陕西地区孕妇HBV感染现状与母婴传播的危险因素
目的调查陕西省孕妇HBV感染率并筛选母婴传播高危人群。方法自2010年-2015年连续调查了陕西省18家医院13 451名孕妇HBV感染情况,对所有HBs Ag阳性孕妇所生婴儿进行联合免疫,采用单因素及多因素logistic回归分析母婴传播的高危因素。计量资料组间比较采用t检验或Mann-Whitney U检验。计数资料多组间比较采用χ2检验。结果陕西省孕妇HBsAg流行率为7. 07%,陕南地区高达9. 40%。HBV母婴传播率为5. 21%,单因素分析显示母亲HBsAg滴度、HBeAg滴度、HBeAg阳性及HBV DNA载量与婴儿HBV感染相关,多因素分析显示母亲HBV DNA载量是母婴传...
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| Published in | Linchuang gandanbing zazhi Vol. 35; no. 7; pp. 1489 - 1492 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.07.2019
西安交通大学第二附属医院小儿外科,西安,710000%西安交通大学第一附属医院感染科,西安,710061 |
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| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2019.07.013 |
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| Abstract | 目的调查陕西省孕妇HBV感染率并筛选母婴传播高危人群。方法自2010年-2015年连续调查了陕西省18家医院13 451名孕妇HBV感染情况,对所有HBs Ag阳性孕妇所生婴儿进行联合免疫,采用单因素及多因素logistic回归分析母婴传播的高危因素。计量资料组间比较采用t检验或Mann-Whitney U检验。计数资料多组间比较采用χ2检验。结果陕西省孕妇HBsAg流行率为7. 07%,陕南地区高达9. 40%。HBV母婴传播率为5. 21%,单因素分析显示母亲HBsAg滴度、HBeAg滴度、HBeAg阳性及HBV DNA载量与婴儿HBV感染相关,多因素分析显示母亲HBV DNA载量是母婴传播的独立危险因素 (相对危险度:1. 586,95%可信区间:1. 020～2. 465,P=0. 041) 。发生母婴传播的HBV感染孕妇中,84. 62%为HBeAg阳性且HBV DNA> 106IU/ml;发生母婴传播的婴儿15. 38%来自于HBeAg阴性的HBV感染孕妇。HBeAg阳性且HBV DNA> 106IU/ml的孕妇中,婴儿发生母婴传播的相对危险度... |
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| AbstractList | 目的调查陕西省孕妇HBV感染率并筛选母婴传播高危人群。方法自2010年-2015年连续调查了陕西省18家医院13 451名孕妇HBV感染情况,对所有HBs Ag阳性孕妇所生婴儿进行联合免疫,采用单因素及多因素logistic回归分析母婴传播的高危因素。计量资料组间比较采用t检验或Mann-Whitney U检验。计数资料多组间比较采用χ2检验。结果陕西省孕妇HBsAg流行率为7. 07%,陕南地区高达9. 40%。HBV母婴传播率为5. 21%,单因素分析显示母亲HBsAg滴度、HBeAg滴度、HBeAg阳性及HBV DNA载量与婴儿HBV感染相关,多因素分析显示母亲HBV DNA载量是母婴传播的独立危险因素 (相对危险度:1. 586,95%可信区间:1. 020～2. 465,P=0. 041) 。发生母婴传播的HBV感染孕妇中,84. 62%为HBeAg阳性且HBV DNA> 106IU/ml;发生母婴传播的婴儿15. 38%来自于HBeAg阴性的HBV感染孕妇。HBeAg阳性且HBV DNA> 106IU/ml的孕妇中,婴儿发生母婴传播的相对危险度... R512.62%R714; 目的 调查陕西省孕妇HBV感染率并筛选母婴传播高危人群.方法 自2010年-2015年连续调查了陕西省18家医院13451名孕妇HBV感染情况,对所有HBsAg阳性孕妇所生婴儿进行联合免疫,采用单因素及多因素logistic回归分析母婴传播的高危因素.计量资料组间比较采用t检验或Mann-Whitney U检验.计数资料多组间比较采用χ2检验.结果 陕西省孕妇HBsAg流行率为7.07％,陕南地区高达9.40％.HBV母婴传播率为5.21％,单因素分析显示母亲HBsAg滴度、HBeAg滴度、HBeAg阳性及HBV DNA载量与婴儿HBV感染相关,多因素分析显示母亲HBV DNA载量是母婴传播的独立危险因素(相对危险度:1.586,95％可信区间:1.020～2.465,P=0.041).发生母婴传播的HBV感染孕妇中,84.62％为HBeAg阳性且HBV DNA>106 IU/ml;发生母婴传播的婴儿15.38％来自于HBeAg阴性的HBV感染孕妇.HBeAg阳性且HBV DNA>106 IU/ml的孕妇中,婴儿发生母婴传播的相对危险度为1.210(1.129～1.297);而HBeAg阴性,但HBV DNA>2×103 IU/ml且HBsAg>104 IU/ml的孕妇中,婴儿发生母婴传播的相对危险度为26.062(2.633～258.024).结论 陕西省孕妇HBV感染率仍高,HBeAg阳性且高病毒载量孕妇发生母婴传播风险较高;HBeAg阴性母亲所生婴儿HBV感染率虽然低,但当母亲HBV DNA>2×103 IU/ml且HBsAg>104 IU/ml时仍有较高母婴传播的风险. |
| Author | 王静 何英利 赵英仁 朱娅鸽 余强 刘锦锋 闫涛涛 代晓敏 陈天艳 冯亚丽 |
| AuthorAffiliation | 西安交通大学第二附属医院小儿外科,西安,710000%西安交通大学第一附属医院感染科,西安,710061 |
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| Snippet | 目的调查陕西省孕妇HBV感染率并筛选母婴传播高危人群。方法自2010年-2015年连续调查了陕西省18家医院13 451名孕妇HBV感染情况,对所有HBs Ag阳性孕妇所生婴儿进行联合免疫,... R512.62%R714; 目的 调查陕西省孕妇HBV感染率并筛选母婴传播高危人群.方法 自2010年-2015年连续调查了陕西省18家医院13451名孕妇HBV感染情况,对所有HBsAg阳性孕妇所生婴儿... |
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| Title | 陕西地区孕妇HBV感染现状与母婴传播的危险因素 |
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