抑制性受体TIGIT与慢性HBV感染中免疫紊乱的关系
持续HBV感染改变了天然免疫细胞和获得性免疫细胞表面受体的表达，由此引发的多种免疫紊乱，可导致免疫逃逸，最终使疾病慢性化。研究表明，抑制性受体的上调是患者免疫紊乱的主要原因，阻断抑制性受体可一定程度上恢复患者的免疫功能。T淋巴细胞免疫球蛋白和免疫受体酪氨酸抑制性基序结构域(TIGIT)是目前较为关注的一种新型抑制性受体，在NK细胞和T淋巴细胞中高水平表达。研究发现，TIGIT在慢性病毒感染中发挥重要作用，现就TIGIT与慢性HBV感染中免疫紊乱的相关性研究进展进行简要综述。...
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| Published in | Linchuang gandanbing zazhi Vol. 39; no. 6; pp. 1418 - 1423 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.06.2023
甘肃中医药大学第一临床医学院,兰州 730030%甘肃中医药大学第一临床医学院,兰州 730030 中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050%兰州大学第二医院消化内科,兰州 730030%中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2023.06.026 |
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| Abstract | 持续HBV感染改变了天然免疫细胞和获得性免疫细胞表面受体的表达，由此引发的多种免疫紊乱，可导致免疫逃逸，最终使疾病慢性化。研究表明，抑制性受体的上调是患者免疫紊乱的主要原因，阻断抑制性受体可一定程度上恢复患者的免疫功能。T淋巴细胞免疫球蛋白和免疫受体酪氨酸抑制性基序结构域(TIGIT)是目前较为关注的一种新型抑制性受体，在NK细胞和T淋巴细胞中高水平表达。研究发现，TIGIT在慢性病毒感染中发挥重要作用，现就TIGIT与慢性HBV感染中免疫紊乱的相关性研究进展进行简要综述。 |
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| AbstractList | 持续HBV感染改变了天然免疫细胞和获得性免疫细胞表面受体的表达,由此引发的多种免疫紊乱,可导致免疫逃逸,最终使疾病慢性化.研究表明,抑制性受体的上调是患者免疫紊乱的主要原因,阻断抑制性受体可一定程度上恢复患者的免疫功能.T淋巴细胞免疫球蛋白和免疫受体酪氨酸抑制性基序结构域(TIGIT)是目前较为关注的一种新型抑制性受体,在NK细胞和T淋巴细胞中高水平表达.研究发现,TIGIT在慢性病毒感染中发挥重要作用,现就TIGIT与慢性HBV感染中免疫紊乱的相关性研究进展进行简要综述. 持续HBV感染改变了天然免疫细胞和获得性免疫细胞表面受体的表达，由此引发的多种免疫紊乱，可导致免疫逃逸，最终使疾病慢性化。研究表明，抑制性受体的上调是患者免疫紊乱的主要原因，阻断抑制性受体可一定程度上恢复患者的免疫功能。T淋巴细胞免疫球蛋白和免疫受体酪氨酸抑制性基序结构域(TIGIT)是目前较为关注的一种新型抑制性受体，在NK细胞和T淋巴细胞中高水平表达。研究发现，TIGIT在慢性病毒感染中发挥重要作用，现就TIGIT与慢性HBV感染中免疫紊乱的相关性研究进展进行简要综述。 |
| Author | 姚晓文 王蓉 周玉霞 于晓辉 王彩红 张久聪 郑晓凤 |
| AuthorAffiliation | 甘肃中医药大学第一临床医学院,兰州 730030%甘肃中医药大学第一临床医学院,兰州 730030;中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050%兰州大学第二医院消化内科,兰州 730030%中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050 |
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| Author_FL | YAO Xiaowen ZHENG Xiaofeng WANG Rong ZHANG Jiucong YU Xiaohui ZHOU Yuxia WANG Caihong |
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| Keywords | 受体,免疫 免疫紊乱 乙型肝炎病毒 |
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| Snippet | 持续HBV感染改变了天然免疫细胞和获得性免疫细胞表面受体的表达，由此引发的多种免疫紊乱，可导致免疫逃逸，最终使疾病慢性化。研究表明，抑制性受体的上调是患者免疫紊乱... 持续HBV感染改变了天然免疫细胞和获得性免疫细胞表面受体的表达,由此引发的多种免疫紊乱,可导致免疫逃逸,最终使疾病慢性化.研究表明,抑制性受体的上调是患者免疫紊乱的主... |
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