肝再生在对乙酰氨基酚诱导的肝损伤修复中的作用
肝再生在对乙酰氨基酚 (APAP) 诱导的肝损伤后恢复中有着至关重要的作用。APAP过量服用后，通常是肝损伤程度越大，再生的程度就越大，从而导致肝损伤的消退和大多数情况下的自发恢复。然而，严重APAP过量会导致肝再生受损和无法控制的肝损伤，导致无法恢复，甚至死亡。在APAP肝损伤后，肝脏中细胞之间的相互作用对再生反应非常重要。肝再生由多种增殖信号通路共同调控，这些通路涉及激酶、核受体、转录因子、转录共激活因子。严重的APAP过量后会抑制增殖信号通路的激活，导致细胞周期停滞和肝再生受损。虽然肝再生在APAP肝损伤后的修复过程中发挥关键作用，但目前其发挥作用的潜在机制尚不明确。本文就已有的相关研究...
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| Published in | Linchuang gandanbing zazhi Vol. 40; no. 9; pp. 1902 - 1907 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.09.2024
首都医科大学附属北京佑安医院,北京肝病研究所,北京 100069 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.12449/JCH240929 |
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| Abstract | 肝再生在对乙酰氨基酚 (APAP) 诱导的肝损伤后恢复中有着至关重要的作用。APAP过量服用后，通常是肝损伤程度越大，再生的程度就越大，从而导致肝损伤的消退和大多数情况下的自发恢复。然而，严重APAP过量会导致肝再生受损和无法控制的肝损伤，导致无法恢复，甚至死亡。在APAP肝损伤后，肝脏中细胞之间的相互作用对再生反应非常重要。肝再生由多种增殖信号通路共同调控，这些通路涉及激酶、核受体、转录因子、转录共激活因子。严重的APAP过量后会抑制增殖信号通路的激活，导致细胞周期停滞和肝再生受损。虽然肝再生在APAP肝损伤后的修复过程中发挥关键作用，但目前其发挥作用的潜在机制尚不明确。本文就已有的相关研究对肝再生在APAP诱导的肝损伤中的作用进行综述， 为进一步的基础研究提供参考。 |
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| AbstractList | 肝再生在对乙酰氨基酚(APAP)诱导的肝损伤后恢复中有着至关重要的作用.APAP过量服用后,通常是肝损伤程度越大,再生的程度就越大,从而导致肝损伤的消退和大多数情况下的自发恢复.然而,严重APAP过量会导致肝再生受损和无法控制的肝损伤,导致无法恢复,甚至死亡.在APAP肝损伤后,肝脏中细胞之间的相互作用对再生反应非常重要.肝再生由多种增殖信号通路共同调控,这些通路涉及激酶、核受体、转录因子、转录共激活因子.严重的APAP过量后会抑制增殖信号通路的激活,导致细胞周期停滞和肝再生受损.虽然肝再生在APAP肝损伤后的修复过程中发挥关键作用,但目前其发挥作用的潜在机制尚不明确.本文就已有的相关研究对肝再生在APAP诱导的肝损伤中的作用进行综述,为进一步的基础研究提供参考. 肝再生在对乙酰氨基酚 (APAP) 诱导的肝损伤后恢复中有着至关重要的作用。APAP过量服用后，通常是肝损伤程度越大，再生的程度就越大，从而导致肝损伤的消退和大多数情况下的自发恢复。然而，严重APAP过量会导致肝再生受损和无法控制的肝损伤，导致无法恢复，甚至死亡。在APAP肝损伤后，肝脏中细胞之间的相互作用对再生反应非常重要。肝再生由多种增殖信号通路共同调控，这些通路涉及激酶、核受体、转录因子、转录共激活因子。严重的APAP过量后会抑制增殖信号通路的激活，导致细胞周期停滞和肝再生受损。虽然肝再生在APAP肝损伤后的修复过程中发挥关键作用，但目前其发挥作用的潜在机制尚不明确。本文就已有的相关研究对肝再生在APAP诱导的肝损伤中的作用进行综述， 为进一步的基础研究提供参考。 |
| Abstract_FL | Liver regeneration plays a crucial role in the recovery after liver injury induced by N-acetyl-p-aminophenol(APAP).After APAP overdose,the degree of regeneration increases with the extent of liver injury,leading to the resolution of liver injury and spontaneous recovery in most cases.However,severe APAP overdose can impair liver regeneration and result in uncontrolled liver injury,even failure to recover or death in severe cases.Following APAP-induced liver injury,interactions between cells in the liver are essential for regenerative response.Liver regeneration is jointly regulated by multiple proliferative signaling pathways,involving various kinases,nuclear receptors,transcription factors,and coactivators.Severe APAP overdose can inhibit the activation of proliferative signaling pathways,thereby causing cell cycle arrest and impairing liver regeneration.Although liver regeneration plays a critical role in the repair of APAP-induced liver injury,the underlying mechanisms remain unclear.This article reviews the research advances in the role of liver regeneration in APAP-induced liver injury,in order to provide a reference for further basic research in this area. |
| Author | 莫胤康 范子豪 任锋 |
| AuthorAffiliation | 首都医科大学附属北京佑安医院,北京肝病研究所,北京 100069 |
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| Author_FL | REN Feng MO Yinkang FAN Zihao |
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| Keywords | Signal Transduction 修复 Acetaminophen 信号传导 Chemical and Drug Induced Liver Injury 对乙酰氨基酚 Repair 化学性与药物性肝损伤 |
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| Snippet | 肝再生在对乙酰氨基酚 (APAP) 诱导的肝损伤后恢复中有着至关重要的作用。APAP过量服用后，通常是肝损伤程度越大，再生的程度就越大，从而导致肝损伤的消退和大多数情况下的... 肝再生在对乙酰氨基酚(APAP)诱导的肝损伤后恢复中有着至关重要的作用.APAP过量服用后,通常是肝损伤程度越大,再生的程度就越大,从而导致肝损伤的消退和大多数情况下的自发... |
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| Title | 肝再生在对乙酰氨基酚诱导的肝损伤修复中的作用 |
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