1fUVAONcSqo04Z59sEck116oketHHBAFFTO0S-pTqwfVRTK7RJcGwJ-iFsZdqyz2xO5GrdakOyOfwNa32IAKouDm-gPPdY1y2dWihUaUt1ZQk12KsbywY04_3rIh3MbkzB273jcQmq4sTFW9vMuAt27FMY8JpLjSEdLG5ygUBjmSdeFjQ4WrvOQSG2Q4lD6MNGTaxj_azlaQSmKMMNjKPQEGiTtAKYHB25X63Xs9QAL9I2wxrmy1DzA5tnfSRyhHIQ446bHbUAt3HMVeMbZYJ0TdytHM1xDIw6yEwIc2pKRBTsBqfTafmJ2qutQJ9o-A55NbUdNEzeU-Lzp9FpzJ4W_5Vmav58BAa2UYnKrlCf7zoJJ8-BF_eRk_-5ruHKR7T5P9N8l2O2m_TXb2smFndz998T0-fN_5-avz5HOy2_57-C39uB2_ep2-ayeffsfPDy6AxWNZg4ug1Fxr6hFQxgxrzAXSTFCnnlBTZDRjjEqmfChHwVihjEb-u240esY1Cq7nCuq9XZXLSrRayNHBIR-zS_8XcQ0MVRdq8435mfrcZXDafZZd8x4Dpc2Hj_QVi2I2xdXcVMrg_nFb5z-ASRHP |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E6%96%B0%E5%9E%8B%E5%86%A0%E7%8A%B6%E7%97%85%E6%AF%92%E6%84%9F%E6%9F%93%E6%8A%97%E7%97%85%E6%AF%92%E8%8D%AF%E7%89%A9%E5%BC%95%E8%B5%B7%E8%82%9D%E6%8D%9F%E4%BC%A4%E7%9A%84%E5%8F%91%E7%94%9F%E6%9C%BA%E5%88%B6&rft.jtitle=Linchuang+gandanbing+zazhi&rft.au=%E6%9B%BE%E9%9B%AA&rft.au=%E6%9D%8E%E7%A6%8F%E9%9D%92&rft.au=%E6%9D%8E%E6%B8%85%E6%B8%85&rft.au=%E7%8E%8B%E7%BA%A2&rft.date=2024-02-01&rft.pub=Journal+of+Clinical+Hepatology&rft.issn=1001-5256&rft.eissn=2097-3497&rft.volume=40&rft.issue=2&rft.spage=402&rft_id=info:doi/10.12449%2FJCH240230 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Flcgdbzz%2Flcgdbzz.jpg |